Matthew Guenther
Matthew Guenther
Syros Pharmaceuticals
Verified email at
Cited by
Cited by
Core transcriptional regulatory circuitry in human embryonic stem cells
LA Boyer, TI Lee, MF Cole, SE Johnstone, SS Levine, JP Zucker, ...
cell 122 (6), 947-956, 2005
Control of developmental regulators by Polycomb in human embryonic stem cells
TI Lee, RG Jenner, LA Boyer, MG Guenther, SS Levine, RM Kumar, ...
Cell 125 (2), 301-313, 2006
A chromatin landmark and transcription initiation at most promoters in human cells
MG Guenther, SS Levine, LA Boyer, R Jaenisch, RA Young
Cell 130 (1), 77-88, 2007
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
CJ Phiel, F Zhang, EY Huang, MG Guenther, MA Lazar, PS Klein
Journal of Biological Chemistry 276 (39), 36734-36741, 2001
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
A Marson, SS Levine, MF Cole, GM Frampton, T Brambrink, S Johnstone, ...
cell 134 (3), 521-533, 2008
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
W Fischle, F Dequiedt, MJ Hendzel, MG Guenther, MA Lazar, W Voelter, ...
Molecular cell 9 (1), 45-57, 2002
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
MG Guenther, ORR Barak, MA Lazar
Molecular and cellular biology, 2001
Master transcription factors determine cell-type-specific responses to TGF-β signaling
AC Mullen, DA Orlando, JJ Newman, J Lovén, RM Kumar, S Bilodeau, ...
Cell 147 (3), 565-576, 2011
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
MG Guenther, WS Lane, W Fischle, E Verdin, MA Lazar, R Shiekhattar
Genes & development 14 (9), 1048-1057, 2000
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
MG Guenther, GM Frampton, F Soldner, D Hockemeyer, M Mitalipova, ...
Cell stem cell 7 (2), 249-257, 2010
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells
AA Sigova, AC Mullen, B Molinie, S Gupta, DA Orlando, MG Guenther, ...
Proceedings of the National Academy of Sciences 110 (8), 2876-2881, 2013
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome
DA Orlando, MW Chen, VE Brown, S Solanki, YJ Choi, ER Olson, CC Fritz, ...
Cell reports 9 (3), 1163-1170, 2014
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
CJ Lengner, AA Gimelbrant, JA Erwin, AW Cheng, MG Guenther, ...
Cell 141 (5), 872-883, 2010
Global and Hox-specific roles for the MLL1 methyltransferase
MG Guenther, RG Jenner, B Chevalier, T Nakamura, CM Croce, ...
Proceedings of the National Academy of Sciences 102 (24), 8603-8608, 2005
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
EY Huang, J Zhang, EA Miska, MG Guenther, T Kouzarides, MA Lazar
Genes & development 14 (1), 45-54, 2000
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
MG Guenther, LN Lawton, T Rozovskaia, GM Frampton, SS Levine, ...
Genes & development 22 (24), 3403-3408, 2008
Proteasomal regulation of nuclear receptor corepressor-mediated repression
J Zhang, MG Guenther, RW Carthew, MA Lazar
Genes & development 12 (12), 1775-1780, 1998
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
GD Kao, WG McKenna, MG Guenther, RJ Muschel, MA Lazar, TJ Yen
The Journal of cell biology 160 (7), 1017-1027, 2003
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
J Yu, Y Li, T Ishizuka, MG Guenther, MA Lazar
The EMBO journal, 2003
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy
ME Beaulieu, T Jauset, D Massó-Vallés, S Martínez-Martín, P Rahl, ...
Science translational medicine 11 (484), eaar5012, 2019
The system can't perform the operation now. Try again later.
Articles 1–20