| Design of amidobenzimidazole STING receptor agonists with systemic activity JM Ramanjulu, GS Pesiridis, J Yang, N Concha, R Singhaus, SY Zhang, ... Nature 564 (7736), 439-443, 2018 | 564 | 2018 |
| Exploiting machine learning for end-to-end drug discovery and development S Ekins, AC Puhl, KM Zorn, TR Lane, DP Russo, JJ Klein, AJ Hickey, ... Nature materials 18 (5), 435-441, 2019 | 439 | 2019 |
| Déjà vu: stimulating open drug discovery for SARS-CoV-2 S Ekins, M Mottin, PRPS Ramos, BKP Sousa, BJ Neves, DH Foil, KM Zorn, ... Drug discovery today 25 (5), 928-941, 2020 | 110 | 2020 |
| Mode of peroxisome proliferator-activated receptor γ activation by luteolin AC Puhl, A Bernardes, RL Silveira, J Yuan, JLO Campos, ... Molecular pharmacology 81 (6), 788-799, 2012 | 108 | 2012 |
| Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs AC Puhl, FA Milton, A Cvoro, DH Sieglaff, JCL Campos, A Bernardes, ... Nuclear receptor signaling 13 (1), nrs. 13004, 2015 | 91 | 2015 |
| Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms AC Puhl, EJ Fritch, TR Lane, LV Tse, BL Yount, CQ Sacramento, ... ACS omega 6 (11), 7454-7468, 2021 | 71 | 2021 |
| Identification of a new hormone-binding site on the surface of thyroid hormone receptor PCT Souza, AC Puhl, L Martínez, R Aparício, AS Nascimento, ... Molecular endocrinology 28 (4), 534-545, 2014 | 45 | 2014 |
| Machine learning models identify inhibitors of SARS-CoV-2 VO Gawriljuk, PPK Zin, AC Puhl, KM Zorn, DH Foil, TR Lane, B Hurst, ... Journal of chemical information and modeling 61 (9), 4224-4235, 2021 | 43 | 2021 |
| Recent advances in drug repurposing using machine learning F Urbina, AC Puhl, S Ekins Current opinion in chemical biology 65, 74-84, 2021 | 40 | 2021 |
| Inhibition of inositol polyphosphate kinases by quercetin and related flavonoids: A structure–activity analysis C Gu, MA Stashko, AC Puhl-Rubio, M Chakraborty, A Chakraborty, ... Journal of medicinal chemistry 62 (3), 1443-1454, 2019 | 40 | 2019 |
| Preparation and characterization of polymeric nanoparticles loaded with the flavonoid luteolin, by using factorial design. AC Puhl, M Fagundes, KC Dos Santos, I Polikarpov, MFD Graças, ... International journal of drug delivery 3 (4), 683, 2011 | 40 | 2011 |
| Stealth and non-stealth nanocapsules containing camptothecin: in-vitro and in-vivo activity on B16-F10 melanoma G Loch-Neckel, D Nemen, AC Puhl, D Fernandes, MA Stimamiglio, ... Journal of Pharmacy and Pharmacology 59 (10), 1359-1364, 2007 | 32 | 2007 |
| Covalent immobilization of tobacco‐etch‐virus NIa protease: a useful tool for cleavage of the histidine tag of recombinant proteins AC Puhl, C Giacomini, G Irazoqui, F Batista‐Viera, A Villarino, H Terenzi Biotechnology and applied biochemistry 53 (3), 165-174, 2009 | 26 | 2009 |
| Machine learning for discovery of GSK3β inhibitors PA Vignaux, E Minerali, DH Foil, AC Puhl, S Ekins ACS omega 5 (41), 26551-26561, 2020 | 24 | 2020 |
| New targets for HIV drug discovery AC Puhl, AG Demo, VA Makarov, S Ekins Drug discovery today 24 (5), 1139-1147, 2019 | 24 | 2019 |
| Use of protein kinase–focused compound libraries for the discovery of new inositol phosphate kinase inhibitors AC Puhl-Rubio, MA Stashko, H Wang, PB Hardy, V Tyagi, B Li, X Wang, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (9), 982-988, 2018 | 21 | 2018 |
| Development of machine learning models and the discovery of a new antiviral compound against yellow fever virus VO Gawriljuk, DH Foil, AC Puhl, KM Zorn, TR Lane, O Riabova, ... Journal of chemical information and modeling 61 (8), 3804-3813, 2021 | 20 | 2021 |
| Discovery and development of cyclic peptide inhibitors of CIB1 VA Haberman, SR Fleming, TM Leisner, AC Puhl, E Feng, L Xie, X Chen, ... ACS Medicinal Chemistry Letters 12 (11), 1832-1839, 2021 | 18 | 2021 |
| Pyronaridine protects against SARS-CoV-2 infection in mouse AC Puhl, GF Gomes, S Damasceno, AS Godoy, GD Noske, AM Nakamura, ... ACS Infectious Diseases 8 (6), 1147-1160, 2022 | 15 | 2022 |
| The antiviral drug tilorone is a potent and selective inhibitor of acetylcholinesterase PA Vignaux, E Minerali, TR Lane, DH Foil, PB Madrid, AC Puhl, S Ekins Chemical research in toxicology 34 (5), 1296-1307, 2021 | 15 | 2021 |
sean ekinsCollaborations Pharmaceuticals, Inc.Verified email at collaborationspharma.com
