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Christopher Manzella
Christopher Manzella
University of Pennsylvania
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Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
C Manzella, M Singhal, WA Alrefai, S Saksena, PK Dudeja, RK Gill
Scientific reports 8 (1), 6103, 2018
822018
Serotonin transporter deficiency is associated with dysbiosis and changes in metabolic function of the mouse intestinal microbiome
M Singhal, BA Turturice, CR Manzella, R Ranjan, AA Metwally, J Theorell, ...
Scientific reports 9 (1), 2138, 2019
632019
Serum serotonin differentiates between disease activity states in Crohn’s patients
CR Manzella, D Jayawardena, W Pagani, Y Li, WA Alrefai, J Bauer, ...
Inflammatory Bowel Diseases 26 (10), 1607-1618, 2020
352020
Serotonin modulates AhR activation by interfering with CYP1A1-mediated clearance of AhR ligands
CR Manzella, M Ackerman, M Singhal, AL Ticho, J Ceh, WA Alrefai, ...
Cellular physiology and biochemistry: international journal of experimental …, 2020
302020
Infection with enteric pathogens Salmonella typhimurium and Citrobacter rodentium modulate TGF-beta/Smad signaling pathways in the intestine
YG Zhang, M Singhal, Z Lin, C Manzella, A Kumar, WA Alrefai, PK Dudeja, ...
Gut Microbes 9 (4), 326-337, 2018
212018
Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC)
M Singhal, C Manzella, V Soni, WA Alrefai, S Saksena, GA Hecht, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 312 (5 …, 2017
212017
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2, 3-Dioxygenase Axis
M Priyadarshini, G Navarro, DJ Reiman, A Sharma, K Xu, K Lednovich, ...
Gastroenterology 162 (6), 1675-1689. e11, 2022
172022
S-acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells
AL Ticho, P Malhotra, CR Manzella, PK Dudeja, S Saksena, RK Gill, ...
Journal of Biological Chemistry 295 (14), 4488-4497, 2020
142020
Serotonin transporter untranslated regions influence mRNA abundance and protein expression
C Manzella, M Singhal, M Ackerman, WA Alrefai, S Saksena, PK Dudeja, ...
Gene reports 18, 100513, 2020
82020
Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells
NW Holton, M Singhal, A Kumar, AL Ticho, CR Manzella, P Malhotra, ...
American Journal of Physiology-Cell Physiology 318 (6), C1294-C1304, 2020
52020
Sa1429 gene expression and miRNA profiling in ileal mucosa of SERT knock-out mouse using microarray approaches
CR Manzella, M Singhal, A Kumar, H Coffing, A Ticho, S Priyamvada, ...
Gastroenterology 150 (4), S313, 2016
12016
Serotonin is an Endogenous Regulator of the Aryl Hydrocarbon Receptor in the Intestine
C Manzella
University of Illinois at Chicago, 2021
2021
522–Serotonin Modulates Aryl Hydrocarbon Receptor (AHR) Activation in the Intestine by Interfering with Cyp1A1-Mediated Clearance of Ahr Ligands
CR Manzella, AL Ticho, M Singhal, S Saksena, WA Alrefai, PK Dudeja, ...
Gastroenterology 156 (6), S-105, 2019
2019
1093–A Novel Role of S-Acylation in the Modulation of Ileal Apical Sodium-Dependent Bile Acid Transporter (ASBT) Function
AL Ticho, P Malhotra, CR Manzella, PK Dudeja, S Saksena, RK Gill, ...
Gastroenterology 156 (6), S-233, 2019
2019
12 SEROTONIN MODULATES ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATION IN THE INTESTINE BY INTERFERING WITH CYP1A1-MEDIATED CLEARANCE OF AHR LIGANDS
C Manzella, A Ticho, M Ackerman, M Singhal, S Saksena, WA Alrefai, ...
Inflammatory Bowel Diseases 25 (Supplement_1), S59-S59, 2019
2019
181-Sert Deficiency Causes Dysbiosis and Changes in Metabolic Pathways in the Mouse Intestine
M Singhal, B Turturice, R Ranjan, CR Manzella, WA Alrefai, DL Perkins, ...
Gastroenterology 154 (6), S-46-S-47, 2018
2018
Serum Serotonin/Tryptophan Ratio Correlates with Inflammation in Crohn's Disease Patients
CR Manzella, J Bauer, B Jung, RK Gill
The FASEB Journal 32, 871.3-871.3, 2018
2018
The 5′‐UTR of Niemann‐Pick C1‐Like 1 Enhances Translation Efficiency
AL Ticho, P Malhotra, C Manzella, S Saksena, RK Gill, PK Dudeja, ...
The FASEB Journal 31, 1050.2-1050.2, 2017
2017
Intestinal Serotonin Transporter Untranslated Regions Influence MRNA Abundance and Protein Expression
CR Manzella, M Singhal, MT Ackerman, H Rashdan, S Saksena, ...
Gastroenterology 152 (5), S271-S272, 2017
2017
Caudal-Related Homeobox Transcription Factor 2 (CDX2) Regulates Serotonin Transporter Expression in Intestinal Epithelial Cells
M Singhal, I Chatterjee, CR Manzella, L Glofelty, M Verzi, S Saksena, ...
Gastroenterology 152 (5), S53, 2017
2017
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