Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition Y Cohen-Sharir, JM McFarland, M Abdusamad, C Marquis, SV Bernhard, ... Nature 590 (7846), 486-491, 2021 | 160 | 2021 |
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy MR Ippolito, V Martis, S Martin, AE Tijhuis, C Hong, R Wardenaar, ... Developmental cell 56 (17), 2440-2454. e6, 2021 | 96 | 2021 |
Aneuploidy-driven genome instability triggers resistance to chemotherapy MR Ippolito, V Martis, C Hong, R Wardenaar, J Zerbib, DCJ Spierings, ... Biorxiv, 2020.09. 25.313924, 2020 | 11 | 2020 |
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage J Zerbib, MR Ippolito, Y Eliezer, G De Feudis, E Reuveni, AS Kadmon, ... bioRxiv, 2023.01. 27.525822, 2023 | 9 | 2023 |
Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model K Oved, L Zennaro, O Dorot, J Zerbib, E Frank, LN Roux, ... Biochemical and biophysical research communications 582, 100-104, 2021 | 6 | 2021 |
Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture D Stavish, CJ Price, G Gelezauskaite, KA Leonhard, SM Taapken, ... bioRxiv, 2023.09. 21.558777, 2023 | 2 | 2023 |
Computationally engineered CRISPR-SpyCas9 high-fidelity variants with improved specificity and reduced non-specific DNA damage R Rabinowitz, O Shor, J Zerbib, S Herman, N Zelikson, S Mediwale, ... bioRxiv, 2023.04. 11.536265, 2023 | 1 | 2023 |
Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells MR Ippolito, J Zerbib, Y Eliezer, E Reuveni, S Viganò, G De Feudis, ... bioRxiv, 2023.01. 27.525826, 2023 | 1 | 2023 |
Aneuploid cells depend on the RAF/MEK/ERK pathway and on RNA degradation for overcoming DNA damage and transcriptional burden MR Ippolito, JZ Zerbib, Y Eliezer, E Reuveni, S Viganò, G De Feudis, ... Cancer Research 84 (6_Supplement), 413-413, 2024 | | 2024 |
Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas NU Nair, AA Schaffer, ME Gertz, K Cheng, J Zerbib, AD Sahu, G Leor, ... bioRxiv, 2024.01. 17.576103, 2024 | | 2024 |
A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer V Rendo, M Schubert, N Khuu, MF Suarez Peredo Rodriguez, K Huang, ... bioRxiv, 2023.12. 16.571980, 2023 | | 2023 |
Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism K Laue, S Pozzi, Y Cohen-Sharir, T Winkler, Y Eliezer, S Israeli Dangoor, ... bioRxiv, 2023.12. 20.572490, 2023 | | 2023 |