Norman E. Sharpless
Norman E. Sharpless
Former Director, The National Cancer Institute
Verified email at
Cited by
Cited by
Circular RNAs are abundant, conserved, and associated with ALU repeats
WR Jeck, JA Sorrentino, K Wang, MK Slevin, CE Burd, J Liu, WF Marzluff, ...
Rna 19 (2), 141-157, 2013
Genomic classification of cutaneous melanoma
R Akbani, KC Akdemir, B ŠArman Aksoy, M Albert, A Ally, SB Amin, ...
Cell 161 (7), 1681-1696, 2015
Detecting and characterizing circular RNAs
WR Jeck, NE Sharpless
Nature biotechnology 32 (5), 453-461, 2014
Ink4a/Arf expression is a biomarker of aging
J Krishnamurthy, C Torrice, MR Ramsey, GI Kovalev, K Al-Regaiey, L Su, ...
The Journal of clinical investigation 114 (9), 1299-1307, 2004
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
J Chang, Y Wang, L Shao, RM Laberge, M Demaria, J Campisi, ...
Nature medicine 22 (1), 78-83, 2016
Senescence in health and disease
S He, NE Sharpless
Cell 169 (6), 1000-1011, 2017
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
V Janzen, R Forkert, HE Fleming, Y Saito, MT Waring, DM Dombkowski, ...
Nature 443 (7110), 421-426, 2006
The regulation of INK4/ARF in cancer and aging
WY Kim, NE Sharpless
Cell 127 (2), 265-275, 2006
LKB1 modulates lung cancer differentiation and metastasis
H Ji, MR Ramsey, DN Hayes, C Fan, K McNamara, P Kozlowski, C Torrice, ...
Nature 448 (7155), 807-810, 2007
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discov.
M Demaria, MN O’leary, J Chang, L Shao, S Liu, F Alimirah, K Koenig, ...
CD-16-0241.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 2017
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
AV Molofsky, SG Slutsky, NM Joseph, S He, R Pardal, J Krishnamurthy, ...
Nature 443 (7110), 448-452, 2006
p16INK4a induces an age-dependent decline in islet regenerative potential
J Krishnamurthy, MR Ramsey, KL Ligon, C Torrice, A Koh, S Bonner-Weir, ...
Nature 443 (7110), 453-457, 2006
How stem cells age and why this makes us grow old
NE Sharpless, RA DePinho
Nature reviews Molecular cell biology 8 (9), 703-713, 2007
Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr
Nature Reviews Cancer 15 (7), 397-408, 2015
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
NE Sharpless, N Bardeesy, KH Lee, D Carrasco, DH Castrillon, ...
Nature 413 (6851), 86-91, 2001
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
CE Burd, WR Jeck, Y Liu, HK Sanoff, Z Wang, NE Sharpless
PLoS genetics 6 (12), e1001233, 2010
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
RM Bachoo, EA Maher, KL Ligon, NE Sharpless, SS Chan, MJ You, ...
Cancer cell 1 (3), 269-277, 2002
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
The mighty mouse: genetically engineered mouse models in cancer drug development
NE Sharpless, RA DePinho
Nature reviews Drug discovery 5 (9), 741-754, 2006
The INK4A/ARF locus and its two gene products
NE Sharpless, RA DePinho
Current opinion in genetics & development 9 (1), 22-30, 1999
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