A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer JM Park, YJ Kim, S Park, M Park, L Farrand, CT Nguyen, J Ann, G Nam, ... Molecular Cancer 19, 1-8, 2020 | 46 | 2020 |
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition TM Cho, JY Kim, YJ Kim, D Sung, E Oh, S Jang, L Farrand, VH Hoang, ... Cancer letters 447, 141-153, 2019 | 45 | 2019 |
A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects HJ Lee, HY Min, YS Yong, J Ann, CT Nguyen, MT La, SY Hyun, HT Le, ... Theranostics 12 (1), 105, 2022 | 36 | 2022 |
Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer SY Hyun, HT Le, CT Nguyen, YS Yong, HJ Boo, HJ Lee, JS Lee, HY Min, ... Scientific reports 8 (1), 13924, 2018 | 35 | 2018 |
Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors HS Kim, M Hong, J Ann, S Yoon, CT Nguyen, SC Lee, HY Lee, YG Suh, ... Bioorganic & Medicinal Chemistry 24 (22), 6082-6093, 2016 | 30 | 2016 |
Investigation of B, C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents HS Kim, VH Hoang, M Hong, KC Kim, J Ann, CT Nguyen, JH Seo, H Choi, ... Bioorganic & Medicinal Chemistry 27 (7), 1370-1381, 2019 | 23 | 2019 |
A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response JY Kim, TM Cho, JM Park, S Park, M Park, KD Nam, D Ko, J Seo, S Kim, ... Oncogene 41 (23), 3289-3297, 2022 | 22 | 2022 |
The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells S Park, YJ Kim, JM Park, M Park, KD Nam, L Farrand, CT Nguyen, MT La, ... Cell death discovery 7 (1), 354, 2021 | 21 | 2021 |
Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer CT Nguyen, MT La, J Ann, G Nam, HJ Park, JM Park, YJ Kim, JY Kim, ... Bioorganic & Medicinal Chemistry Letters 45, 128134, 2021 | 15 | 2021 |
Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90) CT Nguyen, J Ann, R Sahu, WS Byun, S Lee, G Nam, HJ Park, S Park, ... Bioorganic & Medicinal Chemistry Letters 30 (17), 127374, 2020 | 15 | 2020 |
The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer M Park, E Jung, JM Park, S Park, D Ko, J Seo, S Kim, K Dal Nam, ... Theranostics 14 (6), 2442, 2024 | 4 | 2024 |
Stability Constant and Potentiometric Sensitivity of Heavy Metal–Organic Fluorescent Compound Complexes: QSPR Models for Prediction and Design of Novel Coumarin-like Ligands PT Diem-Tran, TT Ho, NV Tuan, LQ Bao, HT Phuong, TTG Chau, ... Toxics 11 (7), 595, 2023 | 2 | 2023 |
Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents MT La, VH Hoang, R Sahu, CT Nguyen, G Nam, HJ Park, M Park, YJ Kim, ... European Journal of Medicinal Chemistry 276, 116620, 2024 | | 2024 |