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Pablo Alcón Hernández
Pablo Alcón Hernández
MRC Laboratory of Molecular Biology
Verified email at mrc-lmb.cam.ac.uk
Title
Cited by
Cited by
Year
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
S Stella, P Alcón, G Montoya
Nature 546 (7659), 559-563, 2017
1922017
Conformational activation promotes CRISPR-Cas12a catalysis and resetting of the endonuclease activity
S Stella, P Mesa, J Thomsen, B Paul, P Alcón, SB Jensen, B Saligram, ...
Cell 175 (7), 1856-1871. e21, 2018
1792018
FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
P Alcón, S Shakeel, ZA Chen, J Rappsilber, KJ Patel, LA Passmore
Nature structural & molecular biology 27 (3), 240-248, 2020
902020
Structure of the Fanconi anaemia monoubiquitin ligase complex
S Shakeel, E Rajendra, P Alcón, F O’Reilly, DS Chorev, S Maslen, ...
Nature 575 (7781), 234-237, 2019
892019
Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing
S Stella, P Alcon, G Montoya
Nature Structural & Molecular Biology 24 (11), 882-892, 2017
702017
Molecular architecture of the Jumonji C family histone demethylase KDM5B
J Dorosz, LH Kristensen, NG Aduri, O Mirza, R Lousen, S Bucciarelli, ...
Scientific Reports 9 (1), 4019, 2019
212019
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
T Sijacki, P Alcón, ZA Chen, SH McLaughlin, S Shakeel, J Rappsilber, ...
Nature structural & molecular biology 29 (9), 881-890, 2022
132022
Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA
P Alcón, G Montoya, S Stella
Acta Crystallographica Section F: Structural Biology Communications 73 (7 …, 2017
82017
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders
JA Manso, T Marcos, V Ruiz-Martín, J Casas, P Alcón, M Sánchez Crespo, ...
Cellular and Molecular Life Sciences 79 (2), 131, 2022
72022
FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair
P Alcón, S Shakeel, KJ Patel, LA Passmore
BioRxiv, 858225, 2019
52019
Erratum: Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
S Stella, P Alcón, G Montoya
Nature 547 (7664), 476-476, 2017
22017
FANCD2-FANCI is a sliding DNA clamp that specifically recognizes ss/ds-DNA junctions
P Alcon, A Kaczmarczyk, T Sijacki, L Passmore, DS Rueda
Biophysical Journal 123 (3), 167a, 2024
2024
The histone binding capacity of SPT2 controls chromatin structure and function in Metazoa
G Saredi, FN Carelli, SGM Rolland, G Furlan, S Piquet, A Appert, ...
Nature Structural & Molecular Biology, 2024
2024
The histone chaperone SPT2 regulates chromatin structure and function in Metazoa
G Saredi, FN Carelli, SGM Rolland, G Furlan, S Piquet, A Appert, ...
Nature Structural & Molecular Biology, 1-13, 2024
2024
The histone chaperone activity of SPT2 controls chromatin structure and function in Metazoa
G Saredi, FN Carelli, G Furlan, S Rolland, S Piquet, A Appert, ...
bioRxiv, 2023.02. 16.528451, 2023
2023
Diffraction images of a crystal of the F-BAR domain of PSTPIP1 (Proline-serine-threonine phosphatase-interacting protein 1) bound to the C-terminal homology (CTH) segment of …
JA Manso, P Alcón, Y Bayón, A Alonso, JM Pereda
Zenodo, 2020
2020
Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease …
S Stella, P Mesa, J Thomsen, B Paul, P Alcon, SB Jensen, ME Moses, ...
Biophysical Journal 118 (3), 223a-224a, 2020
2020
Conformational activation promotes CRISPR-Cas12a catalysis and resetting of the endonuclease activity
N Hatzakis, S Stella, P Mesa, J Thomsen, B Paul, P Alcon, S Jensen, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019
2019
endonuclease in complex with guide RNA and target DNA
P Alcón, G Montoya, S Stella
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Articles 1–19