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Francesca Margara
Francesca Margara
Post-Doctoral Research Associate, University of Oxford
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The ‘Digital Twin’to enable the vision of precision cardiology
J Corral-Acero, F Margara, M Marciniak, C Rodero, F Loncaric, Y Feng, ...
European heart journal 41 (48), 4556-4564, 2020
4492020
In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment
F Margara, ZJ Wang, F Levrero-Florencio, A Santiago, M Vázquez, ...
Progress in biophysics and molecular biology 159, 58-74, 2021
652021
Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers
F Levrero-Florencio, F Margara, E Zacur, A Bueno-Orovio, ZJ Wang, ...
Computer methods in applied mechanics and engineering 361, 112762, 2020
592020
CalTrack: high-throughput automated calcium transient analysis in cardiomyocytes
Y Psaras, F Margara, M Cicconet, AJ Sparrow, GG Repetti, M Schmid, ...
Circulation research 129 (2), 326-341, 2021
402021
Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction
ZJ Wang, A Santiago, X Zhou, L Wang, F Margara, F Levrero-Florencio, ...
EP Europace 23 (Supplement_1), i143-i152, 2021
262021
Pharmacological management of hypertrophic cardiomyopathy: from bench to bedside
C Palandri, L Santini, A Argirò, F Margara, R Doste, A Bueno-Orovio, ...
Drugs 82 (8), 889-912, 2022
252022
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
F Margara, Y Psaras, ZJ Wang, M Schmid, R Doste, AC Garfinkel, ...
Scientific reports 12 (1), 22501, 2022
152022
Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM
JM Pioner, G Vitale, S Steczina, M Langione, F Margara, L Santini, ...
Circulation research 132 (5), 628-644, 2023
82023
Mavacamten efficacy in mutation-specific hypertrophic cardiomyopathy: an in silico approach to inform precision medicine
F Margara, B Rodriguez, CN Toepfer, A Bueno-Orovio
2021 Computing in Cardiology (CinC) 48, 1-4, 2021
42021
Human-based computational investigations into cardiac electromechanical alterations caused by drugs and hypertrophic cardiomyopathy
F Margara
University of Oxford, 2021
32021
Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy
F Margara, Y Psaras, ZJ Wang, M Schmid, R Doste, A Garfinkel, ...
bioRxiv, 2022.06. 08.495324, 2022
22022
Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants.
C Toepfer, Y Psaras, F Margara, M Schmid, V Steeples, JD Marsiglia, ...
Circulation Research 129 (Suppl_1), A402-A402, 2021
22021
Modelling and in silico simulation of human induced pluripotent stem cell derived cardiomyocyte electro-mechanical properties
M Folkmanaite, X Zhou, F Margara, M Zaccolo, B Rodriguez
Cardiovascular Research 118 (Supplement_1), cvac066. 010, 2022
12022
In silico identification of the key ionic currents modulating human pluripotent stem cell-derived cardiomyocytes towards an adult phenotype
LL Riebel, E Passini, F Margara, M Paci, J Biasetti, B Rodriguez
2021 Computing in Cardiology (CinC) 48, 1-4, 2021
12021
Computational investigation of drug-induced effects on human cardiac electro-mechanics
E Passini, F Margara, B Rodriguez
EP Europace 23 (Supplement_3), euab116. 513, 2021
12021
Human ventricular modelling and simulation of drug action on electrophysiology and contraction
F Margara, ZJ Wang, A Bueno-Orovio, B Rodriguez
2020 computing in cardiology, 1-4, 2020
12020
A Human-Based Computational Investigation Into Sarcomeric and Ionic Remodelling in Hypertrophic Cardiomyopathy
A Lipov, F Margara, X Zhou, B Rodriguez, A Bueno-Orovio
2022 Computing in Cardiology (CinC) 498, 1-4, 2022
2022
A translationally-relevant computational approach for the assessment of cardiac safety and efficacy of myosin modulators
F Margara, B Rodriguez, CN Toepfer, A Bueno-Orovio
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 117, 2022
2022
Contraction and electrophysiological abnormalities in myofilament mutation-positive and mutation-negative human HCM myocardium
JM Pioner, G Vitale, L Santini, C Palandri, A Bueno-Orovio, F Margara, ...
Biophysical Journal 121 (3), 435a-436a, 2022
2022
In Silico Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Electro-Mechanical Modelling and Simulation
M Folkmanaite, X Zhou, F Margara, M Zaccolo, B Rodriguez
2021 Computing in Cardiology (CinC) 48, 1-4, 2021
2021
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