| Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction C Yung-Chi, WH Prusoff Biochemical pharmacology 22 (23), 3099-3108, 1973 | 16001 | 1973 |
| Antisense oligonucleotides as therapeutic agents—is the bullet really magical? CA Stein, YC Cheng Science 261 (5124), 1004-1012, 1993 | 1815 | 1993 |
| Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells M Wigler, S Silverstein, LS Lee, A Pellicer, Y Cheng, R Axel Cell 11 (1), 223-232, 1977 | 1809 | 1977 |
| Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy'3'-thiacytidine and related analogues CYC Doong SI, Tsai CHJ, Schinazi RF, Liotta DC PNAS USA, 1991 | 767* | 1991 |
| Metabolism and mechanism of action of 5-fluorouracil WB Parker, YC Cheng Pharmacology & therapeutics 48 (3), 381-395, 1990 | 586 | 1990 |
| Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity RA Finch, MC Liu, SP Grill, WC Rose, R Loomis, KM Vasquez, YC Cheng, ... Biochemical pharmacology 59 (8), 983-991, 2000 | 458 | 2000 |
| The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity W Lam, S Bussom, F Guan, Z Jiang, W Zhang, EA Gullen, SH Liu, ... Science translational medicine 2 (45), 45ra59-45ra59, 2010 | 397 | 2010 |
| Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity CYC Chen, CH, Vazquez-Paduo M Mol Pharmacol, 1991 | 380 | 1991 |
| Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′, 3′-dideoxycytidine CH Chen, YC Cheng Journal of Biological Chemistry 264 (20), 11934-11937, 1989 | 380 | 1989 |
| Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2', 3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication. CN Chang, SL Doong, JH Zhou, JW Beach, LS Jeong, CK Chu, CH Tsai, ... Journal of Biological Chemistry 267 (20), 13938-13942, 1992 | 353 | 1992 |
| Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs. YC Cheng, GE Dutschman, KF Bastow, MG Sarngadharan, RY Ting Journal of Biological Chemistry 262 (5), 2187-2189, 1987 | 336 | 1987 |
| Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus CK Chu, T Ma, K Shanmuganathan, C Wang, Y Xiang, SB Pai, GQ Yao, ... Antimicrobial Agents and Chemotherapy 39 (4), 979-981, 1995 | 319 | 1995 |
| Biochemical pharmacology of (+)-and (-)-2', 3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents. CN Chang, V Skalski, JH Zhou, YC Cheng Journal of Biological Chemistry 267 (31), 22414-22420, 1992 | 317 | 1992 |
| Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology. WY Gao, FS Han, C Storm, W Egan, YC Cheng Molecular Pharmacology 41 (2), 223-229, 1992 | 316 | 1992 |
| Unique spectrum of activity of 9-[(1, 3-dihydroxy-2-propoxy) methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1. YC Cheng, ES Huang, JC Lin, EC Mar, JS Pagano, GE Dutschman, ... Proceedings of the National Academy of Sciences 80 (9), 2767-2770, 1983 | 316 | 1983 |
| Anti-AIDS agents, 2: inhibitory effect of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells G Nonaka, I Nishioka, M Nishizawa, T Yamagishi, Y Kashiwada, ... Journal of Natural Products 53 (3), 587-595, 1990 | 303 | 1990 |
| Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice JP Gratton, MI Lin, J Yu, ED Weiss, ZL Jiang, TA Fairchild, Y Iwakiri, ... Cancer cell 4 (1), 31-39, 2003 | 300 | 2003 |
| An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA KM Chou, YC Cheng Nature 415 (6872), 655-659, 2002 | 293 | 2002 |
| Cellular metabolism of 2', 3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro. MC Starnes, YC Cheng Journal of Biological Chemistry 262 (3), 988-991, 1987 | 293 | 1987 |
| Anti-AIDS agents, 10. Acacetin-7-o-β-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids CQ Hu, KE Chen, Q Shi, RE Kilkuskie, YC Cheng, KH Lee Journal of natural products 57 (1), 42-51, 1994 | 283 | 1994 |
