Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza TR Abbott, G Dhamdhere, Y Liu, X Lin, L Goudy, L Zeng, A Chemparathy, ... Cell 181 (4), 865-876. e12, 2020 | 479 | 2020 |
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing X Xu, A Chemparathy, L Zeng, HR Kempton, S Shang, M Nakamura, ... Molecular cell 81 (20), 4333-4345. e4, 2021 | 221 | 2021 |
Nested epistasis enhancer networks for robust genome regulation X Lin, Y Liu, S Liu, X Zhu, L Wu, Y Zhu, D Zhao, X Xu, A Chemparathy, ... Science 377 (6610), 1077-1085, 2022 | 53 | 2022 |
Multiplexed genome regulation in vivo with hyper-efficient Cas12a LY Guo, J Bian, AE Davis, P Liu, HR Kempton, X Zhang, A Chemparathy, ... Nature cell biology 24 (4), 590-600, 2022 | 42 | 2022 |
Uncovering patterns of atomic interactions in static and dynamic structures of proteins AJ Venkatakrishnan, R Fonseca, AK Ma, SA Hollingsworth, ... BioRxiv, 840694, 2019 | 33 | 2019 |
A comprehensive analysis and resource to use CRISPR-Cas13 for broad-spectrum targeting of RNA viruses X Lin, Y Liu, A Chemparathy, T Pande, M La Russa, LS Qi Cell Reports Medicine 2 (4), 100245, 2021 | 30 | 2021 |
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro L Zeng, Y Liu, XH Nguyenla, TR Abbott, M Han, Y Zhu, A Chemparathy, ... Nature communications 13 (1), 2766, 2022 | 25 | 2022 |
Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes JM Paggi, JA Belk, SA Hollingsworth, N Villanueva, AS Powers, MJ Clark, ... Proceedings of the National Academy of Sciences 118 (51), e2112621118, 2021 | 23 | 2021 |
Computational methods for analysis of large-scale CRISPR screens X Lin, A Chemparathy, M La Russa, T Daley, LS Qi Annual Review of Biomedical Data Science 3, 137-162, 2020 | 8 | 2020 |
Development and implementation of a real-time bundle-adherence dashboard for central line-associated bloodstream infections A Chemparathy, MG Seneviratne, A Ward, S Mirchandani, R Li, R Mathew, ... Pediatric Quality & Safety 6 (4), e431, 2021 | 6 | 2021 |
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathology A Chemparathy, Y Le Guen, S Chen, EG Lee, L Leong, JE Gorzynski, ... Neuron 112 (7), 1110-1116. e5, 2024 | 5 | 2024 |
Leveraging non-structural data to predict structures of protein–ligand complexes JM Paggi, JA Belk, SA Hollingsworth, N Villanueva, AS Powers, MJ Clark, ... bioRxiv, 2020.06. 01.128181, 2020 | 3 | 2020 |
A 3′UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated With Increased Risk for FTLD-TDP A Chemparathy, Y Le Guen, Y Zeng, J Gorzynski, TD Jensen, C Yang, ... Neurology: Genetics 10 (1), e200124, 2024 | 2 | 2024 |
A 3' UTR Deletion Is a Leading Candidate Causal Variant at the TMEM106B Locus Reducing Risk for FTLD-TDP. A Chemparathy, YL Guen, Y Zeng, J Gorzynski, T Jensen, N Kasireddy, ... Medrxiv: the Preprint Server for Health Sciences, 2023 | 2 | 2023 |
The Association Between Central Line-Associated Bloodstream Infection and Central Line Access A Ward, A Chemparathy, M Seneviratne, S Gaskari, R Mathew, M Wood, ... Critical Care Medicine 51 (6), 787-796, 2023 | 1 | 2023 |
Novel characterization of Alzheimer’s disease genetic loci using long‐read sequencing L Talozzi, A Chemparathy, TD Jensen, J Gorzynski, ME Belloy, YL Guen, ... Alzheimer's & Dementia 19, e082689, 2023 | | 2023 |
APOE loss‐of‐function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathology YL Guen, A Chemparathy, S Chen, L Leong, JJ Gorzynski, G Xue, ... Alzheimer's & Dementia 19, e082628, 2023 | | 2023 |
Multiplex CRISPR genome regulation in the retina L Guo, J Bian, AE Davis, P Liu, H Kempton, X Zhang, A Chemparathy, ... Investigative Ophthalmology & Visual Science 63 (7), 57–A0030-57–A0030, 2022 | | 2022 |
Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza (preprint) TR Abbott, G Dhamdhere, Y Liu, X Lin, LE Goudy, L Zeng, A Chemparathy, ... | | 2020 |