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Malek Okour
Malek Okour
Director, Clinical Pharmacology, Servier
Verified email at servier.com - Homepage
Title
Cited by
Cited by
Year
Mycophenolic acid and its metabolites in kidney transplant recipients: a semimechanistic enterohepatic circulation model to improve estimating exposure
M Okour, PA Jacobson, MA Ahmed, AK Israni, RC Brundage
The Journal of Clinical Pharmacology 58 (5), 628-639, 2018
332018
Modeling enterohepatic circulation
M Okour, RC Brundage
Current Pharmacology Reports 3, 301-313, 2017
212017
Hydroxychloroquine and azithromycin as potential treatments for COVID-19; clinical status impacts the outcome
M Okour, M Al-Kofahi, D Austin
Journal of pharmacokinetics and pharmacodynamics 47, 187-188, 2020
202020
Orphan drug development: the increasing role of clinical pharmacology
MA Ahmed, M Okour, R Brundage, RV Kartha
Journal of Pharmacokinetics and Pharmacodynamics 46, 395-409, 2019
172019
A randomized study of safety and efficacy of two doses of ambrisentan to treat pulmonary arterial hypertension in pediatric patients aged 8 years up to 18 years
D Ivy, M Beghetti, E Juaneda-Simian, D Miller, MA Lukas, C Ioannou, ...
The Journal of Pediatrics: X 5, 100055, 2020
142020
Drug combination modeling: methods and applications in drug development
RA Pearson, SG Wicha, M Okour
The Journal of Clinical Pharmacology 63 (2), 151-165, 2023
132023
A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers
M Okour, G Derimanov, R Barnett, E Fernandez, S Ferrer, S Gresham, ...
British Journal of Clinical Pharmacology 84 (3), 482-489, 2018
102018
A population analysis of the DGAT1 inhibitor GSK3008356 and its effect on endogenous and meal‐induced triglyceride turnover in healthy subjects
M Okour, RA Brigandi, D Tenero
Fundamental & Clinical Pharmacology 33 (5), 567-580, 2019
72019
Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure–Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite
M Okour, PA Jacobson, A Israni, RC Brundage
European journal of drug metabolism and pharmacokinetics 44, 629-638, 2019
62019
Evaluation of Potential Therapeutic Options for COVID‐19.
D Austin, M Okour
Journal of clinical pharmacology 60 (8), 2020
52020
Population pharmacokinetic analysis of fluticasone furoate/umeclidinium bromide/vilanterol in patients with chronic obstructive pulmonary disease
R Mehta, C Farrell, S Hayes, R Birk, M Okour, DA Lipson
Clinical Pharmacokinetics 59, 67-79, 2020
52020
Rapid antibody responses to Epstein-Barr virus correlate with reduced severity of primary infection
JM Geris, AL Stancari, MR Meirhaeghe, S Gautam, C Cayatte, ...
Journal of Clinical Virology 155, 105267, 2022
42022
A gallbladder-based enterohepatic circulation model for pharmacokinetic studies
M Okour, RC Brundage
European Journal of Drug Metabolism and Pharmacokinetics 44, 493-504, 2019
42019
DosePredict: A shiny application for generalized pharmacokinetics‐based dose predictions
M Okour
The Journal of Clinical Pharmacology 60 (11), 1502-1508, 2020
32020
Population pharmacokinetic/pharmacodynamic analysis of intravenous zanamivir in healthy adults and hospitalized adult and pediatric subjects with influenza
P Zuo, J Collins, M Okour, A Barth, D Shortino, P Yates, G Roberts, ...
Clinical and Translational Science 13 (1), 157-168, 2020
32020
First‐in‐Human Pharmacokinetics and Safety Study of GSK3008356, a Selective DGAT1 Inhibitor, in Healthy Volunteers
M Okour, A Gress, X Zhu, D Rieman, JD Lickliter, RA Brigandi
Clinical Pharmacology in Drug Development 8 (8), 1088-1099, 2019
32019
A phase I study to show the relative bioavailability and bioequivalence of fixed-dose combinations of ambrisentan and tadalafil in healthy subjects
M Okour, A Puri, G Chen, K Port, A Berni, S Khindri, I Schneider, D Tenero
Clinical Therapeutics 41 (6), 1110-1127, 2019
22019
The Pharmacokinetics of Enterohepatic Circulation
MF Okour
University of Minnesota, 2015
22015
Pediatric Population Pharmacokinetic Modeling and Exposure–Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data
M Okour, MM Thapar, C Farrell, MA Lukas, M Beghetti, M Beerahee
The Journal of Clinical Pharmacology 63 (5), 593-603, 2023
12023
Safety and Pharmacokinetics of the Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Administered by Intravenous Injection in Japanese and Caucasian Healthy Volunteers
A Okamasa, M Okour, D Austin, Y Shida, JE Sager, E Alexander, ...
Kansenshogaku Zasshi, 39-45, 2022
12022
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