Ivan S Pires
Ivan S Pires
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Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm
M Hugelshofer, RM Buzzi, CA Schaer, H Richter, K Akeret, ...
The Journal of clinical investigation 129 (12), 5219-5235, 2019
Engineering strategies for immunomodulatory cytokine therapies: challenges and clinical progress
IS Pires, PT Hammond, DJ Irvine
Advanced therapeutics 4 (8), 2100035, 2021
Human STING is a proton channel
B Liu, RJ Carlson, IS Pires, M Gentili, E Feng, Q Hellier, MA Schwartz, ...
Science 381 (6657), 508-514, 2023
Controlled polymerization and ultrafiltration increase the consistency of polymerized hemoglobin for use as an oxygen carrier
DA Belcher, CT Cuddington, EL Martindale, IS Pires, AF Palmer
Bioconjugate Chemistry 31 (3), 605-621, 2019
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
L Ma, A Hostetler, DM Morgan, L Maiorino, I Sulkaj, CA Whittaker, ...
Cell 186 (15), 3148-3165. e20, 2023
Quantification of active apohemoglobin heme-binding sites via dicyanohemin incorporation
IS Pires, DA Belcher, AF Palmer
Biochemistry 56 (40), 5245-5259, 2017
Anti‐inflammatory effects of haptoglobin on LPS‐stimulated macrophages: role of HMGB1 signaling and implications in chronic wound healing
P Krzyszczyk, HJ Kang, S Kumar, Y Meng, MD O'Reggio, K Patel, IS Pires, ...
Wound repair and regeneration 28 (4), 493-505, 2020
Selective protein purification via tangential flow filtrationíVExploiting protein-protein complexes to enable size-based separations
IS Pires, AF Palmer
Journal of Membrane Science 618, 118712, 2021
Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme
CJ Munoz, IS Pires, JH Baek, PW Buehler, AF Palmer, P Cabrales
American Journal of Physiology-Heart and Circulatory Physiology 318 (5 íK, 2020
Novel manufacturing method for producing apohemoglobin and its biophysical properties
IS Pires, DA Belcher, R Hickey, C Miller, AK Badu‐Tawiah, JH Baek, ...
Biotechnology and Bioengineering 117 (1), 125-145, 2020
Tangential flow filtration of haptoglobin
IS Pires, AF Palmer
Biotechnology Progress 36 (5), e3010, 2020
Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors
AE Barberio, SG Smith, IS Pires, S Iyer, F Reinhardt, MB Melo, H Suh, ...
Bioengineering & Translational Medicine 8 (2), e10453, 2023
Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross‐link density
X Gu, C Bolden‐Rush, CT Cuddington, DA Belcher, C Savla, IS Pires, ...
Biotechnology and bioengineering 117 (8), 2362-2376, 2020
Poly (ethylene glycol) surface-conjugated apohemoglobin as a synthetic heme scavenger
IS Pires, C Savla, AF Palmer
Biomacromolecules 21 (6), 2155-2164, 2020
Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin
DA Belcher, C Munoz, IS Pires, AT Williams, P Cabrales, AF Palmer
Blood advances 4 (12), 2739-2750, 2020
Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer
S Kong, P Moharil, A Handly‐Santana, N Boehnke, R Panayiotou, ...
Bioengineering & Translational Medicine 8 (2), e10429, 2023
Purification and analysis of a protein cocktail capable of scavenging cell‐free hemoglobin, heme, and iron
IS Pires, K Govender, CJ Munoz, AT Williams, QT O'Boyle, C Savla, ...
Transfusion 61 (6), 1894-1907, 2021
Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with ú]-thalassemia via scavenging of cell-free hemoglobin and heme
CJ Munoz, IS Pires, V Jani, S Gopal, AF Palmer, P Cabrales
Biomedicine & Pharmacotherapy 156, 113911, 2022
Enhanced Photodynamic Therapy using the Apohemoglobin-Haptoglobin Complex as a Carrier of Aluminum Phthalocyanine
IS Pires, QT O'Boyle, CJ Munoz, C Savla, P Cabrales, AF Palmer
ACS Applied Bio Materials, 2020
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron
IS Pires, F Berthiaume, AF Palmer
Annual Review of Biomedical Engineering 25, 1-21, 2023
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