| R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils Y Fan, RS Nirujogi, A Garrido, J Ruiz-Martínez, A Bergareche-Yarza, ... Acta Neuropathologica 142 (3), 475-494, 2021 | 49 | 2021 |
| DIMP 53‐1: a novel small‐molecule dual inhibitor of p53–MDM 2/X interactions with multifunctional p53‐dependent anticancer properties J Soares, M Espadinha, L Raimundo, H Ramos, AS Gomes, S Gomes, ... Molecular Oncology 11 (6), 612-627, 2017 | 47 | 2017 |
| New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma S Gomes, L Raimundo, J Soares, JB Loureiro, M Leao, H Ramos, ... Cancer letters 446, 90-102, 2019 | 44 | 2019 |
| Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule J Soares, L Raimundo, NAL Pereira, Â Monteiro, S Gomes, C Bessa, ... Oncotarget 7 (4), 4326, 2016 | 44 | 2016 |
| α-Mangostin and gambogic acid as potential inhibitors of the p53–MDM2 interaction revealed by a yeast approach M Leao, S Gomes, J Pedraza-Chaverri, N Machado, E Sousa, M Pinto, ... Journal of natural products 76 (4), 774-778, 2013 | 44 | 2013 |
| Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53–MDM2 interaction M Leão, J Soares, S Gomes, L Raimundo, H Ramos, C Bessa, G Queiroz, ... Life sciences 142, 60-65, 2015 | 36 | 2015 |
| Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold D Pereira, RT Lima, A Palmeira, H Seca, J Soares, S Gomes, L Raimundo, ... Arabian Journal of Chemistry 12 (8), 4150-4161, 2019 | 33 | 2019 |
| SLMP53-2 restores wild-type-like function to mutant p53 through Hsp70: promising activity in hepatocellular carcinoma S Gomes, B Bosco, JB Loureiro, H Ramos, L Raimundo, J Soares, ... Cancers 11 (8), 1151, 2019 | 24 | 2019 |
| Novel simplified yeast‐based assays of regulators of p53–MDMX interaction and p53 transcriptional activity M Leão, S Gomes, J Soares, C Bessa, C Maciel, Y Ciribilli, C Pereira, ... The FEBS Journal 280 (24), 6498-6507, 2013 | 20 | 2013 |
| Small molecules targeting mutant p53: A promising approach for cancer treatment EA Lopes, S Gomes, L Saraiva, MMM Santos Current Medicinal Chemistry 26 (41), 7323-7336, 2019 | 19 | 2019 |
| Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules M Leão, S Gomes, C Bessa, J Soares, L Raimundo, P Monti, G Fronza, ... Experimental cell research 330 (1), 164-177, 2015 | 18 | 2015 |
| p53 family interactions and yeast: together in anticancer therapy S Gomes, M Leao, L Raimundo, H Ramos, J Soares, L Saraiva Drug Discovery Today 21 (4), 616-624, 2016 | 17 | 2016 |
| SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations AS Gomes, H Ramos, S Gomes, JB Loureiro, J Soares, V Barcherini, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (1), 129440, 2020 | 16 | 2020 |
| Yeast as a chassis for developing functional assays to study human P53 P Monti, B Bosco, S Gomes, L Saraiva, G Fronza, A Inga JoVE (Journal of Visualized Experiments), e59071, 2019 | 16 | 2019 |
| Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease S Gomes, A Garrido, F Tonelli, D Obiang, E Tolosa, MJ Martí, ... npj Parkinson's Disease 9 (1), 52, 2023 | 5 | 2023 |
| Biological Effects of Saponin Fractions from Astragalus verrucosus in Tumor and Non-tumor Human cells MS Facioni, J Soares, B Adinolfi, S Gomes, L Raimundo, A Contini, ... Natural Product Communications 13 (9), 1934578X1801300903, 2018 | 5 | 2018 |
| Using yeast to uncover the regulation of protein kinase Cδ by ceramide C Bessa, C Pereira, M Leao, C Maciel, S Gomes, J Gonçalves, ... FEMS Yeast Research 13 (7), 700-705, 2013 | 4 | 2013 |
| Elevated urine BMPs-bis (Monoacylglycerol) Phosphates–in LRRK2 G2019S, R1441G/C and VPS35 D620N mutation carriers with and without Parkinson’s disease S Gomes, A Garrido, F Tonelli, D Obiang, E Tolosa, MJ Marti, ... medRxiv, 2022.08. 03.22278207, 2022 | 1 | 2022 |
| Correlating LRRK2 activation status in peripheral blood to urine BMPs in monogenic and idiopathic Parkinson’s disease S Gomes, A Garrido, F Tonelli, E Tolosa, M Marti, D Anderson, ... Movement Disorders 36 (Supplement 1), S333-S334, 2021 | | 2021 |
| Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity V Barcherini, S Gomes, M Espadinha, J Soares, L Raimundo, C Gomes, ... Universidade de Lisboa, 2019 | | 2019 |
