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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
E Giampazolias, B Zunino, S Dhayade, F Bock, C Cloix, K Cao, A Roca, ...
Nature cell biology 19 (9), 1116-1129, 2017
2192017
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
L Fort, JM Batista, PA Thomason, HJ Spence, JA Whitelaw, L Tweedy, ...
Nature cell biology 20 (10), 1159-1171, 2018
702018
NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation
M Nivon, L Fort, P Muller, E Richet, S Simon, B Guey, M Fournier, ...
Molecular biology of the cell 27 (11), 1712-1727, 2016
492016
Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility
X Zhang, G Lavoie, L Fort, EL Huttlin, J Tcherkezian, JA Galan, H Gu, ...
Molecular and cellular biology, 2013
442013
N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis
A Juin, HJ Spence, KJ Martin, E McGhee, M Neilson, MFA Cutiongco, ...
Developmental cell 51 (4), 431-445. e7, 2019
412019
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation
AH Le, T Yelland, NR Paul, L Fort, S Nikolaou, S Ismail, LM Machesky
Journal of Cell Biology 220 (9), e202012114, 2021
212021
Loss of N‐WASP drives early progression in an Apc model of intestinal tumourigenesis
HT Morris, L Fort, HJ Spence, R Patel, DF Vincent, JH Park, SB Snapper, ...
The Journal of Pathology 245 (3), 337-348, 2018
202018
Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells
L Fort, V Gama, IG Macara
Nature cell biology 24 (4), 434-447, 2022
112022
CYRI/Fam49 proteins represent a new class of Rac1 interactors
JA Whitelaw, S Lilla, NR Paul, L Fort, S Zanivan, LM Machesky
Communicative & Integrative Biology 12 (1), 112-118, 2019
92019
Apoptotic Find-me Signals are an Essential Driver of Stem Cell Conversion To The Cardiac Lineage
L Fort, V Gama, IG Macara
bioRxiv, 2021.06. 21.449262, 2021
32021
Chemotaxis in Pacreatic Ductal Adenocarcinoma Metastasis: An Unexpected Role of NWASP in Maintaining Self-Generated Gradients and LPA Receptor Recycling
A Juin, HJ Spence, KJ Martin, E McGhee, M Neilson, MFA Cutiongco, ...
22018
CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
S Nikolaou, A Juin, JA Whitelaw, NR Paul, L Fort, C Nixon, HJ Spence, ...
Elife 13, e83712, 2024
2024
CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
JA Whitelaw, S Lilla, S Nikolaou, L Tweedy, L Fort, NR Paul, S Zanivan, ...
bioRxiv, 2024.03. 26.586838, 2024
2024
Pathway to Independence: the future of developmental biology
P Agarwal, C Cadart, L Fort, J Gahan, L Greenspan, T Juan, P Kameneva, ...
Development 150 (19), 2023
2023
Messenger functions of cell death during development and homeostasis
L Fort
Biochemical Society Transactions 51 (2), 759-769, 2023
2023
Effect of N-Wasp knockout on tumour burden and survival in murine models of intestinal tumorigenesis and its potential as a prognostic biomarker in human colorectal cancer
HT Morris, L Fort, RA Ridgway, OJ Sansom, FA Carey, LM Machesky
The Lancet 389, S71, 2017
2017
CYRIPS (Fam49) proteins are local inhibitors of Rac1 and Scar/WAVE induced lamellipodia.
L Fort, J Batista, P Thomason, H Spence, J Greaves, K Martin, K Anderson, ...
Molecular Biology Of The Cell 28, 2017
2017
FAM49B: first negative regulator of the Scar/WAVE complex. From evolution to an in vivo analysis
L Fort
University of Glasgow, 2017
2017
A Highlights from MBoC Selection: NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation
M Nivon, L Fort, P Muller, E Richet, S Simon, B Guey, M Fournier, ...
Molecular Biology of the Cell 27 (11), 1712, 2016
2016
The Effect of N-WASP Knockout in Murine Models of Intestinal Tumourigenesis
HT Morris, L Fort, RA Ridgway, OJ Sansom, FA Carey, LM Machesky
JOURNAL OF PATHOLOGY 238, S9-S9, 2016
2016
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