| Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir Y Hu, EM Lewandowski, H Tan, X Zhang, RT Morgan, X Zhang, ... ACS central science 9 (8), 1658-1669, 2023 | 144 | 2023 |
| Discovery of di-and trihaloacetamides as covalent SARS-CoV-2 main protease inhibitors with high target specificity C Ma, Z Xia, MD Sacco, Y Hu, JA Townsend, X Meng, J Choza, H Tan, ... Journal of the American Chemical Society 143 (49), 20697-20709, 2021 | 103 | 2021 |
| Progress and challenges in targeting the SARS-CoV-2 papain-like protease H Tan, Y Hu, P Jadhav, B Tan, J Wang Journal of medicinal chemistry 65 (11), 7561-7580, 2022 | 88 | 2022 |
| Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays C Ma, H Tan, J Choza, Y Wang, J Wang Acta Pharmaceutica Sinica B 12 (4), 1636-1651, 2022 | 59 | 2022 |
| SARS-CoV-2 main protease drug design, assay development, and drug resistance studies B Tan, R Joyce, H Tan, Y Hu, J Wang Accounts of chemical research 56 (2), 157-168, 2022 | 45 | 2022 |
| An overview of antivirals against monkeypox virus and other orthopoxviruses J Wang, M Shahed-AI-Mahmud, A Chen, K Li, H Tan, R Joyce Journal of medicinal chemistry 66 (7), 4468-4490, 2023 | 16 | 2023 |
| Invalidation of dieckol and 1, 2, 3, 4, 6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor H Tan, C Ma, J Wang Medicinal Chemistry Research 31 (7), 1147-1153, 2022 | 15 | 2022 |
| Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors B Tan, M Sacco, H Tan, K Li, R Joyce, X Zhang, Y Chen, J Wang European Journal of Medicinal Chemistry 259, 115667, 2023 | 11 | 2023 |
| A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations J Ou, EM Lewandowski, Y Hu, AA Lipinski, A Aljasser, M Colon-Ascanio, ... PLoS pathogens 19 (8), e1011592, 2023 | 11 | 2023 |
| Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant … CJ Cáceres, Y Hu, S Cárdenas-García, X Wu, H Tan, S Carnaccini, ... Emerging Microbes & Infections 10 (1), 1832-1848, 2021 | 10 | 2021 |
| Telaprevir treatment reduces paralysis in a mouse model of enterovirus D68 acute flaccid myelitis J Frost, MJ Rudy, JS Leser, H Tan, Y Hu, J Wang, P Clarke, KL Tyler Journal of virology 97 (5), e00156-23, 2023 | 7 | 2023 |
| A benzopyran with antiarrhythmic activity is an inhibitor of Kir3. 1-containing potassium channels M Cui, Y Alhamshari, L Cantwell, EIH Said, GC Eptaminitaki, M Chang, ... Journal of Biological Chemistry 296, 2021 | 7 | 2021 |
| Structure-based design of SARS-CoV-2 papain-like protease inhibitors P Jadhav, B Huang, J Osipiuk, X Zhang, H Tan, C Tesar, M Endres, ... European Journal of Medicinal Chemistry 264, 116011, 2024 | 3 | 2024 |
| FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 Mpro and PLpro H Tan, Y Hu, J Wang STAR protocols 4 (2), 102323, 2023 | 3 | 2023 |
| Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model B Tan, X Zhang, A Ansari, P Jadhav, H Tan, K Li, A Chopra, A Ford, X Chi, ... Science 383 (6690), 1434-1440, 2024 | 2 | 2024 |
| Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance EM Lewandowski, X Zhang, H Tan, A Jaskolka-Brown, N Kohaal, ... bioRxiv, 2024.04. 01.587566, 2024 | | 2024 |
| Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors B Tan, C Liu, K Li, P Jadhav, G Lambrinidis, L Zhu, L Olson, H Tan, Y Wen, ... Journal of medicinal chemistry 66 (21), 14544-14563, 2023 | | 2023 |
| Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model (preprint) B Tan, X Zhang, A Ansari, P Jadhav, H Tan, K Li, A Chopra, A Ford, X Chi, ... | | 2023 |
| Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir (preprint) Y Hu, EM Lewandowski, H Tan, RT Morgan, X Zhang, LM Jacobs, ... | | 2022 |
| A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations (preprint) J Ou, E Lewandowski, Y Hu, A Lipinski, R Morgan, L Jacobs, X Zhang, ... | | 2022 |
