Lukasz Bugaj
Lukasz Bugaj
Assistant Professor of Bioengineering, University of Pennsylvania
Verified email at - Homepage
Cited by
Cited by
Optogenetic protein clustering and signaling activation in mammalian cells
LJ Bugaj, AT Choksi, CK Mesuda, RS Kane, DV Schaffer
Nature methods 10 (3), 249-252, 2013
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
JH Kim, LJ Bugaj, YJ Oh, TJ Bivalacqua, S Ryoo, KG Soucy, L Santhanam, ...
Journal of applied physiology 107 (4), 1249-1257, 2009
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ...
Science 361 (6405), eaao3048, 2018
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
H Yousef, MJ Conboy, A Morgenthaler, C Schlesinger, L Bugaj, P Paliwal, ...
Oncotarget 6 (14), 11959, 2015
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering
LJ Bugaj, DP Spelke, CK Mesuda, M Varedi, RS Kane, DV Schaffer
Nature communications 6 (1), 1-10, 2015
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
J Steppan, S Ryoo, KH Schuleri, C Gregg, RK Hasan, AR White, LJ Bugaj, ...
Proceedings of the National Academy of Sciences 103 (12), 4759-4764, 2006
Age-associated increase in BMP signaling inhibits hippocampal neurogenesis
H Yousef, A Morgenthaler, C Schlesinger, L Bugaj, IM Conboy, ...
Stem cells 33 (5), 1577-1588, 2015
Modular engineering of cellular signaling proteins and networks
RM Gordley, LJ Bugaj, WA Lim
Current opinion in structural biology 39, 106-114, 2016
High-throughput multicolor optogenetics in microwell plates
LJ Bugaj, WA Lim
Nature protocols 14 (7), 2205-2228, 2019
Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics
SY Chen, LC Osimiri, M Chevalier, LJ Bugaj, TH Nguyen, RA Greenstein, ...
Cell systems 11 (4), 336-353. e24, 2020
Interrogating cellular perception and decision making with optogenetic tools
LJ Bugaj, GP O’Donoghue, WA Lim
The Journal of cell biology 216 (1), 25, 2017
Light-inducible activation of target mRNA translation in mammalian cells
J Cao, M Arha, C Sudrik, LJ Bugaj, DV Schaffer, RS Kane
Chemical Communications 49 (75), 8338-8340, 2013
Vertebrate cells differentially interpret ciliary and extraciliary cAMP
ME Truong, S Bilekova, SP Choksi, W Li, LJ Bugaj, K Xu, JF Reiter
Cell 184 (11), 2911-2926. e18, 2021
Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation
EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, BY Chow
Photochemical & Photobiological Sciences 19 (3), 353-361, 2020
T cells selectively filter oscillatory signals on the minutes timescale
GP O’Donoghue, LJ Bugaj, W Anderson, KG Daniels, DJ Rawlings, ...
Proceedings of the National Academy of Sciences 118 (9), e2019285118, 2021
Bringing next-generation therapeutics to the clinic through synthetic biology
LJ Bugaj, DV Schaffer
Current opinion in chemical biology 16 (3-4), 355-361, 2012
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway
AR White, S Ryoo, L Bugaj, DO Attarzadeh, S Thiyagarajan, K Chen, ...
European journal of applied physiology 110 (2), 395-404, 2010
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
M Khan, J Steppan, K Schuleri, S Ryoo, E Tuday, L Bugaj, L Santhanam, ...
European journal of applied physiology 112 (8), 2933-2941, 2012
Single‐component optogenetic tools for inducible RhoA GTPase signaling
EE Berlew, IA Kuznetsov, K Yamada, LJ Bugaj, JD Boerckel, BY Chow
Advanced Biology 5 (9), 2100810, 2021
β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells
AB Rosenbloom, M Tarczyński, N Lam, RS Kane, LJ Bugaj, DV Schaffer
Proceedings of the National Academy of Sciences 117 (46), 28828-28837, 2020
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