| Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents ME Caputto, LE Fabian, D Benítez, A Merlino, N Ríos, H Cerecetto, ... Bioorganic & medicinal chemistry 19 (22), 6818-6826, 2011 | 86 | 2011 |
| 3-Trifluoromethylquinoxaline N,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Agents and Mechanism of Action Studies D Benitez, M Cabrera, P Hernández, L Boiani, ML Lavaggi, R Di Maio, ... Journal of medicinal chemistry 54 (10), 3624-3636, 2011 | 84 | 2011 |
| Risedronate metal complexes potentially active against Chagas disease B Demoro, F Caruso, M Rossi, D Benítez, M Gonzalez, H Cerecetto, ... Journal of inorganic biochemistry 104 (12), 1252-1258, 2010 | 83 | 2010 |
| Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-N-oxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs S Ancizu, E Moreno, E Torres, A Burguete, S Pérez-Silanes, D Benítez, ... Molecules 14 (6), 2256-2272, 2009 | 72 | 2009 |
| 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene A Gerpe, G Álvarez, D Benítez, L Boiani, M Quiroga, P Hernández, ... Bioorganic & medicinal chemistry 17 (21), 7500-7509, 2009 | 70 | 2009 |
| Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids D Benítez, A Medeiros, L Fiestas, EA Panozzo-Zenere, F Maiwald, ... PLoS neglected tropical diseases 10 (4), e0004617, 2016 | 67 | 2016 |
| Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma CS Graebin, MF Madeira, JKU Yokoyama-Yasunaka, DC Miguel, ... European journal of medicinal chemistry 45 (4), 1524-1528, 2010 | 59 | 2010 |
| Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum AF Sousa, AG Gomes-Alves, D Benítez, MA Comini, L Flohé, T Jaeger, ... Free Radical Biology and Medicine 73, 229-238, 2014 | 57 | 2014 |
| Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies D Castro, L Boiani, D Benitez, P Hernandez, A Merlino, C Gil, C Olea-Azar, ... European journal of medicinal chemistry 44 (12), 5055-5065, 2009 | 53 | 2009 |
| Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning LN Alberca, ML Sbaraglini, D Balcazar, L Fraccaroli, C Carrillo, ... Journal of computer-aided molecular design 30, 305-321, 2016 | 50 | 2016 |
| Development of second generation amidinohydrazones, thio-and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1, 3-dioxide core scaffolds A Merlino, D Benitez, S Chavez, J Da Cunha, P Hernández, LW Tinoco, ... Medchemcomm 1 (3), 216-228, 2010 | 50 | 2010 |
| Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase B Demoro, F Caruso, M Rossi, D Benítez, M González, H Cerecetto, ... Dalton Transactions 41 (21), 6468-6476, 2012 | 48 | 2012 |
| Synthesis of 2‐Hydrazolyl‐4‐Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi C Pizzo, C Saiz, A Talevi, L Gavernet, P Palestro, C Bellera, LB Blanch, ... Chemical biology & drug design 77 (3), 166-172, 2011 | 48 | 2011 |
| 2-Acetylpyridine-and 2-benzoylpyridine-derived thiosemicarbazones and their antimony (III) complexes exhibit high anti-trypanosomal activity GL Parrilha, RP Dias, WR Rocha, IC Mendes, D Benítez, J Varela, ... Polyhedron 31 (1), 614-621, 2012 | 40 | 2012 |
| Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides E Vicente, PR Duchowicz, D Benítez, EA Castro, H Cerecetto, M González, ... Bioorganic & medicinal chemistry letters 20 (16), 4831-4835, 2010 | 40 | 2010 |
| Coordination of nitro-thiosemicarbazones to ruthenium (II) as a strategy for anti-trypanosomal activity improvement C Rodrigues, AA Batista, J Ellena, EE Castellano, D Benítez, H Cerecetto, ... European journal of medicinal chemistry 45 (7), 2847-2853, 2010 | 39 | 2010 |
| 9-and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma F Maiwald, D Benítez, D Charquero, MA Dar, H Erdmann, L Preu, O Koch, ... European Journal of Medicinal Chemistry 83, 274-283, 2014 | 38 | 2014 |
| Amidines bearing benzofuroxan or benzimidazole 1, 3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain A Merlino, D Benitez, NE Campillo, JA Páez, LW Tinoco, M González, ... MedChemComm 3 (1), 90-101, 2012 | 28 | 2012 |
| Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage C Hiller, A Nissen, D Benítez, MA Comini, RL Krauth-Siegel PLoS Pathogens 10 (4), e1004075, 2014 | 27 | 2014 |
| Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd (II) and Pt (II) complexes of thiosemicarbazones derived from 1 … D Santos, B Parajón-Costa, M Rossi, F Caruso, D Benítez, J Varela, ... Journal of Inorganic Biochemistry 117, 270-276, 2012 | 27 | 2012 |
Marcelo CominiPrincipal Investigator, Institut Pasteur de Montevideo, UruguayVerified email at pasteur.edu.uy
