A small-molecule inhibitor of Bax and Bak oligomerization prevents genotoxic cell death and promotes neuroprotection X Niu, H Brahmbhatt, P Mergenthaler, Z Zhang, J Sang, M Daude, ... Cell chemical biology 24 (4), 493-506. e5, 2017 | 93 | 2017 |
Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins JM Pemberton, JP Pogmore, DW Andrews Cell Death & Differentiation 28 (1), 108-122, 2021 | 59 | 2021 |
Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 Q Liu, EJ Osterlund, X Chi, J Pogmore, B Leber, DW Andrews Elife 8, e37689, 2019 | 58 | 2019 |
Allosteric regulation of BH3 proteins in Bcl-xL complexes enables switch-like activation of Bax C Bogner, J Kale, J Pogmore, X Chi, A Shamas-Din, C Fradin, B Leber, ... Molecular Cell 77 (4), 901-912. e9, 2020 | 36 | 2020 |
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣ membrane F Lv, F Qi, Z Zhang, M Wen, J Kale, A Piai, L Du, S Wang, L Zhou, Y Yang, ... The EMBO journal 40 (14), e106438, 2021 | 23 | 2021 |
Pharmacological targeting of executioner proteins: controlling life and death JP Pogmore, D Uehling, DW Andrews Journal of medicinal chemistry 64 (9), 5276-5290, 2021 | 21 | 2021 |
Using Förster-Resonance energy transfer to measure protein interactions between Bcl-2 family proteins on mitochondrial membranes JP Pogmore, JM Pemberton, X Chi, DW Andrews Programmed Cell Death: Methods and Protocols, 197-212, 2016 | 14 | 2016 |
A small-molecule inhibitor of bax and bak oligomerization prevents genotoxic cell death and promotes neuroprotection. Cell Chem Biol 24 (4): 493–506 e495 X Niu, H Brahmbhatt, P Mergenthaler, Z Zhang, J Sang, M Daude, ... | 2 | 2017 |
The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes JM Pemberton, D Nguyen, EJ Osterlund, W Schormann, JP Pogmore, ... Elife 12, e88329, 2023 | 1 | 2023 |
Signaling Mechanism and Pharmacological Manipulation of Bcl-2 Family Proteins in Apoptosis JP Pogmore University of Toronto (Canada), 2021 | | 2021 |
11th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration J Pogmore, J Longo, D Resetca, N Farivar, NA Buckley, MG Rincón, ... Cell Death & Disease 10 (12), 926, 2019 | | 2019 |