Norman E. Sharpless
Norman E. Sharpless
Former Director, The National Cancer Institute
Verified email at - Homepage
Cited by
Cited by
Circular RNAs are abundant, conserved, and associated with ALU repeats
WR Jeck, JA Sorrentino, K Wang, MK Slevin, CE Burd, J Liu, WF Marzluff, ...
Rna 19 (2), 141-157, 2013
Genomic classification of cutaneous melanoma
R Akbani, KC Akdemir, BA Aksoy, M Albert, A Ally, SB Amin, H Arachchi, ...
Cell 161 (7), 1681-1696, 2015
Detecting and characterizing circular RNAs
WR Jeck, NE Sharpless
Nature biotechnology 32 (5), 453-461, 2014
Ink4a/Arf expression is a biomarker of aging
J Krishnamurthy, C Torrice, MR Ramsey, GI Kovalev, K Al-Regaiey, L Su, ...
The Journal of clinical investigation 114 (9), 1299-1307, 2004
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
J Chang, Y Wang, L Shao, RM Laberge, M Demaria, J Campisi, ...
Nature medicine 22 (1), 78-83, 2016
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
V Janzen, R Forkert, HE Fleming, Y Saito, MT Waring, DM Dombkowski, ...
Nature 443 (7110), 421-426, 2006
The Regulation of INK4/ARF in Cancer and Aging
WY Kim, NE Sharpless
Cell 127 (2), 265-275, 2006
LKB1 modulates lung cancer differentiation and metastasis
H Ji, MR Ramsey, DN Hayes, C Fan, K McNamara, P Kozlowski, C Torrice, ...
Nature 448 (7155), 807-810, 2007
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
AV Molofsky, SG Slutsky, NM Joseph, S He, R Pardal, J Krishnamurthy, ...
Nature 443 (7110), 448-452, 2006
p16INK4a induces an age-dependent decline in islet regenerative potential
J Krishnamurthy, MR Ramsey, KL Ligon, C Torrice, A Koh, S Bonner-Weir, ...
Nature 443 (7110), 453-457, 2006
How stem cells age and why this makes us grow old
NE Sharpless, RA DePinho
Nature reviews Molecular cell biology 8 (9), 703-713, 2007
Senescence in health and disease
S He, NE Sharpless
Cell 169 (6), 1000-1011, 2017
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
NE Sharpless, N Bardeesy, KH Lee, D Carrasco, DH Castrillon, ...
Nature 413 (6851), 86-91, 2001
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
CE Burd, WR Jeck, Y Liu, HK Sanoff, Z Wang, NE Sharpless
PLoS genetics 6 (12), e1001233, 2010
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discov.
M Demaria, MN O’leary, J Chang, L Shao, S Liu, F Alimirah, K Koenig, ...
CD-16-0241.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 2017
Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr
Nature Reviews Cancer 15 (7), 397-408, 2015
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
RM Bachoo, EA Maher, KL Ligon, NE Sharpless, SS Chan, MJ You, ...
Cancer cell 1 (3), 269-277, 2002
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
The mighty mouse: genetically engineered mouse models in cancer drug development
NE Sharpless, RA DePinho
Nature reviews Drug discovery 5 (9), 741-754, 2006
The INK4A/ARF locus and its two gene products
NE Sharpless, RA DePinho
Current opinion in genetics & development 9 (1), 22-30, 1999
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