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Helen Powell
Helen Powell
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Cited by
Cited by
Year
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi
CJ Henderson, CR Wolf, N Kitteringham, H Powell, D Otto, BK Park
Proceedings of the National Academy of Sciences 97 (23), 12741-12745, 2000
2822000
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
NR Kitteringham, A Abdullah, J Walsh, L Randle, RE Jenkins, R Sison, ...
Journal of proteomics 73 (8), 1612-1631, 2010
2072010
Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity
BK Park, NR Kitteringham, H Powell, M Pirmohamed
Toxicology 153 (1-3), 39-60, 2000
1612000
Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.
H Powell, NR Kitteringham, M Pirmohamed, DA Smith, BK Park
Pharmacogenetics 8 (5), 411-421, 1998
1221998
Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia
EU Griese, KF Ilett, NR Kitteringham, M Eichelbaum, H Powell, ...
Pharmacogenetics and Genomics 11 (1), 69-76, 2001
802001
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications
J Walsh, RE Jenkins, M Wong, A Olayanju, H Powell, I Copple, PM O’Neill, ...
Journal of proteomics 108, 171-187, 2014
772014
The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs
L Faulkner, K Martinsson, A Santoyo-Castelazo, K Cederbrant, ...
Toxicological Sciences 127 (1), 150-158, 2012
762012
Hepatocellular response to chemical stress in CD‐1 mice: Induction of early genes and γ‐glutamylcysteine synthetase
NR Kitteringham, H Powell, YN Clement, CC Dodd, JN Tettey, ...
Hepatology 32 (2), 321-333, 2000
732000
Protein expression profiling of glutathione S‐transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol‐induced toxicity in the …
NR Kitteringham, H Powell, RE Jenkins, J Hamlett, C Lovatt, R Elsby, ...
Proteomics 3 (2), 191-207, 2003
472003
Epigenetics–relevance to drug safety science
CC Priestley, M Anderton, AT Doherty, P Duffy, HR Mellor, H Powell, ...
Toxicology Research 1 (1), 23-31, 2012
202012
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
H Yu, N Barrass, S Gales, E Lenz, T Parry, H Powell, D Thurman, ...
Xenobiotica 45 (3), 270-277, 2015
132015
Protection against paracetamol hepatotoxicity in glutathione S-transferase pi knockout mice does not involve altered covalent binding
NR Kitteringham, H Powell, CJ Henderson, CR Wolf, BK Park
British Journal of Clinical Pharmacology 48 (6), 887P-888P, 1999
41999
The role of the transcription factor Nrf2 in lipid metabolism in the liver
J Walsh, NR Kitteringham, JL Griffin, CEP Goldring, S Williams, H Powell, ...
Toxicology 2 (290), 140-141, 2011
12011
A longitudinal study assessing lens thickness changes in the eye of the growing beagle using ultrasound scanning: relevance to age of dogs in regulatory toxicology studies
J Maynard, A Sykes, H Powell, G Healing, M Scott, A Holmes, SA Ricketts, ...
Journal of Applied Toxicology 34 (12), 1368-1372, 2014
2014
Evaluation of paracetamol toxicity in the cynomolgus monkey
H YU, N BARRASS, S GALES, E LENZ, D WESTON, I WILSONB, ...
中国药理学与毒理学杂志 3, 225, 2013
2013
Chemical, biological, and toxicological mechanisms of hepatotoxins
C Hirst, E Dalton-Brown, D Williams, J Maggs, H Powell, J Harding, ...
DRUG METABOLISM REVIEWS 38, 169-170, 2006
2006
Transcriptional response to glutathione depletion
H Powell, NR Kitteringham, Y Clement, C O'Donnell, C Goldring, ...
Toxicology 148 (1), 71-72, 2000
2000
Molecular aspects of xenobiotic toxicity: role of bioactivation and bioinactivation.
H Powell
University of Liverpool, 1999
1999
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Articles 1–18