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Lukasz Bugaj
Lukasz Bugaj
Assistant Professor of Bioengineering, University of Pennsylvania
Verified email at seas.upenn.edu - Homepage
Title
Cited by
Cited by
Year
Optogenetic protein clustering and signaling activation in mammalian cells
LJ Bugaj, AT Choksi, CK Mesuda, RS Kane, DV Schaffer
Nature methods 10 (3), 249-252, 2013
3912013
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
JH Kim, LJ Bugaj, YJ Oh, TJ Bivalacqua, S Ryoo, KG Soucy, L Santhanam, ...
Journal of applied physiology 107 (4), 1249-1257, 2009
2692009
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ...
Science 361 (6405), eaao3048, 2018
1062018
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
H Yousef, MJ Conboy, A Morgenthaler, C Schlesinger, L Bugaj, P Paliwal, ...
Oncotarget 6 (14), 11959, 2015
1062015
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering
LJ Bugaj, DP Spelke, CK Mesuda, M Varedi, RS Kane, DV Schaffer
Nature communications 6 (1), 1-10, 2015
922015
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
J Steppan, S Ryoo, KH Schuleri, C Gregg, RK Hasan, AR White, LJ Bugaj, ...
Proceedings of the National Academy of Sciences 103 (12), 4759-4764, 2006
922006
Age-associated increase in BMP signaling inhibits hippocampal neurogenesis
H Yousef, A Morgenthaler, C Schlesinger, L Bugaj, IM Conboy, ...
Stem cells 33 (5), 1577-1588, 2015
832015
Modular engineering of cellular signaling proteins and networks
RM Gordley, LJ Bugaj, WA Lim
Current opinion in structural biology 39, 106-114, 2016
642016
High-throughput multicolor optogenetics in microwell plates
LJ Bugaj, WA Lim
Nature protocols 14 (7), 2205-2228, 2019
502019
Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics
SY Chen, LC Osimiri, M Chevalier, LJ Bugaj, TH Nguyen, RA Greenstein, ...
Cell systems 11 (4), 336-353. e24, 2020
382020
Interrogating cellular perception and decision making with optogenetic tools
LJ Bugaj, GP O’Donoghue, WA Lim
The Journal of cell biology 216 (1), 25, 2017
362017
Light-inducible activation of target mRNA translation in mammalian cells
J Cao, M Arha, C Sudrik, LJ Bugaj, DV Schaffer, RS Kane
Chemical Communications 49 (75), 8338-8340, 2013
362013
Vertebrate cells differentially interpret ciliary and extraciliary cAMP
ME Truong, S Bilekova, SP Choksi, W Li, LJ Bugaj, K Xu, JF Reiter
Cell 184 (11), 2911-2926. e18, 2021
332021
Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation
EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, BY Chow
Photochemical & Photobiological Sciences 19 (3), 353-361, 2020
192020
T cells selectively filter oscillatory signals on the minutes timescale
GP O’Donoghue, LJ Bugaj, W Anderson, KG Daniels, DJ Rawlings, ...
Proceedings of the National Academy of Sciences 118 (9), e2019285118, 2021
182021
Bringing next-generation therapeutics to the clinic through synthetic biology
LJ Bugaj, DV Schaffer
Current opinion in chemical biology 16 (3-4), 355-361, 2012
182012
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway
AR White, S Ryoo, L Bugaj, DO Attarzadeh, S Thiyagarajan, K Chen, ...
European journal of applied physiology 110 (2), 395-404, 2010
162010
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
M Khan, J Steppan, K Schuleri, S Ryoo, E Tuday, L Bugaj, L Santhanam, ...
European journal of applied physiology 112 (8), 2933-2941, 2012
142012
Single‐component optogenetic tools for inducible RhoA GTPase signaling
EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, JD Boerckel, BY Chow
Advanced Biology 5 (9), 2100810, 2021
122021
β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells
AB Rosenbloom, M Tarczyński, N Lam, RS Kane, LJ Bugaj, DV Schaffer
Proceedings of the National Academy of Sciences 117 (46), 28828-28837, 2020
112020
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Articles 1–20