| In vitro and in vivo isotope effects with hepatitis C protease inhibitors: enhanced plasma exposure of deuterated telaprevir versus telaprevir in rats F Maltais, YC Jung, M Chen, J Tanoury, RB Perni, N Mani, L Laitinen, ... Journal of medicinal chemistry 52 (24), 7993-8001, 2009 | 139 | 2009 |
| Discovery of VX-509 (decernotinib): a potent and selective Janus kinase 3 inhibitor for the treatment of autoimmune diseases LJ Farmer, MW Ledeboer, T Hoock, MJ Arnost, RS Bethiel, YL Bennani, ... Journal of medicinal chemistry 58 (18), 7195-7216, 2015 | 93 | 2015 |
| Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap H Gao, OL Materne, DL Howe, CL Brummel Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2007 | 60 | 2007 |
| Prospects for magnetic field communications and location using quantum sensors V Gerginov, FCS Da Silva, D Howe Review of Scientific Instruments 88 (12), 2017 | 54 | 2017 |
| Enzymatic synthesis of 3-deoxy-D-manno-octulosonate 8-phosphate, 3-deoxy-D-altro-octulosonate 8-phosphate, 3, 5-dideoxy-D-gluco (manno)-octulosonate 8-phosphate by 3-deoxy-D … GY Sheflyan, DL Howe, TL Wilson, RW Woodard Journal of the American Chemical Society 120 (43), 11027-11032, 1998 | 53 | 1998 |
| Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol M Chen, B LeDuc, S Kerr, D Howe, DA Williams Drug metabolism and disposition 38 (3), 368-375, 2010 | 52 | 2010 |
| Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase? J Wu, DL Howe, RW Woodard Journal of Biological Chemistry 278 (30), 27525-27531, 2003 | 49 | 2003 |
| Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide … DL Howe, AK Sundaram, J Wu, DL Gatti, RW Woodard Biochemistry 42 (17), 4843-4854, 2003 | 25 | 2003 |
| Identification and characterization of two chloramphenicol glucuronides from the in vitro glucuronidation of chloramphenicol in human liver microsomes M Chen, D Howe, B Leduc, S Kerr, DA Williams Xenobiotica 37 (9), 954-971, 2007 | 21 | 2007 |
| Probing the potential metal binding site in Escherichia coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (phenylalanine-sensitive) AK Sundaram, DL Howe, GY Sheflyan, RW Woodard FEBS letters 441 (2), 195-199, 1998 | 13 | 1998 |
| Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase DL Howe, HS Duewel, RW Woodard Journal of Biological Chemistry 275 (51), 40258-40265, 2000 | 11 | 2000 |
| Kinetic and Mutagenic Evidence for the Role of Histidine Residues in the Lycopersicon esculentum 1-Aminocyclopropane-1-carboxylic acid Oxidase MA Tayeh, DL Howe, HM Salleh, GY Sheflyan, JK Son, RW Woodard Journal of protein chemistry 18, 55-68, 1999 | 8 | 1999 |
| Deuterated aryl alkyl ethers synthesis via nucleophilic etherification of aryl alkyl ethers and thioethers with deuterated alcohols S Li, X Wang, XG Yang, GQ Yu, XQ Wang Synlett 30 (15), 1805-1809, 2019 | 1 | 2019 |
| Assessing compounds for liver distribution properties in a drug discovery setting L Laitinen, S Li, P McCarthy, C Zetterberg, LW Tung, A Rugg, H Tsao, ... DRUG METABOLISM REVIEWS 41, 111-112, 2009 | | 2009 |
| ENZYME CATALYSIS AND REGULATION-Thermotoga maritima 3-Deoxy-D-arabino-heptulosonate 7-Phosphate (DAHP) Synthase. THE ANCESTRAL EUBACTERIAL DAHP SYNTHASE? J Wu, DL Howe, RW Woodard Journal of Biological Chemistry 278 (30), 27525-27531, 2003 | | 2003 |
| KDO 8-P and DAH 7-P synthase: Potential therapeutic targets. RW Woodard, MR Birck, HS Duewel, DL Howe, GY Sheflyan, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 222, U161-U161, 2001 | | 2001 |
| Investigation of the Active Sites of 1-aminocyclopropane-1-carboxylic Acid Oxidase and the Pep-utilizing Enzymes 3-deoxy-D-arabino-heptulosonate 7-phosphate and 3-deoxy-D-manno … DL Howe University of Michigan, 2001 | | 2001 |
| Mechanistic comparisons of KDO 8-P synthase and DAH 7-P synthase. RW Woodard, WP Taylor, AK Sundaram, GY Sheflyan, DL Howe, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 219, U132-U133, 2000 | | 2000 |
| ENZYME CATALYSIS AND REGULATION-Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic … DL Howe, HS Duewel, RW Woodard Journal of Biological Chemistry 275 (51), 40258-40265, 2000 | | 2000 |
| Structure, Properties, and Thermal Stability of Nanocrystallite Fe–Ti–N Soft Magnetic Films.......................................... D. Li, Y.-S. Gu, X.-R. Chang, F.-S. Li, L … S Li, H Hofmann, PL Sergeant, LR Dupré, M De Wulf, JAA Melkebeek, ... | | |
