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Jennifer Bré
Jennifer Bré
Honorary Research Fellow, University of St Andrews
Verified email at st-andrews.ac.uk
Title
Cited by
Cited by
Year
Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031
A Sarr, J Bré, IH Um, TH Chan, P Mullen, DJ Harrison, PA Reynolds
Scientific Reports 9 (1), 7643, 2019
142019
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent
J Bré, AL Dickson, OJ Read, Y Zhang, FG McKissock, P Mullen, P Tang, ...
Cancer Chemotherapy and Pharmacology 91 (5), 401-412, 2023
112023
Heparanase-1 is upregulated by hepatitis C virus and favors its replication
C Gallard, N Lebsir, H Khursheed, E Reungoat, ML Plissonnier, J Bré, ...
Journal of hepatology 77 (1), 29-41, 2022
112022
NUC-1031 overcomes resistance associated with gemcitabine in cancer patients
J Bré, A Sarr, P Mullen, IH Um, SP Blagden, PA Reynolds, DJ Harrison
Cancer Research 78 (13_Supplement), 1855-1855, 2018
22018
Defining the mode of action of cisplatin combined with a phosphoramidate modification of gemcitabine
D Patel, AL Dickson, GM Zickuhr, IH Um, OJ Read, CM Czekster, P Mullen, ...
2024
A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death
oliver read, mustafa Elshani, J Bre, P Mullen, david j harrison, ying zhang
bioRxiv, 2024.10. 09.617410, 2024
2024
NUC-3373 is a potent TS inhibitor and induces DNA damage in NSCLC cancer cells regardless of histological subtype
B Kaghazchi, AL Dickson, G Zickuhr, DJ Harrison, J Bré
European Journal of Cancer 174, S66, 2022
2022
NUC-3373 induces DAMPs release from NSCLC cells potentiating a favourable immunogenic microenvironment
B Kaghazchi, IH Um, J Bré, DJ Harrison, OJ Read
European Journal of Cancer 174, S46, 2022
2022
NUC-3373 targets the DNA-directed pathway more effectively than 5-FU
J Bré, AL Dickson, OJ Read, Y Zhang, CM Czekster, DJ Harrison
Cancer Research 82 (12_Supplement), 1835-1835, 2022
2022
NUC-3373 potentiates immune-mediated cytotoxicity of CRC cells
OJ Read, J Bré, DJ Harrison
Cancer Research 82 (12_Supplement), 1113-1113, 2022
2022
Abstract P025: NUC-3373 is a more potent inhibitor of thymidylate synthase than 5-FU and reduces generation of toxic metabolites
J Bré, AL Dickson, OJ Read, Y Zhang, P Mullen, CM Czekster, ...
Molecular Cancer Therapeutics 20 (12_Supplement), P025-P025, 2021
2021
NUC-3373 induced DAMPs release in CRC cells promotes natural killer cell activation
OJ Read, DJ Harrison, J Bré
Cancer Research 81 (13_Supplement), 1655-1655, 2021
2021
NUC-1031 causes incorporation of fluorinated deoxycytidine into DNA, inducing persistent damage in biliary tract cancer cells
D Patel, AL Dickson, OJ Read, CM Czekster, EA Ghazaly, DJ Harrison, ...
Cancer Research 81 (13_Supplement), 1003-1003, 2021
2021
NUC-1031 causes release of DAMPs and upregulates PD-L1 expression in lung cancer cells
J Bré, OJ Read, DJ Harrison
Cancer Research 80 (16_Supplement), 1840-1840, 2020
2020
Exploration of the pharmacodynamic profile of Acelarin, a novel ProTide drug, in an in vitro model of ovarian cancer
J Bré
University of St Andrews, 2019
2019
Anti-cancer activity in patients with advanced ovarian and biliary tract cancers treated with NUC-1031 and platinum agents
SP Blagden, J Bré, P Mullen, C Gnanaranjan, EA Ghazaly, ...
Journal of Clinical Oncology 37 (15), 2019
2019
Genome-scale CRISPR/Cas9 screen identifies factors required for sensitivity to pyrimidine nucleoside analogs
A Sarr, J Bré, P Mullen, S Blagden, IH Um, DJ Harrison, PA Reynolds
Cancer Research 78 (13_Supplement), 572-572, 2018
2018
Supplementary information Heparanase is upregulated by HCV and favors its replication
C Gallard, N Lebsir, H Khursheed, E Reungoat, ML Plissonnier, J Bré, ...
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