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Xun Bao
Xun Bao
Research Scientist, Karmanos Cancer Institute, Wayne State University
Verified email at mclaren.org
Title
Cited by
Cited by
Year
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
PL Sulkowski, S Oeck, J Dow, NG Economos, L Mirfakhraie, Y Liu, ...
Nature 582 (7813), 586-591, 2020
2712020
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
PL Sulkowski, RK Sundaram, S Oeck, CD Corso, Y Liu, S Noorbakhsh, ...
Nature genetics 50 (8), 1086-1092, 2018
2132018
Protein expression and functional relevance of efflux and uptake drug transporters at the blood–brain barrier of human brain and glioblastoma
X Bao, J Wu, Y Xie, S Kim, S Michelhaugh, J Jiang, S Mittal, N Sanai, J Li
Clinical Pharmacology & Therapeutics 107 (5), 1116-1127, 2020
662020
A phase 0 trial of ribociclib in recurrent glioblastoma patients incorporating a tumor pharmacodynamic-and pharmacokinetic-guided expansion cohort
AC Tien, J Li, X Bao, A Derogatis, S Kim, S Mehta, N Sanai
Clinical Cancer Research 25 (19), 5777-5786, 2019
642019
Pharmacometabolomics reveals irinotecan mechanism of action in cancer patients
X Bao, J Wu, S Kim, P LoRusso, J Li
The Journal of Clinical Pharmacology 59 (1), 20-34, 2019
622019
Quantitative and mechanistic understanding of AZD1775 penetration across human blood–brain barrier in glioblastoma patients using an IVIVE–PBPK modeling approach
J Li, J Wu, X Bao, N Honea, Y Xie, S Kim, A Sparreboom, N Sanai
Clinical Cancer Research 23 (24), 7454-7466, 2017
612017
Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation …
B Haynes, Y Zhang, F Liu, J Li, S Petit, H Kothayer, X Bao, AD Westwell, ...
Nanomedicine: Nanotechnology, Biology and Medicine 12 (3), 745-757, 2016
522016
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy
AS Dekhne, K Shah, GS Ducker, JM Katinas, J Wong-Roushar, ...
Molecular cancer therapeutics 18 (10), 1787-1799, 2019
512019
Amino acid-linked platinum (II) analogues have altered specificity for RNA compared to cisplatin
K Rijal, X Bao, CS Chow
Chemical Communications 50 (30), 3918-3920, 2014
392014
Evaluation of hybrid theoretical approaches for structural determination of a glycine-linked cisplatin derivative via infrared multiple photon dissociation (IRMPD) action …
CC He, B Kimutai, X Bao, L Hamlow, Y Zhu, SF Strobehn, J Gao, ...
The Journal of Physical Chemistry A 119 (44), 10980-10987, 2015
382015
Physiologically based pharmacokinetic modeling of central nervous system pharmacokinetics of CDK4/6 inhibitors to guide selection of drug and dosing regimen for brain cancer …
J Li, J Jiang, J Wu, X Bao, N Sanai
Clinical Pharmacology & Therapeutics 109 (2), 494-506, 2021
302021
Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry
X Bao, J Wu, N Sanai, J Li
Journal of pharmaceutical and biomedical analysis 166, 197-204, 2019
292019
A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor
X Bao, J Wu, N Sanai, J Li
Journal of pharmaceutical analysis 8 (1), 20-26, 2018
222018
Nano-delivery of RAD6/Translesion Synthesis Inhibitor SMI#9 for Triple-negative Breast Cancer Therapy
N Saadat, F Liu, B Haynes, P Nangia-Makker, X Bao, J Li, LA Polin, ...
Molecular cancer therapeutics 17 (12), 2586-2597, 2018
192018
Strategy for tumor-selective disruption of androgen receptor function in the spectrum of prostate cancer
R Rosati, L Polin, C Ducker, J Li, X Bao, D Selvakumar, S Kim, B Xhabija, ...
Clinical Cancer Research 24 (24), 6509-6522, 2018
182018
Mechanistic modeling of central nervous system pharmacokinetics and target engagement of HER2 tyrosine kinase inhibitors to inform treatment of breast cancer brain metastases
J Li, J Jiang, X Bao, V Kumar, SC Alley, S Peterson, AJ Lee
Clinical Cancer Research 28 (15), 3329-3341, 2022
172022
Discovery of 6-substituted thieno [2, 3-d] pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide …
A Wallace-Povirk, N Tong, J Wong-Roushar, C O'Connor, X Zhou, Z Hou, ...
Bioorganic & medicinal chemistry 37, 116093, 2021
172021
A phase 0 trial of ceritinib in patients with brain metastases and recurrent glioblastoma
S Mehta, R Fiorelli, X Bao, C Pennington-Krygier, A Derogatis, S Kim, ...
Clinical Cancer Research 28 (2), 289-297, 2022
152022
Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia
KH Hurrish, X Qiao, X Li, Y Su, J Carter, J Ma, HA Kalpage, M Hüttemann, ...
Biochemical pharmacology 205, 115283, 2022
142022
Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer
X Bao, J Wu, J Jiang, AC Tien, N Sanai, J Li
Clinical and translational science 14 (4), 1265-1271, 2021
142021
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