TREM 2 deficiency impairs chemotaxis and microglial responses to neuronal injury F Mazaheri, N Snaidero, G Kleinberger, C Madore, A Daria, G Werner, ... EMBO reports 18 (7), 1186-1198, 2017 | 315 | 2017 |
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ... EMBO molecular medicine 12 (4), e11227, 2020 | 186 | 2020 |
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance X Xiang, G Werner, B Bohrmann, A Liesz, F Mazaheri, A Capell, ... EMBO molecular medicine 8 (9), 992-1004, 2016 | 166 | 2016 |
Opposite microglial activation stages upon loss of PGRN or TREM 2 result in reduced cerebral glucose metabolism JK Götzl, M Brendel, G Werner, S Parhizkar, L Sebastian Monasor, ... EMBO molecular medicine 11 (6), e9711, 2019 | 96 | 2019 |
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice JK Götzl, AV Colombo, K Fellerer, A Reifschneider, G Werner, S Tahirovic, ... Molecular neurodegeneration 13, 1-16, 2018 | 77 | 2018 |
Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 Y Nihei, K Mori, G Werner, T Arzberger, Q Zhou, B Khosravi, J Japtok, ... Acta neuropathologica 139, 99-118, 2020 | 53 | 2020 |
The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons P Lüningschrör, G Werner, S Stroobants, S Kakuta, B Dombert, D Sinske, ... Cell Reports 30 (10), 3506-3519. e6, 2020 | 45 | 2020 |
Loss of TMEM 106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice G Werner, M Damme, M Schludi, J Gnörich, K Wind, K Fellerer, B Wefers, ... EMBO reports 21 (10), e50241, 2020 | 39 | 2020 |
Depletion and activation of microglia impact metabolic connectivity of the mouse brain J Gnörich, A Reifschneider, K Wind, A Zatcepin, ST Kunte, P Beumers, ... Journal of Neuroinflammation 20 (1), 47, 2023 | 6 | 2023 |
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019; 11 (6): e9711 JK Gotzl, M Brendel, G Werner, S Parhizkar, L Sebastian Monasor, ... | 4 | |
Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice C Krammer, B Yang, S Reichl, S Besson‐Girard, H Ji, V Bolini, C Schulte, ... The FASEB Journal 37 (3), e22752, 2023 | 3 | 2023 |
Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin M Reich, MJ Simon, B Polke, G Werner, C Schrader, I Paris, S Robinson, ... bioRxiv, 2023.07. 14.549089, 2023 | 1 | 2023 |
Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration S Robinson, M Reich, MT Muehlhofer, K Buschmann, E Wauters, ... bioRxiv, 2024.01. 16.575687, 2024 | | 2024 |
Depletion and activation of microglia alter metabolic connectivity of the mouse brain J Gnörich, A Reifschneider, K Wind, A Zatcepin, S Kunte, P Beumers, ... Nuklearmedizin-NuclearMedicine 62 (02), L19, 2023 | | 2023 |
Modulation des Progranulin-abhängigen FTLD-Risikos durch TMEM106B G Werner lmu, 2021 | | 2021 |
Opposite microglial phenotypes upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism M Deussing, J Götzl, G Werner, L Sebastian, G Kleinberger, S Parhizkar, ... Nuklearmedizin-NuclearMedicine 58 (02), P33, 2019 | | 2019 |
Loss-of progranulin leads to a cell-autonomous lysosomal phenotype G Werner, K Fellerer, CM Lang, C Haass, A Capell Journal of Neurochemistry, 419-419, 2016 | | 2016 |
Role of Trem2 in Neurodegeneration: A systems biology approach F Mazaheri, G Kleinberger, A Daria, G Werner, S Tahirovic, D Truembach, ... Journal of Neurochemistry, 411-411, 2016 | | 2016 |