Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression D Yu, H Pendergraff, J Liu, HB Kordasiewicz, DW Cleveland, EE Swayze, ... Cell 150 (5), 895-908, 2012 | 327 | 2012 |
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2 J Liu, TS Tang, H Tu, O Nelson, E Herndon, DP Huynh, SM Pulst, ... Journal of Neuroscience 29 (29), 9148-9162, 2009 | 314 | 2009 |
Dopaminergic signaling and striatal neurodegeneration in Huntington's disease TS Tang, X Chen, J Liu, I Bezprozvanny Journal of Neuroscience 27 (30), 7899-7910, 2007 | 224 | 2007 |
Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism J Hu, J Liu, DR Corey Chemistry & biology 17 (11), 1183-1188, 2010 | 130 | 2010 |
Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing J Liu, J Hu, DR Corey Nucleic acids research 40 (3), 1240-1250, 2012 | 90 | 2012 |
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs J Hu, KT Gagnon, J Liu, JK Watts, J Syeda-Nawaz, CF Bennett, ... Walter de Gruyter 392 (4), 315-325, 2011 | 69 | 2011 |
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy J Liu, D Yu, Y Aiba, H Pendergraff, EE Swayze, WF Lima, J Hu, ... Nucleic acids research 41 (20), 9570-9583, 2013 | 45 | 2013 |
RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression J Liu, H Pendergraff, KJ Narayanannair, JG Lackey, S Kuchimanchi, ... Nucleic Acids Research 41 (18), 8788-8801, 2013 | 44 | 2013 |
Argonaute binding within 3′-untranslated regions poorly predicts gene repression Y Chu, A Kilikevicius, J Liu, KC Johnson, S Yokota, DR Corey Nucleic acids research 48 (13), 7439-7453, 2020 | 40 | 2020 |
Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway J Hu, J Liu, D Yu, Y Chu, DR Corey Nucleic acids research 40 (22), 11270-11280, 2012 | 39 | 2012 |
Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs J Hu, J Liu, D Yu, Y Aiba, S Lee, H Pendergraff, J Boubaker, JW Artates, ... nucleic acid therapeutics 24 (3), 199-209, 2014 | 36 | 2014 |
c9orf72 disease-related foci are each composed of one mutant expanded repeat RNA J Liu, J Hu, AT Ludlow, JT Pham, JW Shay, JD Rothstein, DR Corey Cell chemical biology 24 (2), 141-148, 2017 | 33 | 2017 |
Modulation of splicing by single-stranded silencing RNAs J Liu, J Hu, JA Hicks, TP Prakash, DR Corey nucleic acid therapeutics 25 (3), 113-120, 2015 | 32 | 2015 |
Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs J Hu, J Liu, KJ Narayanannair, JG Lackey, S Kuchimanchi, KG Rajeev, ... Biochemistry 53 (28), 4510-4518, 2014 | 31 | 2014 |
Engineering duplex RNAs for challenging targets: recognition of GGGGCC/CCCCGG repeats at the ALS/FTD C9orf72 locus J Hu, J Liu, L Li, KT Gagnon, DR Corey Chemistry & Biology 22 (11), 1505-1511, 2015 | 27 | 2015 |
Argonaute binding within human nuclear RNA and its impact on alternative splicing Y Chu, S Yokota, J Liu, A Kilikevicius, KC Johnson, DR Corey Rna 27 (9), 991-1003, 2021 | 26 | 2021 |
The requirement for GW182 scaffolding protein depends on whether argonaute is mediating translation, transcription, or splicing J Liu, Z Liu, DR Corey Biochemistry 57 (35), 5247-5256, 2018 | 23 | 2018 |
Oligonucleotide modulation of splicing J Liu, J Hu, DR Corey US Patent App. 14/009,745, 2014 | 23 | 2014 |
Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions Y Aiba, J Hu, J Liu, Q Xiang, C Martinez, DR Corey Biochemistry 52 (51), 9329-9338, 2013 | 20 | 2013 |
Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing ST Johnson, Y Chu, J Liu, DR Corey Rna 27 (9), 1004-1016, 2021 | 13 | 2021 |