The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione … R Gent, T du Toit, LM Bloem, AC Swart The Journal of steroid biochemistry and molecular biology 189, 116-126, 2019 | 36 | 2019 |
Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone L Barnard, R Gent, D Van Rooyen, AC Swart The Journal of Steroid Biochemistry and Molecular Biology 174, 86-95, 2017 | 34 | 2017 |
The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway D van Rooyen, R Gent, L Barnard, AC Swart The Journal of Steroid Biochemistry and Molecular Biology 178, 203-212, 2018 | 31 | 2018 |
11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17, 20-lyase to produce … R Gent, T du Toit, AC Swart The Journal of Steroid Biochemistry and Molecular Biology 191, 105369, 2019 | 9 | 2019 |
Non-invasive assessment of fecal glucocorticoid, progesterone, and androgen metabolites and microbiome in free-ranging southern white rhinoceros (Ceratotherium simum simum) in … KH Kothmann, A Jons, B Wilhelmi, N Kasozi, L Graham, R Gent, SL Atkin, ... General and Comparative Endocrinology 329, 114099, 2022 | 6 | 2022 |
Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros (Ceratotherium simum simum … R Gent, ID Barbier, SL Atkin, AE Newell-Fugate, AC Swart Journal of Chromatography B 1215, 123576, 2023 | 4 | 2023 |
Androstenedione is the preferred substrate for cytochrome P450 11β-hydroxylase leading to the production of 11β-hydroxyandrostenedione in the adrenal gland ID Barbier, R Gent, T Du Toit, AC Swart Journal of the Endocrine Society 5 (Suppl 1), A65, 2021 | 4 | 2021 |
C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors R Gent, D Van Rooyen, SL Atkin, AC Swart International Journal of Molecular Sciences 25 (1), 101, 2023 | 1 | 2023 |
The metabolism and receptor interactions of C11-oxy steroids: Implications for hormonal homeostasis and pathophysiology R Gent Stellenbosch University, 2024 | | 2024 |
CYP11B and CYP17A1 in the Biosynthesis and Metabolism of C11‐oxy Steroids AC Swart, D van Rooyen, R Gent, T du Toit The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |
SAT-344 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrgenase Inhibitor, Is Metabolised In Vitro by Adrenal Steroidogenic Enzymes R Gent, A Swart Journal of the Endocrine Society 3 (Supplement_1), SAT-344, 2019 | | 2019 |
11α-Hydroxyprogesterone, a potent 11ß-hydroxysteroid R Gent, T du Toit, AC Swart | | 2019 |
Adrenal C11-oxy C21 steroids contribute to the C11-oxy L Barnard, R Gent, D van Rooyen Endocr. Rev 21, 245-291, 2000 | | 2000 |