Thomas Kukar
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
CC Chou, YI Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, ...
Nature neuroscience 21 (2), 228-239, 2018
Substrate-targeting γ-secretase modulators
TL Kukar, TB Ladd, MA Bann, PC Fraering, R Narlawar, GM Maharvi, ...
Nature 453 (7197), 925-929, 2008
Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production
T Kukar, MP Murphy, JL Eriksen, SA Sagi, S Weggen, TE Smith, T Ladd, ...
Nature medicine 11 (5), 545-550, 2005
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice
T Kukar, S Prescott, JL Eriksen, V Holloway, MP Murphy, EH Koo, ...
BMC neuroscience 8 (1), 1-12, 2007
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage
Q Deng, CJ Holler, G Taylor, KF Hudson, W Watkins, M Gearing, D Ito, ...
Journal of Neuroscience 34 (23), 7802-7813, 2014
Protein microarrays to detect protein–protein interactions using red and green fluorescent proteins
T Kukar, S Eckenrode, Y Gu, W Lian, M Megginson, JX She, D Wu
Analytical biochemistry 306 (1), 50-54, 2002
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
BD Moore, P Chakrabarty, Y Levites, TL Kukar, AM Baine, T Moroni, ...
Alzheimer's research & therapy 4 (3), 1-15, 2012
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells
X Chen, J Chang, Q Deng, J Xu, TA Nguyen, LH Martens, B Cenik, ...
Journal of neuroscience 33 (21), 9202-9213, 2013
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN mutations
CJ Holler, G Taylor, Q Deng, T Kukar
Eneuro 4 (4), 2017
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
CJ Holler, G Taylor, ZT McEachin, Q Deng, WJ Watkins, K Hudson, ...
Molecular neurodegeneration 11, 1-17, 2016
Independent generation of Aβ42 and Aβ38 peptide species by γ-secretase
E Czirr, BA Cottrell, S Leuchtenberger, T Kukar, TB Ladd, H Esselmann, ...
Journal of Biological Chemistry 283 (25), 17049-17054, 2008
Structure of human carnitine acetyltransferase: molecular basis for fatty acyl transfer
D Wu, L Govindasamy, W Lian, Y Gu, T Kukar, M Agbandje-McKenna, ...
Journal of Biological Chemistry 278 (15), 13159-13165, 2003
Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)
JD Shi, T Kukar, CY Wang, QZ Li, PE Cruz, A Davoodi-Semiromi, P Yang, ...
Journal of Biological Chemistry 276 (20), 17474-17478, 2001
Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
J Root, P Merino, A Nuckols, M Johnson, T Kukar
Neurobiology of disease 154, 105360, 2021
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
C Verbeeck, Q Deng, M DeJesus-Hernandez, G Taylor, C Ceballos-Diaz, ...
Molecular neurodegeneration 7 (1), 1-13, 2012
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis …
TL Kukar, TB Ladd, P Robertson, SA Pintchovski, B Moore, MA Bann, ...
Journal of Biological Chemistry 286 (46), 39804-39812, 2011
Possible mechanisms of action of NSAIDs and related compounds that modulate γ-secretase cleavage
T Kukar, TE Golde
Current topics in medicinal chemistry 8 (1), 47-53, 2008
Short Aβ peptides attenuate Aβ42 toxicity in vivo
BD Moore, J Martin, L de Mena, J Sanchez, PE Cruz, C Ceballos-Diaz, ...
Journal of Experimental Medicine 215 (1), 283-301, 2018
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase
AC Nyborg, TB Ladd, K Jansen, T Kukar, TE Golde
The FASEB journal 20 (10), 1671-1679, 2006
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