The ‘Digital Twin’to enable the vision of precision cardiology J Corral-Acero, F Margara, M Marciniak, C Rodero, F Loncaric, Y Feng, ... European heart journal 41 (48), 4556-4564, 2020 | 449 | 2020 |
In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment F Margara, ZJ Wang, F Levrero-Florencio, A Santiago, M Vázquez, ... Progress in biophysics and molecular biology 159, 58-74, 2021 | 65 | 2021 |
Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers F Levrero-Florencio, F Margara, E Zacur, A Bueno-Orovio, ZJ Wang, ... Computer methods in applied mechanics and engineering 361, 112762, 2020 | 59 | 2020 |
CalTrack: high-throughput automated calcium transient analysis in cardiomyocytes Y Psaras, F Margara, M Cicconet, AJ Sparrow, GG Repetti, M Schmid, ... Circulation research 129 (2), 326-341, 2021 | 40 | 2021 |
Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction ZJ Wang, A Santiago, X Zhou, L Wang, F Margara, F Levrero-Florencio, ... EP Europace 23 (Supplement_1), i143-i152, 2021 | 26 | 2021 |
Pharmacological management of hypertrophic cardiomyopathy: from bench to bedside C Palandri, L Santini, A Argirò, F Margara, R Doste, A Bueno-Orovio, ... Drugs 82 (8), 889-912, 2022 | 25 | 2022 |
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy F Margara, Y Psaras, ZJ Wang, M Schmid, R Doste, AC Garfinkel, ... Scientific reports 12 (1), 22501, 2022 | 15 | 2022 |
Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM JM Pioner, G Vitale, S Steczina, M Langione, F Margara, L Santini, ... Circulation research 132 (5), 628-644, 2023 | 8 | 2023 |
Mavacamten efficacy in mutation-specific hypertrophic cardiomyopathy: an in silico approach to inform precision medicine F Margara, B Rodriguez, CN Toepfer, A Bueno-Orovio 2021 Computing in Cardiology (CinC) 48, 1-4, 2021 | 4 | 2021 |
Human-based computational investigations into cardiac electromechanical alterations caused by drugs and hypertrophic cardiomyopathy F Margara University of Oxford, 2021 | 3 | 2021 |
Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy F Margara, Y Psaras, ZJ Wang, M Schmid, R Doste, A Garfinkel, ... bioRxiv, 2022.06. 08.495324, 2022 | 2 | 2022 |
Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants. C Toepfer, Y Psaras, F Margara, M Schmid, V Steeples, JD Marsiglia, ... Circulation Research 129 (Suppl_1), A402-A402, 2021 | 2 | 2021 |
Modelling and in silico simulation of human induced pluripotent stem cell derived cardiomyocyte electro-mechanical properties M Folkmanaite, X Zhou, F Margara, M Zaccolo, B Rodriguez Cardiovascular Research 118 (Supplement_1), cvac066. 010, 2022 | 1 | 2022 |
In silico identification of the key ionic currents modulating human pluripotent stem cell-derived cardiomyocytes towards an adult phenotype LL Riebel, E Passini, F Margara, M Paci, J Biasetti, B Rodriguez 2021 Computing in Cardiology (CinC) 48, 1-4, 2021 | 1 | 2021 |
Computational investigation of drug-induced effects on human cardiac electro-mechanics E Passini, F Margara, B Rodriguez EP Europace 23 (Supplement_3), euab116. 513, 2021 | 1 | 2021 |
Human ventricular modelling and simulation of drug action on electrophysiology and contraction F Margara, ZJ Wang, A Bueno-Orovio, B Rodriguez 2020 computing in cardiology, 1-4, 2020 | 1 | 2020 |
A Human-Based Computational Investigation Into Sarcomeric and Ionic Remodelling in Hypertrophic Cardiomyopathy A Lipov, F Margara, X Zhou, B Rodriguez, A Bueno-Orovio 2022 Computing in Cardiology (CinC) 498, 1-4, 2022 | | 2022 |
A translationally-relevant computational approach for the assessment of cardiac safety and efficacy of myosin modulators F Margara, B Rodriguez, CN Toepfer, A Bueno-Orovio JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 117, 2022 | | 2022 |
Contraction and electrophysiological abnormalities in myofilament mutation-positive and mutation-negative human HCM myocardium JM Pioner, G Vitale, L Santini, C Palandri, A Bueno-Orovio, F Margara, ... Biophysical Journal 121 (3), 435a-436a, 2022 | | 2022 |
In Silico Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Electro-Mechanical Modelling and Simulation M Folkmanaite, X Zhou, F Margara, M Zaccolo, B Rodriguez 2021 Computing in Cardiology (CinC) 48, 1-4, 2021 | | 2021 |