| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13122* | 2021 |
| TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD CC Chou, YI Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, ... Nature neuroscience 21 (2), 228-239, 2018 | 488 | 2018 |
| Substrate-targeting γ-secretase modulators TL Kukar, TB Ladd, MA Bann, PC Fraering, R Narlawar, GM Maharvi, ... Nature 453 (7197), 925-929, 2008 | 377 | 2008 |
| Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production T Kukar, MP Murphy, JL Eriksen, SA Sagi, S Weggen, TE Smith, T Ladd, ... Nature medicine 11 (5), 545-550, 2005 | 351 | 2005 |
| FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage Q Deng, CJ Holler, G Taylor, KF Hudson, W Watkins, M Gearing, D Ito, ... Journal of Neuroscience 34 (23), 7802-7813, 2014 | 163 | 2014 |
| Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice T Kukar, S Prescott, JL Eriksen, V Holloway, MP Murphy, EH Koo, ... BMC neuroscience 8, 1-12, 2007 | 160 | 2007 |
| Protein microarrays to detect protein–protein interactions using red and green fluorescent proteins T Kukar, S Eckenrode, Y Gu, W Lian, M Megginson, JX She, D Wu Analytical biochemistry 306 (1), 50-54, 2002 | 145 | 2002 |
| Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains BD Moore, P Chakrabarty, Y Levites, TL Kukar, AM Baine, T Moroni, ... Alzheimer's research & therapy 4, 1-15, 2012 | 123 | 2012 |
| Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells X Chen, J Chang, Q Deng, J Xu, TA Nguyen, LH Martens, B Cenik, ... Journal of neuroscience 33 (21), 9202-9213, 2013 | 114 | 2013 |
| Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN mutations CJ Holler, G Taylor, Q Deng, T Kukar Eneuro 4 (4), 2017 | 113 | 2017 |
| Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis J Root, P Merino, A Nuckols, M Johnson, T Kukar Neurobiology of disease 154, 105360, 2021 | 112 | 2021 |
| Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia CJ Holler, G Taylor, ZT McEachin, Q Deng, WJ Watkins, K Hudson, ... Molecular neurodegeneration 11, 1-17, 2016 | 95 | 2016 |
| Independent generation of Aβ42 and Aβ38 peptide species by γ-secretase E Czirr, BA Cottrell, S Leuchtenberger, T Kukar, TB Ladd, H Esselmann, ... Journal of biological chemistry 283 (25), 17049-17054, 2008 | 90 | 2008 |
| Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis C Verbeeck, Q Deng, M DeJesus-Hernandez, G Taylor, C Ceballos-Diaz, ... Molecular neurodegeneration 7, 1-13, 2012 | 86 | 2012 |
| Structure of human carnitine acetyltransferase: molecular basis for fatty acyl transfer D Wu, L Govindasamy, W Lian, Y Gu, T Kukar, M Agbandje-McKenna, ... Journal of Biological Chemistry 278 (15), 13159-13165, 2003 | 86 | 2003 |
| Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1) JD Shi, T Kukar, CY Wang, QZ Li, PE Cruz, A Davoodi-Semiromi, P Yang, ... Journal of Biological Chemistry 276 (20), 17474-17478, 2001 | 85 | 2001 |
| Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: Support for a sequential model of γ-secretase intramembrane proteolysis … TL Kukar, TB Ladd, P Robertson, SA Pintchovski, B Moore, MA Bann, ... Journal of Biological Chemistry 286 (46), 39804-39812, 2011 | 82 | 2011 |
| Short Aβ peptides attenuate Aβ42 toxicity in vivo BD Moore, J Martin, L de Mena, J Sanchez, PE Cruz, C Ceballos-Diaz, ... Journal of Experimental Medicine 215 (1), 283-301, 2018 | 71 | 2018 |
| Possible mechanisms of action of NSAIDs and related compounds that modulate γ-secretase cleavage T Kukar, TE Golde Current topics in medicinal chemistry 8 (1), 47-53, 2008 | 71 | 2008 |
| Molecular signatures of neuroinflammation induced by αsynuclein aggregates in microglial cells S Sarkar, EB Dammer, E Malovic, AL Olsen, SA Raza, T Gao, H Xiao, ... Frontiers in immunology 11, 33, 2020 | 64 | 2020 |
Todd GoldeEmory UniversityVerified email at emory.edu
