Dante Rotili, PhD
Dante Rotili, PhD
Professor of Medicinal Chemistry, "Sapienza" University of Rome
Verified email at - Homepage
Cited by
Cited by
Histone deacetylation in epigenetics: an attractive target for anticancer therapy
A Mai, S Massa, D Rotili, I Cerbara, S Valente, R Pezzi, S Simeoni, ...
Medicinal research reviews 25 (3), 261-309, 2005
Sirtuin functions and modulation: from chemistry to the clinic
V Carafa, D Rotili, M Forgione, F Cuomo, E Serretiello, GS Hailu, E Jarho, ...
Clinical epigenetics 8, 1-21, 2016
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
E Lara, A Mai, V Calvanese, L Altucci, P Lopez-Nieva, ...
Oncogene 28 (6), 781-791, 2009
SIRT5 regulation of ammonia-induced autophagy and mitophagy
L Polletta, E Vernucci, I Carnevale, T Arcangeli, D Rotili, S Palmerio, ...
Autophagy 11 (2), 253-270, 2015
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
A Galmozzi, N Mitro, A Ferrari, E Gers, F Gilardi, C Godio, G Cermenati, ...
diabetes 62 (3), 732-742, 2013
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl) pyrrolyl hydroxyamides
A Mai, S Massa, R Pezzi, S Simeoni, D Rotili, A Nebbioso, ...
Journal of medicinal chemistry 48 (9), 3344-3353, 2005
Targeting histone demethylases: a new avenue for the fight against cancer
D Rotili, A Mai
Genes & cancer 2 (6), 663-679, 2011
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes
A Nebbioso, F Manzo, M Miceli, M Conte, L Manente, A Baldi, A De Luca, ...
EMBO reports 10 (7), 776-782, 2009
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties
A Mai, D Rotili, D Tarantino, P Ornaghi, F Tosi, C Vicidomini, G Sbardella, ...
Journal of medicinal chemistry 49 (23), 6897-6907, 2006
Structural basis of sirtuin 6 activation by synthetic small molecules
W You, D Rotili, TM Li, C Kambach, M Meleshin, M Schutkowski, KF Chua, ...
Angewandte Chemie International Edition 56 (4), 1007-1011, 2017
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities
D Rotili, S Tomassi, M Conte, R Benedetti, M Tortorici, G Ciossani, ...
Journal of medicinal chemistry 57 (1), 42-55, 2014
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling
B Illi, CD Russo, C Colussi, J Rosati, M Pallaoro, F Spallotta, D Rotili, ...
Circulation research 102 (1), 51-58, 2008
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases
G Sbardella, S Castellano, C Vicidomini, D Rotili, A Nebbioso, M Miceli, ...
Bioorganic & medicinal chemistry letters 18 (9), 2788-2792, 2008
" Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line modelsá…
A Savarino, A Mai, S Norelli, S El Daker, S Valente, D Rotili, L Altucci, ...
Retrovirology 6, 1-10, 2009
Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans
A Mai, D Rotili, S Massa, G Brosch, G Simonetti, C Passariello, ...
Bioorganic & Medicinal Chemistry Letters 17 (5), 1221-1225, 2007
p300/CBP-associated factor selectively regulates the extinction of conditioned fear
W Wei, CM Coelho, X Li, R Marek, S Yan, S Anderson, D Meyers, ...
Journal of Neuroscience 32 (35), 11930-11941, 2012
Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases
A Mai, D Rotili, D Tarantino, A Nebbioso, S Castellano, G Sbardella, ...
Bioorganic & medicinal chemistry letters 19 (4), 1132-1135, 2009
Epigenetic polypharmacology: A new frontier for epi‐drug discovery
D Tomaselli, A Lucidi, D Rotili, A Mai
Medicinal research reviews 40 (1), 190-244, 2020
Development of 1, 2, 4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure–activity relationship, X-ray crystal structure, andá…
S Moniot, M Forgione, A Lucidi, GS Hailu, A Nebbioso, V Carafa, F Baratta, ...
Journal of medicinal chemistry 60 (6), 2344-2360, 2017
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells
D Rotili, D Tarantino, A Nebbioso, C Paolini, C Huidobro, E Lara, P Mellini, ...
Journal of medicinal chemistry 55 (24), 10937-10947, 2012
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