Design, multigram synthesis, and in vitro and in vivo evaluation of propylamycin: A semisynthetic 4, 5-deoxystreptamine class aminoglycoside for the treatment of drug-resistant … T Matsushita, GC Sati, N Kondasinghe, MG Pirrone, T Kato, P Waduge, ... Journal of the American Chemical Society 141 (12), 5051-5061, 2019 | 57 | 2019 |
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity A Sonousi, JCK Quirke, P Waduge, T Janusic, M Gysin, K Haldimann, ... ChemMedChem 16 (2), 335-339, 2021 | 19 | 2021 |
Chemical probing for examining the structure of modified RNAs and ligand binding to RNA P Waduge, Y Sakakibara, CS Chow Methods 156, 110-120, 2019 | 18 | 2019 |
Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy C Dai, P Waduge, L Ji, C Huang, Y He, H Tian, E Zuniga-Sanchez, ... Cellular and Molecular Life Sciences 79 (1), 63, 2022 | 9 | 2022 |
Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization L Ji, P Waduge, L Hao, A Kaur, W Wan, Y Wu, H Tian, J Zhang, ... FASEB journal: official publication of the Federation of American Societies …, 2022 | 7 | 2022 |
Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites P Waduge, GC Sati, D Crich, CS Chow Bioorganic & medicinal chemistry 27 (22), 115121, 2019 | 6 | 2019 |
Comparative ligandomics implicates secretogranin III as a disease‐restricted angiogenic factor in laser‐induced choroidal neovascularization L Ji, P Waduge, W Wan, H Tian, J Li, J Zhang, R Chen, W Li The FEBS journal 289 (12), 3521-3534, 2022 | 5 | 2022 |
Profiling disease-selective drug targets: From proteomics to ligandomics P Waduge, H Tian, KA Webster, W Li Drug Discovery Today 28 (3), 103430, 2023 | 1 | 2023 |
Anti-Scg3 Gene Therapy to Treat Choroidal Neovascularization in Mice C Huang, L Ji, A Kaur, H Tian, P Waduge, KA Webster, W Li Biomedicines 11 (7), 1910, 2023 | | 2023 |
Secretogranin III Selectively Promotes Vascular Leakage in the Deep Vascular Plexus of Diabetic Retinopathy L Ji, P Waduge, Y Wu, C Huang, A Kaur, P Oliveira, H Tian, J Zhang, ... International Journal of Molecular Sciences 24 (13), 10531, 2023 | | 2023 |
Exploiting retinal endothelial heterogeneity for disease-targeted therapy of diabetic retinopathy P Waduge, L Ji, Y Wu, C Huang, A Kaur, P Oliveira, H Tian, J Zhang, ... Investigative Ophthalmology & Visual Science 64 (8), 997-997, 2023 | | 2023 |
Ligandomics: A new technology to globally map disease-selective angiogenic factors for ocular therapeutics W Li, P Waduge, H Tian, KA Webster Investigative Ophthalmology & Visual Science 64 (8), 1868-1868, 2023 | | 2023 |
Exploring the Binding of Aminoglycosides and Effect of Peptides on Functionally Important Regions of the Ribosome PMD Waduge Wayne State University, 2019 | | 2019 |