Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence JA Belk, W Yao, N Ly, KA Freitas, YT Chen, Q Shi, AM Valencia, E Shifrut, ... Cancer Cell 40 (7), 768-786. e7, 2022 | 132 | 2022 |
NOT-gated CD93 CAR T cells effectively target AML with minimized endothelial cross-reactivity RM Richards, F Zhao, KA Freitas, KR Parker, P Xu, A Fan, E Sotillo, ... Blood Cancer Discovery 2 (6), 648-665, 2021 | 50 | 2021 |
Enhanced T cell effector activity by targeting the Mediator kinase module KA Freitas, JA Belk, E Sotillo, PJ Quinn, MC Ramello, M Malipatlolla, ... Science 378 (6620), eabn5647, 2022 | 47 | 2022 |
Inosine induces stemness features in CAR-T cells and enhances potency DD Klysz, C Fowler, M Malipatlolla, L Stuani, KA Freitas, Y Chen, S Meier, ... Cancer Cell 42 (2), 266-282. e8, 2024 | 9 | 2024 |
Engineered CD47 protects T cells for enhanced antitumour immunity SA Yamada-Hunter, J Theruvath, BJ McIntosh, KA Freitas, F Lin, ... Nature, 1-9, 2024 | 3 | 2024 |
319 Transcriptome-guided design of logic-gated CAR T cells for treatment of acute myeloid leukemia T Woodring, KA Freitas, E Sotillo, CL Mackall, RM Richards Journal for ImmunoTherapy of Cancer 11 (Suppl 1), 2023 | | 2023 |
Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy SA Yamada-Hunter, J Theruvath, MT Radosevich, BJ McIntosh, ... Cancer Research 83 (7_Supplement), 5741-5741, 2023 | | 2023 |
THE KINASE MODULE OF THE MEDIATOR COMPLEX INHIBITS CAR T-CELL FUNCTION KA Freitas, JA Belk, E Sotillo, PJ Quinn, MC Ramello, M Malipatlolla CANCER DISCOVERY 13 (1), 9-13, 2023 | | 2023 |
Investigating Regulatory Mechanisms of T Cell Effector Function KA Freitas Stanford University, 2023 | | 2023 |
Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells KA Freitas, JA Belk, E Sotillo, B Daniel, K Sandor, D Klysz, VT Duong, ... bioRxiv, 2022.09. 02.506235, 2022 | | 2022 |
Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells KA Freitas, JA Belk, E Sotillo, B Daniel, K Sandor, D Klysz, VT Duong, ... Cancer Research 82 (12_Supplement), 2822-2822, 2022 | | 2022 |
Metabolic engineering of CAR-T cells overcomes suppressive adenosine signaling and enhances functionality D Klysz, M Malipatlolla, K Freitas, M Bashti, L Labanieh, P Xu, C Ramello, ... Cancer Research 82 (12_Supplement), 1362-1362, 2022 | | 2022 |