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Giorgio Basile
Giorgio Basile
Joslin Diabetes Center
Verified email at joslin.harvard.edu
Title
Cited by
Cited by
Year
Loss-of-function mutations in APPL1 in familial diabetes mellitus
S Prudente, P Jungtrakoon, A Marucci, O Ludovico, P Buranasupkajorn, ...
The American Journal of Human Genetics 97 (1), 177-185, 2015
1802015
Human duct cells contribute to β cell compensation in insulin resistance
E Dirice, DF De Jesus, S Kahraman, G Basile, RWS Ng, A El Ouaamari, ...
JCI insight 4 (8), 2019
492019
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes
E Dirice, S Kahraman, DF De Jesus, A El Ouaamari, G Basile, RL Baker, ...
Nature metabolism 1 (5), 509-518, 2019
432019
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
DF De Jesus, K Orime, D Kaminska, T Kimura, G Basile, CH Wang, ...
The Journal of clinical investigation 130 (5), 2391-2407, 2020
422020
How, when, and where do human β-cells regenerate?
G Basile, RN Kulkarni, NG Morgan
Current diabetes reports 19, 1-12, 2019
402019
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor-and IGF-1 receptor-independent pathway
J Shirakawa, K Tajima, T Okuyama, M Kyohara, Y Togashi, DF De Jesus, ...
Diabetologia 63, 577-587, 2020
292020
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
S Kahraman, E Dirice, G Basile, D Diegisser, J Alam, BB Johansson, ...
Nature Metabolism 4 (1), 76-89, 2022
272022
Emerging diabetes therapies: Bringing back the β-cells
G Basile, MMF Qadir, F Mauvais-Jarvis, A Vetere, V Shoba, AE Modell, ...
Molecular Metabolism 60, 101477, 2022
222022
Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
G Basile, S Kahraman, E Dirice, H Pan, JM Dreyfuss, RN Kulkarni
Genome medicine 13 (1), 128, 2021
222021
Identification and clinical characterization of adult patients with multigenerational diabetes mellitus
O Ludovico, M Carella, L Bisceglia, G Basile, S Mastroianno, A Palena, ...
PLoS One 10 (8), e0135855, 2015
182015
E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance
J Shirakawa, Y Togashi, G Basile, T Okuyama, R Inoue, M Fernandez, ...
Cell reports 41 (1), 2022
152022
Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes
S Prudente, D Bailetti, C Mendonca, GC Mannino, A Fontana, F Andreozzi, ...
Atherosclerosis 242 (1), 334-339, 2015
122015
Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion
A El Ouaamari, O InSug, J Shirakawa, G Basile, W Zhang, S Roger, ...
Journal of Biological Chemistry 294 (3), 1059-1069, 2019
112019
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
G Basile, A Vetere, J Hu, O Ijaduola, Y Zhang, KC Liu, AM Eltony, ...
Cell metabolism 35 (7), 1242-1260. e9, 2023
42023
Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance
E Dirice, G Basile, S Kahraman, D Diegisser, J Hu, RN Kulkarni
JCI insight 7 (16), 2022
42022
Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
DF De Jesus, Z Zhang, NK Brown, X Li, MJ Gaffrey, S Kahraman, J Wei, ...
bioRxiv, 2023.02. 16.528701, 2023
12023
Identification of Pancreatic Elastase Inhibitors That Can Stimulate Beta-Cell Proliferation
G Basile, A Vetere, J Hu, B Wagner, R Kulkarni
Diabetes 67 (Supplement_1), 2018
12018
Mutations in APPL1 gene may contribute to familial diabetes mellitus
S Prudente, P Jungtrakoon, A Marucci, O Ludovico, T Mazza, T Hastings, ...
Diabetes, 2014
12014
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
D F. De Jesus, Z Zhang, NK Brown, X Li, L Xiao, J Hu, MJ Gaffrey, ...
Nature Cell Biology, 1-17, 2024
2024
198-OR: Pancreatic Elastase Regulates Human Beta-Cell Viability by Impairing the PAR2 Pathway
G BASILE, A VETERE, J HU, DF DE JESUS, A CHOUDHARY, ...
Diabetes 72 (Supplement_1), 2023
2023
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