TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS KM Cunningham, K Maulding, K Ruan, M Senturk, JC Grima, H Sung, ... Elife 9, e59419, 2020 | 47 | 2020 |
Identification of therapeutic targets for amyotrophic lateral sclerosis using PandaOmics–an AI-enabled biological target discovery platform FW Pun, BHM Liu, X Long, HW Leung, GHD Leung, QT Mewborne, J Gao, ... Frontiers in Aging Neuroscience 14, 914017, 2022 | 36 | 2022 |
A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila JL Gao, YJ Fan, XY Wang, Y Zhang, J Pu, L Li, W Shao, S Zhan, J Hao, ... Genes & development 29 (7), 760-771, 2015 | 33 | 2015 |
Divergence, convergence, and therapeutic implications: a cell biology perspective of C9ORF72-ALS/FTD X Tang, A Toro, S TG, J Gao, J Chalk, BE Oskarsson, K Zhang Molecular neurodegeneration 15, 1-15, 2020 | 25 | 2020 |
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy B Khalil, D Chhangani, MC Wren, CL Smith, JH Lee, X Li, C Puttinger, ... Molecular neurodegeneration 17 (1), 80, 2022 | 14 | 2022 |
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins J Gao, QT Mewborne, A Girdhar, U Sheth, AN Coyne, R Punathil, ... Science translational medicine 14 (662), eabq3215, 2022 | 12 | 2022 |
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Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy Y Min, X Wang, Ö İş, TA Patel, J Gao, JS Reddy, ZS Quicksall, T Nguyen, ... Nature communications 14 (1), 6801, 2023 | 3 | 2023 |
Network‐based pipeline guides knowledge‐driven prioritization and validation of therapeutic target discovery for Alzheimer’s disease Y Min, X Wang, J Gao, C Zhang, C Ung, JL Chalk, C Correia, TE Golde, ... Alzheimer's & Dementia 19, e073832, 2023 | | 2023 |