| Quantitative flux analysis reveals folate-dependent NADPH production J Fan, J Ye, JJ Kamphorst, T Shlomi, CB Thompson, JD Rabinowitz Nature 510 (7504), 298-302, 2014 | 1038 | 2014 |
| The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation J Ye, M Kumanova, LS Hart, K Sloane, H Zhang, DN De Panis, ... The EMBO journal 29 (12), 2082-2096, 2010 | 711 | 2010 |
| p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells A Tarangelo, L Magtanong, KT Bieging-Rolett, Y Li, J Ye, LD Attardi, ... Cell reports 22 (3), 569-575, 2018 | 441 | 2018 |
| Serine catabolism regulates mitochondrial redox control during hypoxia J Ye, J Fan, S Venneti, YW Wan, BR Pawel, J Zhang, LWS Finley, C Lu, ... Cancer discovery 4 (12), 1406-1417, 2014 | 427 | 2014 |
| Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation J Ye, A Mancuso, X Tong, PS Ward, J Fan, JD Rabinowitz, CB Thompson Proceedings of the National Academy of Sciences 109 (18), 6904-6909, 2012 | 404 | 2012 |
| PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage E Bobrovnikova-Marjon, C Grigoriadou, D Pytel, F Zhang, J Ye, ... Oncogene 29 (27), 3881-3895, 2010 | 355 | 2010 |
| GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2 J Ye, W Palm, M Peng, B King, T Lindsten, MO Li, C Koumenis, ... Genes & development 29 (22), 2331-2336, 2015 | 260 | 2015 |
| ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression F Tameire, II Verginadis, NM Leli, C Polte, CS Conn, R Ojha, ... Nature cell biology 21 (7), 889-899, 2019 | 190 | 2019 |
| Induction of sarcomas by mutant IDH2 C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ... Genes & development 27 (18), 1986-1998, 2013 | 177 | 2013 |
| Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways DR Fels, J Ye, AT Segan, SJ Kridel, M Spiotto, M Olson, AC Koong, ... Cancer research 68 (22), 9323-9330, 2008 | 164 | 2008 |
| ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis J Ye, C Koumenis Current molecular medicine 9 (4), 411-416, 2009 | 151 | 2009 |
| Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell–Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium G Ikeda, MR Santoso, Y Tada, AM Li, E Vaskova, JH Jung, C O’Brien, ... Journal of the American College of Cardiology 77 (8), 1073-1088, 2021 | 107 | 2021 |
| The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor Y Xiao, KN Thakkar, H Zhao, J Broughton, Y Li, JA Seoane, AN Diep, ... Proceedings of the National Academy of Sciences 117 (35), 21441-21449, 2020 | 71 | 2020 |
| Metabolic profiling reveals a dependency of human metastatic breast cancer on mitochondrial serine and one-carbon unit metabolism AM Li, GS Ducker, Y Li, JA Seoane, Y Xiao, S Melemenidis, Y Zhou, L Liu, ... Molecular Cancer Research 18 (4), 599-611, 2020 | 69 | 2020 |
| Reprogramming of serine, glycine and one-carbon metabolism in cancer AM Li, J Ye Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (10), 165841, 2020 | 67 | 2020 |
| Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor … X Tian, J Ye, M Alonso-Basanta, SM Hahn, C Koumenis, JF Dorsey Journal of Biological Chemistry 286 (33), 29408-29416, 2011 | 63 | 2011 |
| A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression II Verginadis, H Avgousti, J Monslow, G Skoufos, F Chinga, K Kim, ... Nature Cell Biology 24 (6), 940-953, 2022 | 59 | 2022 |
| SnapShot: cancer metabolism pathways LWS Finley, J Zhang, J Ye, PS Ward, CB Thompson Cell metabolism 17 (3), 466-466. e2, 2013 | 58 | 2013 |
| Hypoxia and the unfolded protein response C Koumenis, M Bi, J Ye, D Feldman, AC Koong Methods in enzymology 435, 275-293, 2007 | 48 | 2007 |
| Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia Y Li, JJ Gruber, UM Litzenburger, Y Zhou, YR Miao, EL LaGory, AM Li, ... Cell Death & Disease 11 (2), 102, 2020 | 46 | 2020 |
Constantinos KoumenisDepartment of Radiation Oncology, University of Pennsylvania School of MedicineVerified email at upenn.edu
