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Fredric Manfredsson
Fredric Manfredsson
Barrow Neurological Institute
Verified email at barrowneuro.org - Homepage
Title
Cited by
Cited by
Year
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
KL Paumier, KC Luk, FP Manfredsson, NM Kanaan, JW Lipton, TJ Collier, ...
Neurobiology of disease 82, 185-199, 2015
3902015
The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
OS Gorbatyuk, S Li, LF Sullivan, W Chen, G Kondrikova, FP Manfredsson, ...
Proceedings of the National Academy of Sciences 105 (2), 763-768, 2008
3692008
The contribution of alpha synuclein to neuronal survival and function–Implications for Parkinson's disease
MJ Benskey, RG Perez, FP Manfredsson
Journal of neurochemistry 137 (3), 331-359, 2016
2582016
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration
OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ...
Molecular Therapy 18 (8), 1450-1457, 2010
2332010
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
FP Manfredsson, KC Luk, MJ Benskey, A Gezer, J Garcia, NC Kuhn, ...
Neurobiology of disease 112, 106-118, 2018
1652018
Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders
RJ Mandel, FP Manfredsson, KD Foust, A Rising, S Reimsnider, K Nash, ...
Molecular Therapy 13 (3), 463-483, 2006
1592006
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
Z Zhang, SS Kang, X Liu, EH Ahn, Z Zhang, L He, PM Iuvone, DM Duong, ...
Nature structural & molecular biology 24 (8), 632-642, 2017
1582017
Deficiency in BDNF/TrkB neurotrophic activity stimulates δ-secretase by upregulating C/EBPβ in Alzheimer’s disease
ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsson, IM Sandoval, S Wu, ...
Cell reports 28 (3), 655-669. e5, 2019
1522019
Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat
S Reimsnider, FP Manfredsson, N Muzyczka, RJ Mandel
Molecular Therapy 15 (8), 1504-1511, 2007
1252007
A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures
TM Grabinski, A Kneynsberg, FP Manfredsson, NM Kanaan
PloS one 10 (3), e0120120, 2015
1232015
Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates
TJ Collier, DE Redmond, K Steece-Collier, JW Lipton, FP Manfredsson
Frontiers in neuroscience 10, 180553, 2016
1182016
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity
FP Manfredsson, N Tumer, B Erdos, T Landa, CS Broxson, LF Sullivan, ...
Molecular Therapy 17 (6), 980-991, 2009
1142009
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
ZH Wang, K Gong, X Liu, Z Zhang, X Sun, ZZ Wei, SP Yu, ...
Nature communications 9 (1), 1784, 2018
1082018
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease
SS Kang, Z Zhang, X Liu, FP Manfredsson, MJ Benskey, X Cao, J Xu, ...
Proceedings of the National Academy of Sciences 114 (40), 10773-10778, 2017
1052017
Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?
NM Kanaan, FP Manfredsson
Journal of Parkinson's disease 2 (4), 249-267, 2012
1002012
AAV9: a potential blood-brain barrier buster
FP Manfredsson, AC Rising, RJ Mandel
Molecular Therapy 17 (3), 403-405, 2009
972009
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system
SE Gombash, FP Manfredsson, CJ Kemp, NC Kuhn, SM Fleming, ...
PloS one 8 (11), e81426, 2013
952013
Silencing alpha synuclein in mature nigral neurons results in rapid neuroinflammation and subsequent toxicity
MJ Benskey, RC Sellnow, IM Sandoval, CE Sortwell, JW Lipton, ...
Frontiers in molecular neuroscience 11, 36, 2018
922018
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis
A Sturchio, AK Dwivedi, CB Young, T Malm, L Marsili, JS Sharma, ...
EClinicalMedicine 38, 2021
842021
α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease
SS Kang, EH Ahn, Z Zhang, X Liu, FP Manfredsson, IM Sandoval, ...
The EMBO journal 37 (12), e98878, 2018
822018
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