| Mechanisms of drug combinations: interaction and network perspectives J Jia, F Zhu, X Ma, ZW Cao, YX Li, YZ Chen Nature reviews Drug discovery 8 (2), 111-128, 2009 | 970 | 2009 |
| SVM-Prot: web-based support vector machine software for functional classification of a protein from its primary sequence CZ Cai, LY Han, ZL Ji, X Chen, YZ Chen Nucleic acids research 31 (13), 3692-3697, 2003 | 739 | 2003 |
| TTD: therapeutic target database X Chen, ZL Ji, YZ Chen Nucleic acids research 30 (1), 412-415, 2002 | 738 | 2002 |
| Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery F Zhu, Z Shi, C Qin, L Tao, X Liu, F Xu, L Zhang, Y Song, X Liu, J Zhang, ... Nucleic acids research 40 (D1), D1128-D1136, 2012 | 533 | 2012 |
| Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics YH Li, CY Yu, XX Li, P Zhang, J Tang, Q Yang, T Fu, X Zhang, X Cui, G Tu, ... Nucleic acids research 46 (D1), D1121-D1127, 2018 | 504 | 2018 |
| Ligand–protein inverse docking and its potential use in the computer search of protein targets of a small molecule YZ Chen, DG Zhi Proteins: Structure, Function, and Bioinformatics 43 (2), 217-226, 2001 | 473 | 2001 |
| PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence ZR Li, HH Lin, LY Han, L Jiang, X Chen, YZ Chen Nucleic acids research 34 (suppl_2), W32-W37, 2006 | 381 | 2006 |
| NOREVA: normalization and evaluation of MS-based metabolomics data B Li, J Tang, Q Yang, S Li, X Cui, Y Li, Y Chen, W Xue, X Li, F Zhu Nucleic acids research 45 (W1), W162-W170, 2017 | 334 | 2017 |
| HIT: linking herbal active ingredients to targets H Ye, L Ye, H Kang, D Zhang, L Tao, K Tang, X Liu, R Zhu, Q Liu, ... Nucleic acids research 39 (suppl_1), D1055-D1059, 2010 | 330 | 2010 |
| Update of TTD: therapeutic target database F Zhu, BC Han, P Kumar, XH Liu, XH Ma, XN Wei, L Huang, YF Guo, ... Nucleic acids research 38 (suppl_1), D787-D791, 2010 | 315 | 2010 |
| Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information H Yang, C Qin, YH Li, L Tao, J Zhou, CY Yu, F Xu, Z Chen, F Zhu, ... Nucleic acids research 44 (D1), D1069-D1074, 2016 | 284 | 2016 |
| Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting F Zhu, C Qin, L Tao, X Liu, Z Shi, X Ma, J Jia, Y Tan, C Cui, J Lin, C Tan, ... Proceedings of the National Academy of Sciences 108 (31), 12943-12948, 2011 | 284 | 2011 |
| Enzyme family classification by support vector machines CZ Cai, LY Han, ZL Ji, YZ Chen Proteins: Structure, Function, and Bioinformatics 55 (1), 66-76, 2004 | 240 | 2004 |
| Prediction of P-glycoprotein substrates by a support vector machine approach Y Xue, CW Yap, LZ Sun, ZW Cao, JF Wang, YZ Chen Journal of chemical information and computer sciences 44 (4), 1497-1505, 2004 | 227 | 2004 |
| What contributes to serotonin–norepinephrine reuptake inhibitors’ dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine … W Xue, F Yang, P Wang, G Zheng, Y Chen, X Yao, F Zhu ACS Chemical Neuroscience 9 (5), 1128-1140, 2018 | 226 | 2018 |
| Therapeutic targets: progress of their exploration and investigation of their characteristics CJ Zheng, LY Han, CW Yap, ZL Ji, ZW Cao, YZ Chen Pharmacological reviews 58 (2), 259-279, 2006 | 220 | 2006 |
| Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation X Chen, H Zhou, YB Liu, JF Wang, H Li, CY Ung, LY Han, ZW Cao, ... British journal of pharmacology 149 (8), 1092-1103, 2006 | 214 | 2006 |
| Effect of molecular descriptor feature selection in support vector machine classification of pharmacokinetic and toxicological properties of chemical agents Y Xue, ZR Li, CW Yap, LZ Sun, X Chen, YZ Chen Journal of chemical information and computer sciences 44 (5), 1630-1638, 2004 | 210 | 2004 |
| NPASS: natural product activity and species source database for natural product research, discovery and tool development X Zeng, P Zhang, W He, C Qin, S Chen, L Tao, Y Wang, Y Tan, D Gao, ... Nucleic acids research 46 (D1), D1217-D1222, 2018 | 204 | 2018 |
| Prediction of cytochrome P450 3A4, 2D6, and 2C9 inhibitors and substrates by using support vector machines CW Yap, YZ Chen Journal of chemical information and modeling 45 (4), 982-992, 2005 | 199 | 2005 |
