| Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes M Prabu-Jeyabalan, E Nalivaika, CA Schiffer Structure 10 (3), 369-381, 2002 | 408 | 2002 |
| Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor DLNG Surleraux, A Tahri, WG Verschueren, GME Pille, HA De Kock, ... Journal of medicinal chemistry 48 (6), 1813-1822, 2005 | 303 | 2005 |
| Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor NM King, M Prabu-Jeyabalan, EA Nalivaika, P Wigerinck, MP de Béthune, ... Journal of virology 78 (21), 12012-12021, 2004 | 298 | 2004 |
| Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ... Journal of virology 77 (8), 4836-4847, 2003 | 279 | 2003 |
| Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ... Journal of virology 77 (8), 4836-4847, 2003 | 279 | 2003 |
| Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance WRP Scott, CA Schiffer Structure 8 (12), 1259-1265, 2000 | 255 | 2000 |
| The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ... PLoS pathogens 8 (7), e1002832, 2012 | 228 | 2012 |
| How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease M Prabu-Jeyabalan, E Nalivaika, CA Schiffer Journal of molecular biology 301 (5), 1207-1220, 2000 | 213 | 2000 |
| Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding KP Romano, A Ali, WE Royer, CA Schiffer Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010 | 212 | 2010 |
| Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations F Muecksch, Y Weisblum, CO Barnes, F Schmidt, D Schaefer-Babajew, ... Immunity 54 (8), 1853-1868. e7, 2021 | 182 | 2021 |
| Combating susceptibility to drug resistance: lessons from HIV-1 protease NM King, M Prabu-Jeyabalan, EA Nalivaika, CA Schiffer Chemistry & biology 11 (10), 1333-1338, 2004 | 177 | 2004 |
| Molecular basis for drug resistance in HIV-1 protease A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ... Viruses 2 (11), 2509-2535, 2010 | 164 | 2010 |
| Viral protease inhibitors J Anderson, C Schiffer, SK Lee, R Swanstrom Antiviral strategies, 85-110, 2009 | 162 | 2009 |
| Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces SMD Shandilya, MNL Nalam, EA Nalivaika, PJ Gross, JC Valesano, ... Structure 18 (1), 28-38, 2010 | 154 | 2010 |
| Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A MA Carpenter, M Li, A Rathore, L Lackey, EK Law, AM Land, B Leonard, ... Journal of Biological Chemistry 287 (41), 34801-34808, 2012 | 148 | 2012 |
| Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease SC Pettit, GJ Henderson, CA Schiffer, R Swanstrom Journal of Virology 76 (20), 10226-10233, 2002 | 148 | 2002 |
| Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site CA Schiffer, IJ Clifton, VJ Davisson, DV Santi, RM Stroud Biochemistry 34 (50), 16279-16287, 1995 | 144 | 1995 |
| HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants MD Altman, A Ali, GSK Kumar Reddy, MNL Nalam, SG Anjum, H Cao, ... Journal of the American Chemical Society 130 (19), 6099-6113, 2008 | 141 | 2008 |
| PTEN enters the nucleus by diffusion F Liu, S Wagner, RB Campbell, JA Nickerson, CA Schiffer, AH Ross Journal of cellular biochemistry 96 (2), 221-234, 2005 | 138 | 2005 |
| Influenza virus drug resistance: a time-sampled population genetics perspective M Foll, YP Poh, N Renzette, A Ferrer-Admetlla, C Bank, H Shim, ... PLoS genetics 10 (2), e1004185, 2014 | 137 | 2014 |
Aysegul OzenNested TherapeuticsVerified email at nestedtx.com
