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Georg Werner
Georg Werner
Verified email at med.uni-muenchen.de
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Year
TREM 2 deficiency impairs chemotaxis and microglial responses to neuronal injury
F Mazaheri, N Snaidero, G Kleinberger, C Madore, A Daria, G Werner, ...
EMBO reports 18 (7), 1186-1198, 2017
3152017
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ...
EMBO molecular medicine 12 (4), e11227, 2020
1862020
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
X Xiang, G Werner, B Bohrmann, A Liesz, F Mazaheri, A Capell, ...
EMBO molecular medicine 8 (9), 992-1004, 2016
1662016
Opposite microglial activation stages upon loss of PGRN or TREM 2 result in reduced cerebral glucose metabolism
JK Götzl, M Brendel, G Werner, S Parhizkar, L Sebastian Monasor, ...
EMBO molecular medicine 11 (6), e9711, 2019
962019
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
JK Götzl, AV Colombo, K Fellerer, A Reifschneider, G Werner, S Tahirovic, ...
Molecular neurodegeneration 13, 1-16, 2018
772018
Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Y Nihei, K Mori, G Werner, T Arzberger, Q Zhou, B Khosravi, J Japtok, ...
Acta neuropathologica 139, 99-118, 2020
532020
The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons
P Lüningschrör, G Werner, S Stroobants, S Kakuta, B Dombert, D Sinske, ...
Cell Reports 30 (10), 3506-3519. e6, 2020
452020
Loss of TMEM 106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
G Werner, M Damme, M Schludi, J Gnörich, K Wind, K Fellerer, B Wefers, ...
EMBO reports 21 (10), e50241, 2020
392020
Depletion and activation of microglia impact metabolic connectivity of the mouse brain
J Gnörich, A Reifschneider, K Wind, A Zatcepin, ST Kunte, P Beumers, ...
Journal of Neuroinflammation 20 (1), 47, 2023
62023
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019; 11 (6): e9711
JK Gotzl, M Brendel, G Werner, S Parhizkar, L Sebastian Monasor, ...
4
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice
C Krammer, B Yang, S Reichl, S Besson‐Girard, H Ji, V Bolini, C Schulte, ...
The FASEB Journal 37 (3), e22752, 2023
32023
Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin
M Reich, MJ Simon, B Polke, G Werner, C Schrader, I Paris, S Robinson, ...
bioRxiv, 2023.07. 14.549089, 2023
12023
Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration
S Robinson, M Reich, MT Muehlhofer, K Buschmann, E Wauters, ...
bioRxiv, 2024.01. 16.575687, 2024
2024
Depletion and activation of microglia alter metabolic connectivity of the mouse brain
J Gnörich, A Reifschneider, K Wind, A Zatcepin, S Kunte, P Beumers, ...
Nuklearmedizin-NuclearMedicine 62 (02), L19, 2023
2023
Modulation des Progranulin-abhängigen FTLD-Risikos durch TMEM106B
G Werner
lmu, 2021
2021
Opposite microglial phenotypes upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
M Deussing, J Götzl, G Werner, L Sebastian, G Kleinberger, S Parhizkar, ...
Nuklearmedizin-NuclearMedicine 58 (02), P33, 2019
2019
Loss-of progranulin leads to a cell-autonomous lysosomal phenotype
G Werner, K Fellerer, CM Lang, C Haass, A Capell
Journal of Neurochemistry, 419-419, 2016
2016
Role of Trem2 in Neurodegeneration: A systems biology approach
F Mazaheri, G Kleinberger, A Daria, G Werner, S Tahirovic, D Truembach, ...
Journal of Neurochemistry, 411-411, 2016
2016
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