Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi CJ Henderson, CR Wolf, N Kitteringham, H Powell, D Otto, BK Park Proceedings of the National Academy of Sciences 97 (23), 12741-12745, 2000 | 282 | 2000 |
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver NR Kitteringham, A Abdullah, J Walsh, L Randle, RE Jenkins, R Sison, ... Journal of proteomics 73 (8), 1612-1631, 2010 | 207 | 2010 |
Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity BK Park, NR Kitteringham, H Powell, M Pirmohamed Toxicology 153 (1-3), 39-60, 2000 | 161 | 2000 |
Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype. H Powell, NR Kitteringham, M Pirmohamed, DA Smith, BK Park Pharmacogenetics 8 (5), 411-421, 1998 | 122 | 1998 |
Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia EU Griese, KF Ilett, NR Kitteringham, M Eichelbaum, H Powell, ... Pharmacogenetics and Genomics 11 (1), 69-76, 2001 | 80 | 2001 |
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications J Walsh, RE Jenkins, M Wong, A Olayanju, H Powell, I Copple, PM O’Neill, ... Journal of proteomics 108, 171-187, 2014 | 77 | 2014 |
The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs L Faulkner, K Martinsson, A Santoyo-Castelazo, K Cederbrant, ... Toxicological Sciences 127 (1), 150-158, 2012 | 76 | 2012 |
Hepatocellular response to chemical stress in CD‐1 mice: Induction of early genes and γ‐glutamylcysteine synthetase NR Kitteringham, H Powell, YN Clement, CC Dodd, JN Tettey, ... Hepatology 32 (2), 321-333, 2000 | 73 | 2000 |
Protein expression profiling of glutathione S‐transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol‐induced toxicity in the … NR Kitteringham, H Powell, RE Jenkins, J Hamlett, C Lovatt, R Elsby, ... Proteomics 3 (2), 191-207, 2003 | 47 | 2003 |
Epigenetics–relevance to drug safety science CC Priestley, M Anderton, AT Doherty, P Duffy, HR Mellor, H Powell, ... Toxicology Research 1 (1), 23-31, 2012 | 20 | 2012 |
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey H Yu, N Barrass, S Gales, E Lenz, T Parry, H Powell, D Thurman, ... Xenobiotica 45 (3), 270-277, 2015 | 13 | 2015 |
Protection against paracetamol hepatotoxicity in glutathione S-transferase pi knockout mice does not involve altered covalent binding NR Kitteringham, H Powell, CJ Henderson, CR Wolf, BK Park British Journal of Clinical Pharmacology 48 (6), 887P-888P, 1999 | 4 | 1999 |
The role of the transcription factor Nrf2 in lipid metabolism in the liver J Walsh, NR Kitteringham, JL Griffin, CEP Goldring, S Williams, H Powell, ... Toxicology 2 (290), 140-141, 2011 | 1 | 2011 |
A longitudinal study assessing lens thickness changes in the eye of the growing beagle using ultrasound scanning: relevance to age of dogs in regulatory toxicology studies J Maynard, A Sykes, H Powell, G Healing, M Scott, A Holmes, SA Ricketts, ... Journal of Applied Toxicology 34 (12), 1368-1372, 2014 | | 2014 |
Evaluation of paracetamol toxicity in the cynomolgus monkey H YU, N BARRASS, S GALES, E LENZ, D WESTON, I WILSONB, ... 中国药理学与毒理学杂志 3, 225, 2013 | | 2013 |
Chemical, biological, and toxicological mechanisms of hepatotoxins C Hirst, E Dalton-Brown, D Williams, J Maggs, H Powell, J Harding, ... DRUG METABOLISM REVIEWS 38, 169-170, 2006 | | 2006 |
Transcriptional response to glutathione depletion H Powell, NR Kitteringham, Y Clement, C O'Donnell, C Goldring, ... Toxicology 148 (1), 71-72, 2000 | | 2000 |
Molecular aspects of xenobiotic toxicity: role of bioactivation and bioinactivation. H Powell University of Liverpool, 1999 | | 1999 |