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Nicoló Tonali
Nicoló Tonali
Researcher in CEA Saclay
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Year
The positive side of the Alzheimer’s disease amyloid cross-interactions: the case of the Aβ 1-42 peptide with tau, TTR, CysC, and ApoA1
L Ciccone, C Shi, D Di Lorenzo, AC Van Baelen, N Tonali
Molecules 25 (10), 2439, 2020
622020
β-Hairpin mimics containing a piperidine–pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species
S Pellegrino, N Tonali, E Erba, J Kaffy, M Taverna, A Contini, M Taylor, ...
Chemical science 8 (2), 1295-1302, 2017
512017
Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: Analysis of structural data for future drug design
L Ciccone, N Tonali, S Nencetti, E Orlandini
Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 1145-1162, 2020
452020
Designed glycopeptidomimetics disrupt protein–Protein interactions mediating amyloid β-peptide aggregation and restore neuroblastoma cell viability
J Kaffy, D Brinet, JL Soulier, I Correia, N Tonali, KF Fera, Y Iacone, ...
Journal of Medicinal Chemistry 59 (5), 2025-2040, 2016
402016
Real‐Time BODIPY‐Binding Assay To Screen Inhibitors of the Early Oligomerization Process of Aβ1–42 Peptide
N Tonali, VI Dodero, J Kaffy, L Hericks, S Ongeri, N Sewald
ChemBioChem 21 (8), 1129-1135, 2020
222020
Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation
N Tonali, J Kaffy, JL Soulier, ML Gelmi, E Erba, M Taverna, ...
European Journal of Medicinal Chemistry 154, 280-293, 2018
212018
Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides
N Tonali, I Correia, J Lesma, G Bernadat, S Ongeri, O Lequin
Organic & Biomolecular Chemistry 18 (18), 3452-3458, 2020
152020
Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a
M Salinas, P Kessler, D Douguet, D Sarraf, N Tonali, R Thai, D Servent, ...
Neuropharmacology 185, 108453, 2021
142021
Application of PROTAC strategy to TTR-Aβ protein-protein interaction for the development of Alzheimer’s disease drugs
N Tonali, S Nencetti, E Orlandini, L Ciccone
Neural Regeneration Research 16 (8), 1554-1555, 2021
132021
Pepsin Digest of Gliadin Forms Spontaneously Amyloid‐Like Nanostructures Influencing the Expression of Selected Pro‐Inflammatory, Chemoattractant, and Apoptotic Genes in Caco‐2 …
MG Herrera, F Nicoletti, M Gras, PW Dörfler, N Tonali, Y Hannappel, ...
Molecular nutrition & food research 65 (16), 2100200, 2021
132021
Physiological metals can induce conformational changes in transthyretin structure: neuroprotection or misfolding induction?
L Ciccone, N Tonali, W Shepard, S Nencetti, E Orlandini
Crystals 11 (4), 354, 2021
112021
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis
L Ciccone, S Nencetti, N Tonali, C Fruchart-Gaillard, W Shepard, E Nuti, ...
Bioorganic & Medicinal Chemistry 28 (18), 115673, 2020
112020
Phenothiazine‐Biaryl‐Containing Fluorescent RGD Peptides
E Ghabraie, I Kemker, N Tonali, M Ismail, VI Dodero, N Sewald
Chemistry–A European Journal 26 (52), 12036-12042, 2020
102020
Implementing complementary approaches to shape the mechanism of α-synuclein oligomerization as a model of amyloid aggregation
M Giampà, MJ Amundarain, MG Herrera, N Tonali, VI Dodero
Molecules 27 (1), 88, 2021
82021
Towards a general synthesis of di-aza-amino acids containing peptides
F Bizet, N Tonali, JL Soulier, A Oliva, J Kaffy, B Crousse, S Ongeri
New Journal of Chemistry 42 (20), 17062-17072, 2018
82018
Insights into the structural conformations of the tau protein in different aggregation status
L Pinzi, N Bisi, C Sorbi, S Franchini, N Tonali, G Rastelli
Molecules 28 (11), 4544, 2023
72023
Proteolytically Stable Diaza-Peptide Foldamers Mimic Helical Hot Spots of Protein–Protein Interactions and Act as Natural Chaperones
C Shi, J Kaffy, T Ha-Duong, JF Gallard, A Pruvost, A Mabondzo, ...
Journal of Medicinal Chemistry 66 (17), 12005-12017, 2023
62023
Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization
L Ciccone, N Tonali, C Fruchart-Gaillard, L Barlettani, A Rossello, A Braca, ...
Crystals 12 (5), 638, 2022
62022
β-Hairpin peptide mimics decrease human islet amyloid polypeptide (hIAPP) aggregation
J Lesma, F Bizet, C Berardet, N Tonali, S Pellegrino, M Taverna, ...
Frontiers in Cell and Developmental Biology 9, 729001, 2021
62021
Peptidotriazolamers Inhibit Aβ (1–42) Oligomerization and Cross a Blood‐Brain‐Barrier Model
N Tonali, L Hericks, DC Schröder, O Kracker, R Krzemieniecki, J Kaffy, ...
ChemPlusChem 86 (6), 840-851, 2021
52021
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