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Emily A. Chapman
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High sensitivity top–down proteomics captures single muscle cell heterogeneity in large proteoforms
JA Melby, KA Brown, ZR Gregorich, DS Roberts, EA Chapman, LE Ehlers, ...
Proceedings of the National Academy of Sciences 120 (19), e2222081120, 2023
262023
Defining the sarcomeric proteoform landscape in ischemic cardiomyopathy by top-down proteomics
EA Chapman, TJ Aballo, JA Melby, T Zhou, SJ Price, KJ Rossler, I Lei, ...
Journal of Proteome Research 22 (3), 931-941, 2023
132023
Top-down proteomics of myosin light chain isoforms define chamber-specific expression in the human heart
EF Bayne, KJ Rossler, ZR Gregorich, TJ Aballo, DS Roberts, ...
Journal of Molecular and Cellular Cardiology 181, 89-97, 2023
42023
Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics
EA Chapman, DS Roberts, TN Tiambeng, J Andrews, MD Wang, ...
Nature Communications 14 (1), 8400, 2023
12023
Native Top-Down Mass Spectrometry for Characterizing Sarcomeric Proteins Directly from Cardiac Tissue Lysate
EA Chapman, BH Li, B Krichel, HJ Chan, KM Buck, DS Roberts, Y Ge
Journal of the American Society for Mass Spectrometry, 2024
2024
Integrated Proteomics Identifies Troponin I Isoform Switch as a Regulator of a Sarcomere-Metabolism Axis During Cardiac Regeneration
TJ Aballo, J Bae, WG Paltzer, EA Chapman, RJ Salamon, MM Mann, Y Ge, ...
bioRxiv, 2023
2023
Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics
EA Chapman, DS Roberts, TN Tiambeng, J Andrews, MD Wang, ...
Research Square, 2023
2023
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