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John T. Walker
John T. Walker
Children's Hospital of Philadelphia
Verified email at chop.edu
Title
Cited by
Cited by
Year
Ectonucleoside triphosphate diphosphohydrolase-3 antibody targets adult human pancreatic β cells for in vitro and in vivo analysis
DC Saunders, M Brissova, N Phillips, S Shrestha, JT Walker, ...
Cell metabolism 29 (3), 745-754. e4, 2019
662019
The human islet: mini-organ with mega-impact
JT Walker, DC Saunders, M Brissova, AC Powers
Endocrine reviews 42 (5), 605-657, 2021
602021
Tacrolimus-and sirolimus-induced human β cell dysfunction is reversible and preventable
C Dai, JT Walker, A Shostak, A Padgett, E Spears, S Wisniewski, ...
JCI insight 5 (1), 2020
582020
Lipid droplet accumulation in human pancreatic islets is dependent on both donor age and health
X Tong, C Dai, JT Walker, GG Nair, A Kennedy, RM Carr, M Hebrok, ...
Diabetes 69 (3), 342-354, 2020
462020
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells
JT Walker, R Haliyur, HA Nelson, M Ishahak, G Poffenberger, ...
JCI insight 5 (10), 2020
402020
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
S Shrestha, DC Saunders, JT Walker, J Camunas-Soler, XQ Dai, ...
JCI Insight 6 (18), e151621, 2021
242021
Dapagliflozin does not directly affect human α or β cells
C Dai, JT Walker, A Shostak, Y Bouchi, G Poffenberger, NJ Hart, ...
Endocrinology 161 (8), bqaa080, 2020
142020
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes
JT Walker, DC Saunders, V Rai, C Dai, P Orchard, AL Hopkirk, ...
BioRxiv, 2021.12. 16.466282, 2021
82021
Genetic risk converges on regulatory networks mediating early type 2 diabetes.
JT Walker, DC Saunders, V Rai, HH Chen, P Orchard, C Dai, YD Pettway, ...
Nature, 2023
22023
Integrated analysis of the pancreas and islets reveals unexpected findings in human male with type 1 diabetes
R Haliyur, JT Walker, M Sanyoura, CV Reihsmann, S Shrestha, ...
Journal of the Endocrine Society 5 (12), bvab162, 2021
12021
New Insights into the Molecular Mechanisms of Islet Dysfunction in Human Diabetes
JT Walker
12021
Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
TM Richardson, YD Pettway, JT Walker, HA Nelson, M Ishahak, ...
JoVE (Journal of Visualized Experiments), e65259, 2023
2023
231-OR: Reduced NKX2-2 Expression Enhances Insulin Secretion by Primary Human ß-Cells
YD PETTWAY, J WALKER, C DAI, R ARAMANDLA, AL HOPKIRK, ...
Diabetes 72 (Supplement_1), 2023
2023
367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D
YD Pettway, C Dai, TM Richardson, JT Walker, R Aramandla, ...
Diabetes 71 (Supplement_1), 2022
2022
44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose
JT WALKER, R HALIYUR, R ARAMANDLA, G POFFENBERGER, ...
Diabetes 68 (Supplement_1), 2019
2019
107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α-and ß-Cell Subpopulations
S Shrestha, DC Saunders, JT Walker, R Haliyur, G Poffenberger, ...
Diabetes 68 (Supplement_1), 2019
2019
Pancreatic Islets in Short Duration Type 2 Diabetes (T2D) Show Macrophage Infiltration and Increased Inflammatory Signaling
JT Walker, S Shrestha, N Prasad, T Richardson, R Aramandla, ...
Diabetes 67 (Supplement_1), 2018
2018
Pancreatic Islets in Short-Duration Type 2 Diabetes Have Secretory Dysfunction, Variable Amyloid Accumulation, and Altered Islet-Enriched Transcription Factor Expression
JT Walker, D Saunders, S Shrestha, N Prasad, SE Levy, R Aramandla, ...
DIABETES 66, A577-A577, 2017
2017
Integrated human pseudoislet system and microfluidic platform demonstrates differences in G-protein-coupled-receptor signaling in islet cells
JT Walker, AC Powers, M Brissova
Insulin 2, 4, 0
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Articles 1–19