NNMT silencing activates tumor suppressor PP2A, inactivates oncogenic STKs, and inhibits tumor forming ability K Palanichamy, S Kanji, N Gordon, K Thirumoorthy, JR Jacob, ... Clinical Cancer Research 23 (9), 2325-2334, 2017 | 75 | 2017 |
Methionine and kynurenine activate oncogenic kinases in glioblastoma, and methionine deprivation compromises proliferation K Palanichamy, K Thirumoorthy, S Kanji, N Gordon, R Singh, JR Jacob, ... Clinical Cancer Research 22 (14), 3513-3523, 2016 | 61 | 2016 |
Altered gemcitabine and nab-paclitaxel scheduling improves therapeutic efficacy compared with standard concurrent treatment in preclinical models of pancreatic cancer AR Wolfe, R Robb, A Hegazi, L Abushahin, L Yang, DL Shyu, JG Trevino, ... Clinical Cancer Research 27 (2), 554-565, 2021 | 10 | 2021 |
Lack of constitutively active DNA repair sensitizes glioblastomas to Akt inhibition and induces synthetic lethality with radiation treatment in a p53-dependent manner K Palanichamy, D Patel, JR Jacob, KT Litzenberg, N Gordon, K Acus, ... Molecular cancer therapeutics 17 (2), 336-346, 2018 | 10 | 2018 |
Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticity K Palanichamy, JR Jacob, KT Litzenberg, A Ray-Chaudhury, ... EBioMedicine 36, 281-292, 2018 | 8 | 2018 |
Clinically relevant brain tumor model and device development for experimental therapeutics K Palanichamy, K Acus, JR Jacob, A Chakravarti Journal of Analytical Oncology 4 (1), 5-12, 2015 | 5 | 2015 |
Nicotinamide N-methyltransferase epigenetic and metabolic rewiring promotes metastatic progression JR Jacob, A Chakravarti, K Palanichamy Biotarget 3, 2019 | 1 | 2019 |
Mir-194-3p suppresses tumorigenic potential of glioblastoma stem cells by targeting the canonical NF-kB pathway R Singh, K Palanichamy, JR Jacob, A Chakravarti Cancer Research 76 (14_Supplement), 1113-1113, 2016 | 1 | 2016 |
miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition JR Jacob, R Singh, M Okamoto, A Chakravarti, K Palanichamy Iscience 27 (1), 2024 | | 2024 |
Elucidating the Molecular Mechanisms Exploited by Glioblastoma to Evade the Tumor Suppressive Functions of Protein Phosphatase 2A JR Jacob The Ohio State University, 2023 | | 2023 |
Nicotinamide N-methyltransferase inhibits Protein Phosphatase 2A activity by promoting Y307 phosphorylation JR Jacob, A Chakravarti, K Palanichamy Cancer Research 77 (13_Supplement), 2383-2383, 2017 | | 2017 |