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Alexander Sorets
Alexander Sorets
Verified email at Vanderbilt.Edu
Title
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Year
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
H Kim, K Leng, J Park, AG Sorets, S Kim, A Shostak, RJ Embalabala, ...
Nature communications 13 (1), 6581, 2022
512022
Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice
S Hana, M Peterson, H McLaughlin, E Marshall, AJ Fabian, O McKissick, ...
Gene therapy 28 (10), 646-658, 2021
362021
A microengineered Brain-Chip to model neuroinflammation in humans
I Pediaditakis, KR Kodella, DV Manatakis, CY Le, S Barthakur, A Sorets, ...
Iscience 25 (8), 2022
212022
Caveolae-mediated transport at the injured blood–brain barrier as an underexplored pathway for central nervous system drug delivery
AG Sorets, JC Rosch, CL Duvall, ES Lippmann
Current opinion in chemical engineering 30, 86-95, 2020
112020
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
SS Patel, EN Hoogenboezem, F Yu, CR DeJulius, RB Fletcher, AG Sorets, ...
Biomaterials 297, 122098, 2023
92023
Albumin-binding aptamer chimeras for improved siRNA bioavailability
JC Rosch, EN Hoogenboezem, AG Sorets, CL Duvall, ES Lippmann
Cellular and Molecular Bioengineering 15 (2), 161-173, 2022
82022
Albumin-binding RNAi conjugate for carrier free treatment of arthritis
JM Colazo, EN Hoogenboezem, MC Keech, N Francini, V Shah, F Yu, ...
bioRxiv, 2023.05. 31.542971, 2023
62023
Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system
A Sorets, K Schwensen, N Francini, A Kjar, A Abdulrahman, A Shostak, ...
bioRxiv, 2024.06. 09.598079, 2024
2024
IQGAP2 regulates blood-brain barrier immune dynamics
KA Katdare, A Kjar, NM O’Brown, EH Neal, AG Sorets, A Shostak, ...
bioRxiv, 2023
2023
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Articles 1–9