| Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13 J Liu, H Xia, M Kim, L Xu, Y Li, L Zhang, Y Cai, HV Norberg, T Zhang, ... Cell 147 (1), 223-234, 2011 | 807 | 2011 |
| Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte RP Norris, WJ Ratzan, M Freudzon, LM Mehlmann, J Krall, MA Movsesian, ... Oxford University Press for The Company of Biologists Limited 136 (11), 1869 …, 2009 | 596 | 2009 |
| Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development H Wang, Y Liu, Q Huai, J Cai, R Zoraghi, SH Francis, JD Corbin, ... Journal of Biological Chemistry 281 (30), 21469-21479, 2006 | 177 | 2006 |
| Crystal structure of DJ-1/RS and implication on familial Parkinson’s disease Q Huai, Y Sun, H Wang, LS Chin, L Li, H Robinson, H Ke FEBS letters 549 (1-3), 171-175, 2003 | 155 | 2003 |
| Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity H Ke, H Wang Current topics in medicinal chemistry 7 (4), 391-403, 2007 | 154 | 2007 |
| Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity Q Huai, H Wang, Y Sun, HY Kim, Y Liu, H Ke Structure 11 (7), 865-873, 2003 | 151 | 2003 |
| High-resolution design of a protein loop X Hu, H Wang, H Ke, B Kuhlman Proceedings of the National Academy of Sciences 104 (45), 17668-17673, 2007 | 144 | 2007 |
| Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding H Wang, JR Falck, TMT Hall, SB Shears Nature chemical biology 8 (1), 111-116, 2012 | 137 | 2012 |
| Structural insight into substrate specificity of phosphodiesterase 10 H Wang, Y Liu, J Hou, M Zheng, H Robinson, H Ke Proceedings of the National Academy of Sciences 104 (14), 5782-5787, 2007 | 130 | 2007 |
| A correlation between TCR Vα docking on MHC and CD8 dependence: implications for T cell selection J Buslepp, H Wang, WE Biddison, E Appella, EJ Collins Immunity 19 (4), 595-606, 2003 | 130 | 2003 |
| Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors H Wang, MS Peng, Y Chen, J Geng, H Robinson, MD Houslay, J Cai, ... Biochemical Journal 408 (2), 193-201, 2007 | 126 | 2007 |
| Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding Q Huai, H Wang, W Zhang, RW Colman, H Robinson, H Ke Proceedings of the National Academy of Sciences 101 (26), 9624-9629, 2004 | 119 | 2004 |
| Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding Q Huai, H Wang, Y Liu, HY Kim, D Toft, H Ke Structure 13 (4), 579-590, 2005 | 111 | 2005 |
| Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7 H Wang, Y Liu, Y Chen, H Robinson, H Ke Journal of Biological Chemistry 280 (35), 30949-30955, 2005 | 103 | 2005 |
| Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity H Wang, Z Yan, S Yang, J Cai, H Robinson, H Ke Biochemistry 47 (48), 12760-12768, 2008 | 90 | 2008 |
| Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling X Li, C Gu, S Hostachy, S Sahu, C Wittwer, HJ Jessen, D Fiedler, H Wang, ... Proceedings of the National Academy of Sciences 117 (7), 3568-3574, 2020 | 82 | 2020 |
| Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors T Castaño, H Wang, NE Campillo, S Ballester, C González‐García, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (5), 866-876, 2009 | 79 | 2009 |
| Synthesis of Densely Phosphorylated Bis‐1,5‐Diphospho‐myo‐Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P‐Anhydride Formation S Capolicchio, H Wang, DT Thakor, SB Shears, HJ Jessen Angewandte Chemie 126 (36), 9662-9665, 2014 | 77 | 2014 |
| Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite‐selective inhibitors H Wang, Z Yan, J Geng, S Kunz, T Seebeck, H Ke Molecular microbiology 66 (4), 1029-1038, 2007 | 76 | 2007 |
| KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype C Gu, HN Nguyen, D Ganini, Z Chen, HJ Jessen, Z Gu, H Wang, ... Proceedings of the National Academy of Sciences 114 (45), 11968-11973, 2017 | 74 | 2017 |
