| An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: support for a proposal to modify current regulatory guidelines FD Sistare, D Morton, C Alden, J Christensen, D Keller, SD Jonghe, ... Toxicologic pathology 39 (4), 716-744, 2011 | 146 | 2011 |
| Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database TM Monticello, TW Jones, DM Dambach, DM Potter, MW Bolt, M Liu, ... Toxicology and applied pharmacology 334, 100-109, 2017 | 137 | 2017 |
| FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology TB Knudsen, DA Keller, M Sander, EW Carney, NG Doerrer, DL Eaton, ... Toxicological Sciences 143 (2), 256-267, 2015 | 117 | 2015 |
| Identification and Characterization of Adverse Effects in 21st Century Toxicology DA Keller, DR Juberg, N Catlin, WH Farland, FG Hess, DC Wolf, ... Toxicological Sciences 126 (2), 291-297, 2012 | 106 | 2012 |
| Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry AR Baudy, MA Otieno, P Hewitt, J Gan, A Roth, D Keller, R Sura, ... Lab on a Chip 20 (2), 215-225, 2020 | 103 | 2020 |
| The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward J MacDonald, JE French, RJ Gerson, J Goodman, T Inoue, A Jacobs, ... Toxicological Sciences 77 (2), 188-194, 2004 | 89 | 2004 |
| Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective L Ewart, K Fabre, A Chakilam, Y Dragan, DB Duignan, J Eswaraka, J Gan, ... Experimental Biology and Medicine 242 (16), 1579-1585, 2017 | 81 | 2017 |
| Acylase I-Catalyzed Deacetylation of N-Acetyl-l-cysteine and S-Alkyl-N-acetyl-l-cysteines V Uttamsingh, DA Keller, MW Anders Chemical research in toxicology 11 (7), 800-809, 1998 | 75 | 1998 |
| Picomole analysis of glutathione, glutathione disulfide, glutathione S-sulfonate, and cysteine S-sulfonate by high-performance liquid chromatography DA Keller, DB Menzel Analytical biochemistry 151 (2), 418-423, 1985 | 64 | 1985 |
| Histochemical localization of formaldehyde dehydrogenase in the rat DA Keller, HA Heck, HW Randall, KT Morgan Toxicology and applied pharmacology 106 (2), 311-326, 1990 | 62 | 1990 |
| Effect of culture conditions on glutathione content in A549 cells GB Post, DA Keller, KA Connor, DB Menzel Biochemical and Biophysical Research Communications 114 (2), 737-742, 1983 | 60 | 1983 |
| Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems MF Peters, AL Choy, C Pin, DJ Leishman, A Moisan, L Ewart, ... Lab on a Chip 20 (7), 1177-1190, 2020 | 52 | 2020 |
| Neonatal mouse model: review of methods and results RM Mcclain, D Keller, D Casciano, P Fu, J Macdonald, J Popp, J Sagartz Toxicologic pathology 29 (1_suppl), 128-137, 2001 | 48 | 2001 |
| Fluoroacetate-mediated toxicity of fluorinated ethanes DA Keller, DC Roe, PH Lieder Toxicological Sciences 30 (2), 213-219, 1996 | 43 | 1996 |
| A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies JA Phillips, TSP Grandhi, M Davis, JC Gautier, N Hariparsad, D Keller, ... Lab on a Chip 20 (3), 468-476, 2020 | 36 | 2020 |
| Next‐generation DILI biomarkers: prioritization of biomarkers for qualification and best practices for biospecimen collection in drug development SE Roth, MI Avigan, D Bourdet, D Brott, R Church, A Dash, D Keller, ... Clinical Pharmacology & Therapeutics 107 (2), 333-346, 2020 | 33 | 2020 |
| Covalent Reactions in the Toxicity of SO2 and Sulfite DB Menzel, DOA Keller, KH Leung Biological Reactive Intermediates III: Mechanisms of Action in Animal Models …, 1986 | 28 | 1986 |
| Mechanistic studies on chloral toxicity: relationship to trichloroethylene carcinogenesis DA Keller, HA Heck Toxicology letters 42 (2), 183-191, 1988 | 26 | 1988 |
| Pharmacokinetics and Metabolism of Vinyl Fluoridein Vivoandin Vitro S Cantoreggi, DA Keller Toxicology and applied pharmacology 143 (1), 130-139, 1997 | 24 | 1997 |
| Effects of sulfite on glutathione S-sulfonate and the glutathione status of lung cells DA Keller, DB Menzel Chemico-biological interactions 70 (1-2), 145-156, 1989 | 23 | 1989 |
