| The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis JM Lucas, C Heinlein, T Kim, SA Hernandez, MS Malik, LD True, ... Cancer discovery 4 (11), 1310-1325, 2014 | 492 | 2014 |
| Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates DV Santi, EL Schneider, R Reid, L Robinson, GW Ashley Proceedings of the National Academy of Sciences 109 (16), 6211-6216, 2012 | 118 | 2012 |
| IrAE–An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus D Sojka, O Hajdušek, J Dvořák, M Sajid, Z Franta, EL Schneider, CS Craik, ... International journal for parasitology 37 (7), 713-724, 2007 | 97 | 2007 |
| Structure of an Fab–protease complex reveals a highly specific non-canonical mechanism of inhibition CJ Farady, PF Egea, EL Schneider, MR Darragh, CS Craik Journal of molecular biology 380 (2), 351-360, 2008 | 77 | 2008 |
| A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target C He, GP Nora, EL Schneider, ID Kerr, E Hansell, K Hirata, D Gonzalez, ... Journal of Biological Chemistry 285 (24), 18516-18527, 2010 | 74 | 2010 |
| Macromolecular Prodrug That Provides the Irinotecan (CPT-11) Active-Metabolite SN-38 with Ultralong Half-Life, Low Cmax , and Low Glucuronide Formation DV Santi, EL Schneider, GW Ashley Journal of medicinal chemistry 57 (6), 2303-2314, 2014 | 71 | 2014 |
| SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni J Dvořák, ST Mashiyama, M Sajid, S Braschi, M Delcroix, EL Schneider, ... PLoS neglected tropical diseases 3 (6), e449, 2009 | 67 | 2009 |
| Heme Binding to the Histidine-Rich Protein II from Plasmodium falciparum EL Schneider, MA Marletta Biochemistry 44 (3), 979-986, 2005 | 67 | 2005 |
| IrCL1–The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus Z Franta, D Sojka, H Frantova, J Dvorak, M Horn, J Srba, P Talacko, ... International journal for parasitology 41 (12), 1253-1262, 2011 | 59 | 2011 |
| Tumor detection by imaging proteolytic activity MR Darragh, EL Schneider, J Lou, PJ Phojanakong, CJ Farady, JD Marks, ... Cancer research 70 (4), 1505-1512, 2010 | 58 | 2010 |
| Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides CE Cruz, AC Fogaça, ES Nakayasu, CB Angeli, R Belmonte, IC Almeida, ... Parasites & vectors 3, 1-15, 2010 | 57 | 2010 |
| A reverse binding motif that contributes to specific protease inhibition by antibodies EL Schneider, MS Lee, A Baharuddin, DH Goetz, CJ Farady, M Ward, ... Journal of molecular biology 415 (4), 699-715, 2012 | 56 | 2012 |
| Hydrogel drug delivery system using self-cleaving covalent linkers for once-a-week administration of exenatide EL Schneider, J Henise, R Reid, GW Ashley, DV Santi Bioconjugate chemistry 27 (5), 1210-1215, 2016 | 51 | 2016 |
| The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti K Dolečková, M Kašný, L Mikeš, J Cartwright, P Jedelský, EL Schneider, ... International journal for parasitology 39 (2), 201-211, 2009 | 46 | 2009 |
| Positional scanning synthetic combinatorial libraries for substrate profiling EL Schneider, CS Craik Proteases and Cancer: Methods and Protocols, 59-78, 2009 | 42 | 2009 |
| Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy CYH Choi, EL Schneider, JM Kim, IY Gluzman, DE Goldberg, JA Ellman, ... Chemistry & biology 9 (8), 881-889, 2002 | 34 | 2002 |
| Desulphurization of a fluid coke similar to the Athabasca oil sands coke ZM George, LG Schneider, EL Tollefson Fuel 57 (8), 497-501, 1978 | 27 | 1978 |
| Peg conjugates of exenatide DV Santi, EL Schneider, GW Ashley US Patent App. 14/352,644, 2014 | 23 | 2014 |
| A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist EL Schneider, BR Hearn, SJ Pfaff, R Reid, DG Parkes, N Vrang, ... ACS Chemical Biology 12 (8), 2107-2116, 2017 | 22 | 2017 |
| β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols EL Schneider, L Robinson, R Reid, GW Ashley, DV Santi Bioconjugate Chemistry 24 (12), 1990-1997, 2013 | 19 | 2013 |
Charles CraikProfessor of Pharmaceutical Chemistry, UCSFVerified email at ucsf.edu
