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Rachelle Gent
Rachelle Gent
Verified email at sun.ac.za
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The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione …
R Gent, T du Toit, LM Bloem, AC Swart
The Journal of steroid biochemistry and molecular biology 189, 116-126, 2019
362019
Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone
L Barnard, R Gent, D Van Rooyen, AC Swart
The Journal of Steroid Biochemistry and Molecular Biology 174, 86-95, 2017
342017
The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway
D van Rooyen, R Gent, L Barnard, AC Swart
The Journal of Steroid Biochemistry and Molecular Biology 178, 203-212, 2018
312018
11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17, 20-lyase to produce …
R Gent, T du Toit, AC Swart
The Journal of Steroid Biochemistry and Molecular Biology 191, 105369, 2019
92019
Non-invasive assessment of fecal glucocorticoid, progesterone, and androgen metabolites and microbiome in free-ranging southern white rhinoceros (Ceratotherium simum simum) in …
KH Kothmann, A Jons, B Wilhelmi, N Kasozi, L Graham, R Gent, SL Atkin, ...
General and Comparative Endocrinology 329, 114099, 2022
62022
Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros (Ceratotherium simum simum …
R Gent, ID Barbier, SL Atkin, AE Newell-Fugate, AC Swart
Journal of Chromatography B 1215, 123576, 2023
42023
Androstenedione is the preferred substrate for cytochrome P450 11β-hydroxylase leading to the production of 11β-hydroxyandrostenedione in the adrenal gland
ID Barbier, R Gent, T Du Toit, AC Swart
Journal of the Endocrine Society 5 (Suppl 1), A65, 2021
42021
C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors
R Gent, D Van Rooyen, SL Atkin, AC Swart
International Journal of Molecular Sciences 25 (1), 101, 2023
12023
The metabolism and receptor interactions of C11-oxy steroids: Implications for hormonal homeostasis and pathophysiology
R Gent
Stellenbosch University, 2024
2024
CYP11B and CYP17A1 in the Biosynthesis and Metabolism of C11‐oxy Steroids
AC Swart, D van Rooyen, R Gent, T du Toit
The FASEB Journal 34 (S1), 1-1, 2020
2020
SAT-344 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrgenase Inhibitor, Is Metabolised In Vitro by Adrenal Steroidogenic Enzymes
R Gent, A Swart
Journal of the Endocrine Society 3 (Supplement_1), SAT-344, 2019
2019
11α-Hydroxyprogesterone, a potent 11ß-hydroxysteroid
R Gent, T du Toit, AC Swart
2019
Adrenal C11-oxy C21 steroids contribute to the C11-oxy
L Barnard, R Gent, D van Rooyen
Endocr. Rev 21, 245-291, 2000
2000
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