| Engineering strategies for immunomodulatory cytokine therapies: challenges and clinical progress IS Pires, PT Hammond, DJ Irvine Advanced therapeutics 4 (8), 2100035, 2021 | 76 | 2021 |
| Human STING is a proton channel B Liu, RJ Carlson, IS Pires, M Gentili, E Feng, Q Hellier, MA Schwartz, ... Science 381 (6657), 508-514, 2023 | 72 | 2023 |
| Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity L Ma, A Hostetler, DM Morgan, L Maiorino, I Sulkaj, CA Whittaker, ... Cell 186 (15), 3148-3165. e20, 2023 | 72 | 2023 |
| Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm M Hugelshofer, RM Buzzi, CA Schaer, H Richter, K Akeret, ... The Journal of clinical investigation 129 (12), 5219-5235, 2019 | 72 | 2019 |
| Controlled polymerization and ultrafiltration increase the consistency of polymerized hemoglobin for use as an oxygen carrier DA Belcher, CT Cuddington, EL Martindale, IS Pires, AF Palmer Bioconjugate Chemistry 31 (3), 605-621, 2019 | 31 | 2019 |
| Anti‐inflammatory effects of haptoglobin on LPS‐stimulated macrophages: role of HMGB1 signaling and implications in chronic wound healing P Krzyszczyk, HJ Kang, S Kumar, Y Meng, MD O'Reggio, K Patel, IS Pires, ... Wound repair and regeneration 28 (4), 493-505, 2020 | 28 | 2020 |
| Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme CJ Munoz, IS Pires, JH Baek, PW Buehler, AF Palmer, P Cabrales American Journal of Physiology-Heart and Circulatory Physiology 318 (5 …, 2020 | 22 | 2020 |
| Selective protein purification via tangential flow filtration–Exploiting protein-protein complexes to enable size-based separations IS Pires, AF Palmer Journal of Membrane Science 618, 118712, 2021 | 21 | 2021 |
| Quantification of active apohemoglobin heme-binding sites via dicyanohemin incorporation IS Pires, DA Belcher, AF Palmer Biochemistry 56 (40), 5245-5259, 2017 | 21 | 2017 |
| Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors AE Barberio, SG Smith, IS Pires, S Iyer, F Reinhardt, MB Melo, H Suh, ... Bioengineering & Translational Medicine 8 (2), e10453, 2023 | 19 | 2023 |
| Novel manufacturing method for producing apohemoglobin and its biophysical properties IS Pires, DA Belcher, R Hickey, C Miller, AK Badu‐Tawiah, JH Baek, ... Biotechnology and Bioengineering 117 (1), 125-145, 2020 | 19 | 2020 |
| Tangential flow filtration of haptoglobin IS Pires, AF Palmer Biotechnology Progress 36 (5), e3010, 2020 | 14 | 2020 |
| Poly (ethylene glycol) surface-conjugated apohemoglobin as a synthetic heme scavenger IS Pires, C Savla, AF Palmer Biomacromolecules 21 (6), 2155-2164, 2020 | 14 | 2020 |
| Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross‐link density X Gu, C Bolden‐Rush, CT Cuddington, DA Belcher, C Savla, IS Pires, ... Biotechnology and bioengineering 117 (8), 2362-2376, 2020 | 11 | 2020 |
| Engineering therapeutics to detoxify hemoglobin, heme, and iron IS Pires, F Berthiaume, AF Palmer Annual Review of Biomedical Engineering 25 (1), 1-21, 2023 | 10 | 2023 |
| Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer S Kong, P Moharil, A Handly‐Santana, N Boehnke, R Panayiotou, ... Bioengineering & Translational Medicine 8 (2), e10429, 2023 | 8 | 2023 |
| Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin DA Belcher, C Munoz, IS Pires, AT Williams, P Cabrales, AF Palmer Blood Advances 4 (12), 2739-2750, 2020 | 8 | 2020 |
| Controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes IS Pires, K Ni, MB Melo, N Li, E Ben-Akiva, L Maiorino, J Dye, ... Chemical Engineering Journal 464, 142664, 2023 | 6 | 2023 |
| Purification and analysis of a protein cocktail capable of scavenging cell‐free hemoglobin, heme, and iron IS Pires, K Govender, CJ Munoz, AT Williams, QT O'Boyle, C Savla, ... Transfusion 61 (6), 1894-1907, 2021 | 6 | 2021 |
| Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme CJ Munoz, IS Pires, V Jani, S Gopal, AF Palmer, P Cabrales Biomedicine & Pharmacotherapy 156, 113911, 2022 | 5 | 2022 |
