| Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells B Handyside, AM Ismail, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, ... Molecular Therapy 30 (12), 3570-3586, 2022 | 16 | 2022 |
| Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood L Zhang, B Yates, R Murphy, S Liu, L Xie, B Handyside, CR Sihn, ... Molecular Therapy-Methods & Clinical Development 26, 519-531, 2022 | 3 | 2022 |
| Prophylactic Prednisolone Promotes AAV5 Hepatocyte Transduction Through the Novel Mechanism of AAV5 Coreceptor Platelet-Derived Growth Factor Receptor Alpha Upregulation and … B Handyside, L Zhang, B Yates, L Xie, AM Ismail, R Murphy, B Baridon, ... Human Gene Therapy 35 (1-2), 36-47, 2024 | | 2024 |
| Prophylactic prednisolone promotes AAV5 hepatocyte transduction through the novel mechanism of AAV5 co-receptor PDGFRα upregulation and innate immune suppression. B Handyside, L Zhang, B Yates, L Xie, MI Ashrafali, R Murphy, B Baridon, ... Human Gene Therapy, 2023 | | 2023 |
| The effect of prophylactic corticosteroid treatment on adeno-associated virus-mediated gene therapy and potential mechanisms of action B Handyside, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, T Bouwman, ... Hämostaseologie 43 (S 01), T-13-05, 2023 | | 2023 |
| Prophylactic corticosteroid treatment in mice improved AAV5 transgene expression through multiple mechanisms B Handyside, B Yates, L Zhang, AM Ismail, L Xie, CR Sihn, R Murphy, ... HUMAN GENE THERAPY 33 (23-24), A161-A161, 2022 | | 2022 |
| Vector genome loss and epigenetic modifications impact long-term transgene expression of AAV5 vectors produced in mammalian HEK293 and insect Sf cells A Ismail, B Handyside, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, ... HUMAN GENE THERAPY 33 (23-24), A19-A20, 2022 | | 2022 |
| 915. Impact of Genome Accessibility and Long-Term Expression of Adeno-Associated Virus 5 Produced in Mammalian (HEK293) and Insect (Sf) Cell Lines AM Ismail, B Handyside, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, ... Molecular Therapy 30 (4S1), 2022 | | 2022 |
| The Effect of Prophylactic Corticosteroid Treatment on Adeno-Associated Virus-Mediated Gene Therapy and Potential Mechanisms of Action B Handyside, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, T Bouwman, ... MOLECULAR THERAPY 30 (4), 444-445, 2022 | | 2022 |
| Long-term Expression Comparison of Adeno-Associated Virus (AAV) Vector Produced in HEK293 vs Sf Cell Lines B Handyside, L Zhang, B Yates, L Xie, CR Sihn, R Murphy, T Bouwman, ... MOLECULAR THERAPY 29 (4), 118-118, 2021 | | 2021 |
