Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening S Shishodia, R Nuñez, BP Strohmier, KL Bursch, CJ Goetz, MD Olp, ... Journal of Medicinal Chemistry 65 (20), 13714-13735, 2022 | 11 | 2022 |
Fragment-based screening by protein-detected NMR spectroscopy. PJ Kerber, R Nuñez, DR Jensen, AL Zhou, FC Peterson, RB Hill, ... Methods in Enzymology 690, 285-310, 2023 | 2 | 2023 |
Cancer-associated Polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression KL Bursch, CJ Goetz, G Jiao, R Nuñez, MD Olp, A Dhiman, M Khurana, ... Journal of Biological Chemistry, 107146, 2024 | | 2024 |
TRIM33 as a novel reader of metabolically-derived histone lactylation R Nunez, B Smith Journal of Biological Chemistry 299 (3), S534, 2023 | | 2023 |
Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function K Bursch, C Goetz, R Nuñez, G Jiao, M Olp, S Jorge, R Urrutia, ... Journal of Biological Chemistry 299 (3), S705-S706, 2023 | | 2023 |
Polybromo‐1 missense mutations found in renal cancer patients affect bromodomain stability and biological function G Jiao, C Goetz, K Bursch, R Nuñez, M Olp, M Zimmerman, R Urrutia, ... The FASEB Journal 36, 2022 | | 2022 |
Zinc‐Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β‐Cells RA Jones Lipinski, JS Stancill, SL Wynia‐Smith, DJ Sprague, R Nunez, ... The FASEB Journal 36, 2022 | | 2022 |