| Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links CM Haney, MT Loch, WS Horne Chemical communications 47 (39), 10915-10917, 2011 | 94 | 2011 |
| Discovery of a selective and CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 with antidepressant and anxiolytic activity in rodents JL Engers, AL Rodriguez, LC Konkol, RD Morrison, AD Thompson, ... Journal of medicinal chemistry 58 (18), 7485-7500, 2015 | 70 | 2015 |
| Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 … CM Niswender, CK Jones, X Lin, M Bubser, A Thompson Gray, ... ACS chemical neuroscience 7 (9), 1201-1211, 2016 | 55 | 2016 |
| Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines M Abe, M Seto, RG Gogliotti, MT Loch, KA Bollinger, S Chang, ... ACS Medicinal Chemistry Letters 8 (10), 1110-1115, 2017 | 31 | 2017 |
| VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides CW Reed, KM McGowan, PK Spearing, BJ Stansley, HF Roenfanz, ... ACS Medicinal Chemistry Letters 8 (12), 1326-1330, 2017 | 21 | 2017 |
| Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease JD Panarese, DW Engers, YJ Wu, JJ Bronson, JE Macor, A Chun, ... ACS Medicinal Chemistry Letters 10 (3), 255-260, 2018 | 19 | 2018 |
| Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3 … SR Bollinger, DW Engers, JD Panarese, M West, JL Engers, MT Loch, ... Journal of Medicinal Chemistry 62 (1), 342-358, 2018 | 14 | 2018 |
| Challenges in the discovery and optimization of mGlu2/4 heterodimer positive allosteric modulators MG Fulton, MT Loch, CA Cuoco, AL Rodriguez, E Days, PN Vinson, ... Letters in drug design & discovery 16 (12), 1387-1394, 2019 | 7 | 2019 |
| Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4) RD Gogliotti, AL Blobaum, RM Morrison, JS Daniels, JM Salovich, ... Bioorganic & medicinal chemistry letters 26 (13), 2984-2987, 2016 | 5 | 2016 |
| Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1, 4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model CN Kent, MG Fulton, KJ Stillwell, JW Dickerson, MT Loch, AL Rodriguez, ... Bioorganic & Medicinal Chemistry Letters 37, 127838, 2021 | 4 | 2021 |
| Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity MG Fulton, MT Loch, AL Rodriguez, X Lin, JA Javitch, PJ Conn, ... Bioorganic & medicinal chemistry letters 30 (13), 127212, 2020 | 3 | 2020 |
| Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds Y Yamada, K Gilliland, Z Xiang, D Haymer, KE Crocker, MT Loch, ... Bioorganic & Medicinal Chemistry Letters 50, 128342, 2021 | 1 | 2021 |
| Bioorthogonal and dynamically reversible cross-linking strategies to promote peptide folding and stabilize protein-protein complexes CM Haney, M Loch, S Horne ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246, 2013 | | 2013 |
