| Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth BW Murray, C Guo, J Piraino, JK Westwick, C Zhang, J Lamerdin, ... Proceedings of the National Academy of Sciences 107 (20), 9446-9451, 2010 | 330 | 2010 |
| 3, 5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation I McAlpine, J Deal, M Johnson, S Kephart, J Park, W Romines, J Tikhe US Patent App. 10/910,217, 2005 | 161 | 2005 |
| Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation SH Reich, TM Bleckman, SE Kephart, WH Romines, MB Wallace US Patent 6,555,539, 2003 | 157 | 2003 |
| Silicon-directed aldol reactions. Rate acceleration by small rings AG Myers, SE Kephart, H Chen Journal of the American Chemical Society 114 (20), 7922-7923, 1992 | 143 | 1992 |
| Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: identification of development candidate (R … PP Kung, P Bingham, A Brooun, M Collins, YL Deng, D Dinh, C Fan, ... Journal of medicinal chemistry 61 (3), 650-665, 2018 | 105 | 2018 |
| 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation SE Kephart, IJ Mcalpine, SH Reich US Patent 7,008,953, 2006 | 99 | 2006 |
| Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one … H Cheng, SK Nair, BW Murray, C Almaden, S Bailey, S Baxi, D Behenna, ... Journal of Medicinal Chemistry 59 (5), 2005-2024, 2016 | 98 | 2016 |
| Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation SH Reich, TM Bleckman, SE Kephart, WH Romines, MB Wallace US Patent 6,919,461, 2005 | 97 | 2005 |
| Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation SH Reich, TM Bleckman, SE Kephart, WH Romines III, MB Wallace US Patent 7,232,912, 2007 | 94 | 2007 |
| Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor K Freeman-Cook, RL Hoffman, N Miller, J Almaden, J Chionis, Q Zhang, ... Cancer cell 39 (10), 1404-1421. e11, 2021 | 93 | 2021 |
| 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation S Kephart, I McAlpine, S Reich US Patent App. 11/237,446, 2006 | 93 | 2006 |
| Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation S Reich, T Bleckman, S Kephart, W Romines, M Wallace US Patent App. 11/329,303, 2006 | 91 | 2006 |
| Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO) A Linton, P Kang, M Ornelas, S Kephart, Q Hu, M Pairish, Y Jiang, C Guo Journal of medicinal chemistry 54 (21), 7705-7712, 2011 | 82 | 2011 |
| Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists C Guo, A Linton, S Kephart, M Ornelas, M Pairish, J Gonzalez, S Greasley, ... Journal of medicinal chemistry 54 (21), 7693-7704, 2011 | 78 | 2011 |
| Discovery of pyrroloaminopyrazoles as novel PAK inhibitors C Guo, I McAlpine, J Zhang, DD Knighton, S Kephart, MC Johnson, H Li, ... Journal of medicinal chemistry 55 (10), 4728-4739, 2012 | 77 | 2012 |
| Pyrazole compounds as RAF inhibitors JJ Cui, JG Deal, D Gu, C Guo, MC Johnson, RS Kania, SE Kephart, ... US Patent 7,772,246, 2010 | 72 | 2010 |
| Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors PP Kung, E Rui, S Bergqvist, P Bingham, J Braganza, M Collins, M Cui, ... Journal of medicinal chemistry 59 (18), 8306-8325, 2016 | 67 | 2016 |
| Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation SH Reich, T Johnson, MB Wallace, SE Kephart, SA Fuhrman, ST Worland, ... Journal of Medicinal Chemistry 43 (9), 1670-1683, 2000 | 65 | 2000 |
| Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer KD Freeman-Cook, RL Hoffman, DC Behenna, B Boras, J Carelli, W Diehl, ... Journal of Medicinal Chemistry 64 (13), 9056-9077, 2021 | 63 | 2021 |
| Discovery of 2-((1H-benzo [d] imidazol-1-yl) methyl)-4H-pyrido [1, 2-a] pyrimidin-4-ones as novel PKM2 activators C Guo, A Linton, M Jalaie, S Kephart, M Ornelas, M Pairish, S Greasley, ... Bioorganic & medicinal chemistry letters 23 (11), 3358-3363, 2013 | 56 | 2013 |
