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James Chen
James Chen
Director of Computational Biology, TrexBio
Verified email at trex.bio
Title
Cited by
Cited by
Year
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
CA Higgins, JC Chen, JE Cerise, CAB Jahoda, AM Christiano
Proceedings of the National Academy of Sciences 110 (49), 19679-19688, 2013
3562013
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata
MK Crispin, JM Ko, BG Craiglow, S Li, G Shankar, JR Urban, JC Chen, ...
JCI insight 1 (15), 2016
3442016
Tissue engineering of human hair follicles using a biomimetic developmental approach
HE Abaci, A Coffman, Y Doucet, J Chen, J Jacków, E Wang, Z Guo, ...
Nature communications 9 (1), 5301, 2018
2272018
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
S Harel, CA Higgins, JE Cerise, Z Dai, JC Chen, R Clynes, AM Christiano
Science Advances 1 (9), e1500973, 2015
2152015
Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks
JC Chen, MJ Alvarez, F Talos, H Dhruv, GE Rieckhof, A Iyer, KL Diefes, ...
Cell 159 (2), 402-414, 2014
2052014
An open-label pilot study to evaluate the efficacy of tofacitinib in moderate to severe patch-type alopecia areata, totalis, and universalis
A Jabbari, F Sansaricq, J Cerise, JC Chen, A Bitterman, G Ulerio, ...
Journal of investigative dermatology 138 (7), 1539-1545, 2018
1742018
Molecular signatures define alopecia areata subtypes and transcriptional biomarkers
A Jabbari, JE Cerise, JC Chen, J Mackay-Wiggan, M Duvic, V Price, ...
EBioMedicine 7, 240-247, 2016
1022016
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata
Z Dai, J Chen, Y Chang, AM Christiano
JCI insight 6 (7), 2021
512021
The tissue factor pathway and wound healing
M Hoffman
Seminars in thrombosis and hemostasis 44 (02), 142-150, 2018
412018
IKZF1 enhances immune infiltrate recruitment in solid tumors and susceptibility to immunotherapy
JC Chen, R Perez-Lorenzo, YM Saenger, CG Drake, AM Christiano
Cell Systems 7 (1), 92-103. e4, 2018
342018
Master Regulators of Infiltrate Recruitment in Autoimmune Disease Identified through Network-Based Molecular Deconvolution
JC Chen, JE Cerise, A Jabbari, R Clynes, AM Christiano
Cell Systems 1 (5), 326-337, 2015
272015
DIGGIT: a Bioconductor package to infer genetic variants driving cellular phenotypes
MJ Alvarez, JC Chen, A Califano
Bioinformatics 31 (24), 4032-4034, 2015
142015
An open-label study evaluating the efficacy of abatacept in alopecia areata
J Mackay-Wiggan, BN Sallee, EHC Wang, F Sansaricq, N Nguyen, C Kim, ...
Journal of the American Academy of Dermatology 84 (3), 841-844, 2021
132021
Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways
EHC Wang, I Monga, BN Sallee, JC Chen, AR Abdelaziz, ...
PNAS nexus 1 (3), pgac111, 2022
102022
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Sci Adv. 2015; 1 (9): e1500973
S Harel, CA Higgins, JE Cerise, Z Dai, JC Chen, R Clynes, AM Christiano
7
Regulatory network analysis defines unique drug mechanisms of action and facilitates patient-drug matching in alopecia areata clinical trials
JC Chen, Z Dai, AM Christiano
Computational and Structural Biotechnology Journal 19, 4751-4758, 2021
62021
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight. 2016; 1 (15): e89776
M Kennedy Crispin, JM Ko, BG Craiglow, S Li, G Shankar, JR Urban, ...
5
331 an open label clinical trial of the JAK inhibitor tofacitinib for alopecia areata
A Jabbari, J Cerise, JC Chen, F Sansaricq, R Clynes, AM Christiano, ...
Journal of Investigative Dermatology 137 (5), S56, 2017
32017
277 An open label pilot clinical trial of the JAK inhibitor tofacitinib for alopecia areata
A Jabbari, J Cerise, JC Chen, G Ulerio, J Borbon, S Sidharthan, R Clynes, ...
Journal of Investigative Dermatology 136 (5), S49, 2016
32016
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Sci Adv 1 (9)
S Harel, CA Higgins, JE Cerise, Z Dai, JC Chen, R Clynes, AM Christiano
32015
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Articles 1–20