| Inhibition and inactivation of human CYP2J2: implications in cardiac pathophysiology and opportunities in cancer therapy A Karkhanis, Y Hong, ECY Chan Biochemical Pharmacology 135, 12-21, 2017 | 54 | 2017 |
| Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites A Karkhanis, HY Lam, G Venkatesan, SK Koh, CLL Chai, L Zhou, Y Hong, ... Biochemical Pharmacology 107, 67-80, 2016 | 43 | 2016 |
| Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts AV Karkhanis, G Venkatesan, R Kambayashi, JWH Leow, MQ Han, ... Acta Pharmaceutica Sinica B 12 (10), 3905-3923, 2022 | 16 | 2022 |
| Dronedarone-induced cardiac mitochondrial dysfunction and its mitigation by epoxyeicosatrienoic acids A Karkhanis, JWH Leow, T Hagen, ECY Chan Toxicological Sciences 163 (1), 79-91, 2018 | 16 | 2018 |
| Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids A Karkhanis, NDT Tram, ECY Chan Biochemical Pharmacology 146, 188-198, 2017 | 14 | 2017 |
| Synthesis and assessment of non-allergenic aromatic amine hair dyes as efficient alternatives to paraphenylenediamine G Venkatesan, Y Dancik, YR Neupane, AV Karkhanis, P Bigliardi, ... ACS Sustainable Chemistry & Engineering 10 (2), 838-849, 2022 | 6 | 2022 |
| Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1) G Venkatesan, ZC Lim, AV Karkhanis, YR Neupane, Y Dancik, C Huang, ... Archives of Toxicology, 1-13, 2022 | 3 | 2022 |
| CYP2J2 inhibition: the arcane mechanism of dronedarone‐induced proarrhythmia ECYY Chan, A Karkhanis, A Mehta, W Shim The FASEB Journal 32, 833.9-833.9, 2018 | 3 | 2018 |
| Preliminary discovery of novel markers for human cell line activation test (h-CLAT) AV Karkhanis, ECY Chan, EC Ren Toxicology in Vitro 74, 105154, 2021 | 2 | 2021 |
| Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin U Ayyangar, A Karkhanis, H Tay, AFB Afandi, O Bhattacharjee, L Ks, ... The EMBO Journal, 1-22, 2024 | 1 | 2024 |
| 1476 Monitoring biomarkers of diabetic foot ulcers: Discovery proteomics from a prospective longitudinal study in an Asian population S Lee, AFB Afandi, H Tay, R Navasankari, A Karkhanis, JC Chan, Z Upton, ... Journal of Investigative Dermatology 143 (5), S253, 2023 | | 2023 |
| Cardiac therapeutic CYE Chan, AV Karkhanis, G Venkatesan US Patent App. 17/625,421, 2022 | | 2022 |
| Epidermis Derived Lactate Promotes Sterile Inflammation by Inducing Metabolic Rewiring in Macrophages U Ayyangar, A Karkhanis, H Tay, AFB Afandi, O Bhattacharjee, LS Han, ... bioRxiv, 2022.07. 29.501937, 2022 | | 2022 |
| DELINEATING THE MECHANISMS OF CARDIAC ADVERSE EFFECTS OF DRONEDARONE: A ROLE OF CYP2J2 KA VIDYADHAR | | 2017 |
| Dronedarone inhibits CYP2J3 activity in H9c2 cardiomyocytes without mitochondrial toxicity AV Karkhanis, JWH Leow, YZ Khow, T Ng, WW Teng, ECY Chan Drug Metabolism and Pharmacokinetics 1 (32), S72, 2017 | | 2017 |
| Inhibition and inactivation of human CYP2J2 A Karkhanis, Y Hong, ECY Chan | | |
Eric Chun Yong ChanProfessor (Department of Pharmacy, Faculty of Science), National University of SingaporeVerified email at nus.edu.sg
